Prevention, Diagnosis and Treatment of Oral Mucosal Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 691

Special Issue Editor


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Guest Editor
Department of Oral Surgery & Dentistry, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
Interests: oral health; oral health care; oral cancer; oral infectious diseases; oral and maxillofacial surgery
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Special Issue Information

Dear Colleagues,

Oral mucosal diseases are closely related to oral and systemic health and are of increasing importance in medical practice, including cancer treatment. This Special Issue provides the latest findings on the prevention, diagnosis and treatment of a diverse range of conditions, including infections of the oral mucosa, precancerous lesions, oral mucositis and oral cancer. Through research papers and review articles by experts in their fields, the early detection, diagnosis, treatment and effective management of oral mucosal lesions are explored. It also focuses on the importance of oral care in patients with cancer and other diseases and the challenges faced in clinical practice and provides practical guidelines for oral mucosal management.

Dr. Masanobu Abe
Guest Editor

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Keywords

  • oral mucosal diseases
  • oral mucositis
  • oral precancerous lesions
  • oral cancer
  • oral potentially malignant disorders
  • OPMDs
  • oral leukoplakia

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Published Papers (1 paper)

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Research

11 pages, 6059 KiB  
Article
Healing with Love: Oxytocin Accelerates Oral Ulcer Recovery by Reducing Inflammation
by Mert Zeytinoğlu, Osman Sezer Çınaroğlu, Ejder Saylav Bora and Oytun Erbaş
J. Clin. Med. 2025, 14(8), 2667; https://doi.org/10.3390/jcm14082667 - 14 Apr 2025
Viewed by 473
Abstract
Background: Oral ulcerative mucositis (OUM) is a painful, inflammatory mucosa lesion that impairs quality of life. Despite available treatments, effective agents that promote faster healing and modulate inflammation are still needed. Oxytocin (OT), a neuropeptide with anti-inflammatory and antioxidant properties, may aid wound [...] Read more.
Background: Oral ulcerative mucositis (OUM) is a painful, inflammatory mucosa lesion that impairs quality of life. Despite available treatments, effective agents that promote faster healing and modulate inflammation are still needed. Oxytocin (OT), a neuropeptide with anti-inflammatory and antioxidant properties, may aid wound healing by regulating the remodeling of the extracellular matrix (ECM). This study investigates the effects of OT on oral ulcer healing in rats, focusing on its modulation of the MMP-2/TIMP-2 pathway. Methods: Acetic acid 70% was used as the oral mucosal ulcer inducer. Thirty-six Wistar albino rats were divided into control, oral ulcer + saline, and oral ulcer + OT (intraperitoneally for 15 days) groups. Histopathological, biochemical, and molecular analyses were performed. Buccal mucosa tissue was examined for TNF-α, TIMP-2, and MMP-2 levels via ELISA, while oxidative stress markers and pentraxin-3 (PTX3) were also assessed. Results: OT significantly preserved epithelial integrity and reduced fibrosis compared to the saline group (p < 0.001). TNF-α, MMP-2, PTX3, and malondialdehyde levels were significantly lower, while TIMP-2 levels were elevated in the OT-treated group (p < 0.01). Histopathological analysis confirmed reduced inflammation and enhanced tissue organization. Conclusions: OT accelerates oral ulcer healing by modulating inflammation, oxidative stress, and ECM remodeling via the MMP-2/TIMP-2 pathway. These findings highlight its potential as a therapeutic agent for managing mucosal injuries. Further clinical studies are warranted. Full article
(This article belongs to the Special Issue Prevention, Diagnosis and Treatment of Oral Mucosal Diseases)
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