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Prevention, Diagnosis and Treatment of Oral Mucosal Diseases
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Prevention, Diagnosis and Treatment of Oral Mucosal Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1500

Special Issue Editor

Dr. Masanobu Abe

E-Mail Website
Guest Editor
Department of Oral Surgery & Dentistry, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
Interests: oral health; oral health care; oral cancer; oral infectious diseases; oral and maxillofacial surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral mucosal diseases are closely related to oral and systemic health and are of increasing importance in medical practice, including cancer treatment. This Special Issue provides the latest findings on the prevention, diagnosis and treatment of a diverse range of conditions, including infections of the oral mucosa, precancerous lesions, oral mucositis and oral cancer. Through research papers and review articles by experts in their fields, the early detection, diagnosis, treatment and effective management of oral mucosal lesions are explored. It also focuses on the importance of oral care in patients with cancer and other diseases and the challenges faced in clinical practice and provides practical guidelines for oral mucosal management.

Dr. Masanobu Abe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral mucosal diseases
  • oral mucositis
  • oral precancerous lesions
  • oral cancer
  • oral potentially malignant disorders
  • OPMDs
  • oral leukoplakia

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Published Papers (2 papers)

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Research

14 pages, 259 KiB  
Article
Effects of Comorbid Disease Improvement on Oral Lichen Planus (OLP) and Oral Leukoplakia (OL) Lesions: A Retrospective Longitudinal Study
by Ildikó Tar, Szarka Krisztina, Renáta Martos, Csongor Kiss and Ildikó Márton
J. Clin. Med. 2025, 14(10), 3408; https://doi.org/10.3390/jcm14103408 - 13 May 2025
Viewed by 649
Abstract
Background: Previous attempts to treat oral potentially malignant disorders OPMDs) effectively have failed. Longitudinal studies investigating the effects of comorbid diseases improvement on OPMDs are not yet available. Therefore, the current study examined the effects of comorbid disease improvement on OPMDs healing, both [...] Read more.
Background: Previous attempts to treat oral potentially malignant disorders OPMDs) effectively have failed. Longitudinal studies investigating the effects of comorbid diseases improvement on OPMDs are not yet available. Therefore, the current study examined the effects of comorbid disease improvement on OPMDs healing, both in oral lichen planus (OLP) and oral leukoplakia (OL) patients. Methods: The data from 197 consecutive patients (144 females and 53 males, age ± SD: 55.19 ± 12.37 years, with ages ranging from 23 to 91 years), with oral lesions considered OLP and OL, were processed and evaluated. The frequency of comorbid diseases and the presence of HPV (here, subtypes were not evaluated) in the lesions in OLP and OL patient groups were evaluated and compared to the results of controls (n = 139). Risk models for OLP and OL lesions were established. High-risk models for erosive–atrophic OLP and non-homogeneous OLP were also described. The influence of comorbid disease improvement was also evaluated. Lesions were scored at the first and last visit (full recovery = 0, improvement = 1, and no improvement = 2). Results: One hundred and ninety-seven patients (144 OLP + 53 OL) were followed up for an average of 47.66 months (min–max: 1–203 months, SD: 54.19). Based on the established models, HPV infection, iron deficiency, diabetes, and thyroid function disorders seem to act as risk factors for OLP and may also affect OL formation. The improvement in comorbid diseases can cause significant improvement in OLP and OL lesions. Conclusions: By meticulous follow-up of comorbid diseases, improvement in OLP and OL lesions can be achieved. Full article
(This article belongs to the Special Issue Prevention, Diagnosis and Treatment of Oral Mucosal Diseases)
11 pages, 6059 KiB  
Article
Healing with Love: Oxytocin Accelerates Oral Ulcer Recovery by Reducing Inflammation
by Mert Zeytinoğlu, Osman Sezer Çınaroğlu, Ejder Saylav Bora and Oytun Erbaş
J. Clin. Med. 2025, 14(8), 2667; https://doi.org/10.3390/jcm14082667 - 14 Apr 2025
Viewed by 579
Abstract
Background: Oral ulcerative mucositis (OUM) is a painful, inflammatory mucosa lesion that impairs quality of life. Despite available treatments, effective agents that promote faster healing and modulate inflammation are still needed. Oxytocin (OT), a neuropeptide with anti-inflammatory and antioxidant properties, may aid wound [...] Read more.
Background: Oral ulcerative mucositis (OUM) is a painful, inflammatory mucosa lesion that impairs quality of life. Despite available treatments, effective agents that promote faster healing and modulate inflammation are still needed. Oxytocin (OT), a neuropeptide with anti-inflammatory and antioxidant properties, may aid wound healing by regulating the remodeling of the extracellular matrix (ECM). This study investigates the effects of OT on oral ulcer healing in rats, focusing on its modulation of the MMP-2/TIMP-2 pathway. Methods: Acetic acid 70% was used as the oral mucosal ulcer inducer. Thirty-six Wistar albino rats were divided into control, oral ulcer + saline, and oral ulcer + OT (intraperitoneally for 15 days) groups. Histopathological, biochemical, and molecular analyses were performed. Buccal mucosa tissue was examined for TNF-α, TIMP-2, and MMP-2 levels via ELISA, while oxidative stress markers and pentraxin-3 (PTX3) were also assessed. Results: OT significantly preserved epithelial integrity and reduced fibrosis compared to the saline group (p < 0.001). TNF-α, MMP-2, PTX3, and malondialdehyde levels were significantly lower, while TIMP-2 levels were elevated in the OT-treated group (p < 0.01). Histopathological analysis confirmed reduced inflammation and enhanced tissue organization. Conclusions: OT accelerates oral ulcer healing by modulating inflammation, oxidative stress, and ECM remodeling via the MMP-2/TIMP-2 pathway. These findings highlight its potential as a therapeutic agent for managing mucosal injuries. Further clinical studies are warranted. Full article
(This article belongs to the Special Issue Prevention, Diagnosis and Treatment of Oral Mucosal Diseases)
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