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Clinical Advances in Treatment for Venous Thromboembolism

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 25 January 2026 | Viewed by 1867

Special Issue Editors


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Guest Editor
Department of Transfusion Service and Clinical Hemostasis, Saint Savas Cancer Hospital, 11522 Athens, Greece
Interests: venous thromboembolism; thrombophilia; anticoagulation; hospital-acquired condition; cancer-associated thrombosis; pregnancy and thrombophilia

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Guest Editor
1st Medical Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: thrombosis; bleeding; thrombosis in MPN; thrombophilia; anticoagulation

Special Issue Information

Dear Colleagues,

Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and potentially fatal disease. The management strategies for VTE have changed dramatically over the past decade, and these changes include the introduction of direct oral anticoagulants (DOACs) for thromboprophylaxis and other treatments. A key concern in treating VTE is determining the optimal duration of anticoagulation in order to prevent its recurrence. According to recent evidence, this should be tailored to each patient by weighing up the risk of a recurrence of VTE and the risk of bleeding. Although there have been significant advances in VTE management, several uncertainties continue to challenge clinicians in everyday practice, such as VTE associated with cancer, VTE in unusual-sites, antiphospholipid syndrome, and minor cases, such as subsegmental pulmonary embolism and distal deep vein thrombosis. These areas require further research, and several clinical trials are currently underway to address them. While DOACs have quickly supplanted VKAs and have led to a significant rise in the global use of anticoagulant medications due to their effectiveness, safety, and ease of use, the risk of bleeding remains a concern, as is the case with all anticoagulant treatments. In response to this unmet clinical need, research has begun to focus on novel targets within the coagulation cascade. This Special Issue will be devoted to these topics, and we invite all interested authors to submit papers on “Clinical Advances in Treatment for Venous Thromboembolism”.

Dr. Elisavet Grouzi
Dr. Georgia Kaiafa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • venous thromboembolism
  • anticoagulation
  • cancer-associated thrombosis
  • thrombosis in MPNs
  • thrombosis in multiple myeloma
  • antiphospholipidic syndrome
  • thrombosis in PNH
  • thrombosis in hemoglobinopathies
  • thrombophilia
  • pregnancy and thrombophilia
  • reversal of anticoagulants
  • thromboprophylaxis

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Published Papers (2 papers)

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Editorial

Jump to: Review

7 pages, 194 KB  
Editorial
Psychological Stress and Venous Thromboembolism: A Narrative Overview
by Mathias Chea, Chloé Bourguignon, Antonia Perez-Martin and Jean-Christophe Gris
J. Clin. Med. 2025, 14(15), 5562; https://doi.org/10.3390/jcm14155562 - 7 Aug 2025
Viewed by 511
Abstract
“There is a tendency among young men about hospitals to study the cases, not the patients and, in the interest they take in the disease, lose sight of the individual [...] Full article
(This article belongs to the Special Issue Clinical Advances in Treatment for Venous Thromboembolism)

Review

Jump to: Editorial

21 pages, 1371 KB  
Review
Activated Complement System’s Impact in Antiphospholipid Syndrome Thrombosis: From Pathophysiology to Treatment
by Sofia Tagara, Serena Valsami, Eleni Gavriilaki, Elias Kyriakou, Elisavet Grouzi, Paschalis Evangelidis, Paraskevi Karvouni, Georgia Kaiafa, Ioannis Papadakis, Aristarchos Poulis, Eleni Petrou, Marianna Politou and Styliani Kokoris
J. Clin. Med. 2025, 14(18), 6672; https://doi.org/10.3390/jcm14186672 - 22 Sep 2025
Viewed by 1019
Abstract
Antiphospholipid syndrome (APS) is the most common acquired form of thrombophilia and is associated with the presence of antiphospholipid antibodies (aPL) in the patient’s serum. Until now, the “double-hit” hypothesis remains the prevailing theory for APS pathogenesis. According to this model, the presence [...] Read more.
Antiphospholipid syndrome (APS) is the most common acquired form of thrombophilia and is associated with the presence of antiphospholipid antibodies (aPL) in the patient’s serum. Until now, the “double-hit” hypothesis remains the prevailing theory for APS pathogenesis. According to this model, the presence of aPL (first hit) is insufficient to trigger thrombosis. A secondary event, such as an inflammatory trigger or vascular injury (second hit), is required to initiate immunothrombosis, which ultimately leads to thromboembolism. Although immunothrombosis has a critical role in several mechanisms, such as in defense against pathogens, chronic immune system activation by aPL appears to disrupt its protective function. In the last three decades, the role of the complement system has gained increasing recognition in the pathophysiology of APS. aPL are involved in the dysregulation of multiple components, such as platelets, β2-glycoprotein I, and complement factor H, resulting in excessive activation of the complement system. Thus, the complement system is a key driver of thrombosis in APS and stands as a promising target for the development of future therapeutic strategies. In the current review article, we aim to summarize the ongoing research regarding the role of complement system dysregulation in APS-associated thrombosis development, while recognizing potential therapeutic targets. In the era of precision medicine, more data concerning targeted therapeutics in the field of APS are essential. Full article
(This article belongs to the Special Issue Clinical Advances in Treatment for Venous Thromboembolism)
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