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Advances in Clinical Practice and Personalized Approaches in Cardiovascular Disease—2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 326

Editors


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Guest Editor
Department of Cardiovascular Medicine, Flinders Medical Centre, Adelaide, SA 5042, Australia
Interests: heart failure; cardiomyopathies; cardiac magnetic resonance imaging; coronary artery disease; arrhythmia disorders
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5000, Australia
Interests: myocardial infarction with non-obstructive coronary arteries (MINOCA); angina with non-obstructive coronary arteries (ANOCA); cardiac magnetic resonance imaging; coronary artery disease; heart failure; cardiomyopathies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce this Special Issue, “Advances in Clinical Practice and Personalized Approaches in Cardiovascular Disease—2nd Edition”, which we are launching as a result of the success of the first edition, in which we published 10 papers. For more details, please visit https://www.mdpi.com/journal/jcm/special_issues/3IV66I28J9.

This Special Issue will address emerging challenges and innovations in the management of cardiovascular disease, with a focus on advancing clinical practice through personalized approaches. As cardiovascular disease remains a leading cause of mortality worldwide, there is an urgent need for tailored interventions that account for individual patient variability. Recent advances in imaging technologies and data-driven predictive models have opened up new pathways in precision medicine. However, the translation of these innovations into clinical practice involves hurdles such as heterogeneous patient populations and the integration of multimodal data.

For this Special Issue, we invite original research articles and reviews that explore personalized diagnostics, therapeutic strategies, and preventive measures in cardiovascular care. The scope includes novel biomarkers, cutting-edge imaging techniques, patient stratification methods, and advancements in pharmacotherapy to enhance treatment plans. The goal is to bring together leading experts in this field to share knowledge and promote future efforts to bridge the gap between research and clinical application, ultimately improving patient outcomes.

Prof. Dr. Joseph B. Selvanayagam
Dr. Sivabaskari Pasupathy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized medicine
  • cardiovascular innovations
  • cardiac imaging
  • risk assessment
  • multimodal imaging
  • therapeutic strategies
  • data-driven decision making
  • clinical outcomes
  • translational research

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Published Papers (1 paper)

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Research

21 pages, 2435 KB  
Article
Comparative Analysis of the Association of Biomarkers of Endothelial Dysfunction and Systemic Inflammation in Patients with Coronary Artery Disease with the Presence/Absence of Personality Type D
by Alexey N. Sumin, Natalia N. Zagorskaya, Natalia A. Bezdenezhnykh, Anna V. Shcheglova, Yaroslav I. Bryukhanov and Anna V. Sinitskaya
J. Clin. Med. 2026, 15(13), 5227; https://doi.org/10.3390/jcm15135227 - 3 Jul 2026
Abstract
Background: The aim of this study was to comprehensively analyze the relationships within a multimodal biomarker panel, including endothelial function indicators, markers of systemic inflammation and myocardial stress, metabolic homeostasis parameters, and an indicator of microstructural damage to nerve tissue in CAD [...] Read more.
Background: The aim of this study was to comprehensively analyze the relationships within a multimodal biomarker panel, including endothelial function indicators, markers of systemic inflammation and myocardial stress, metabolic homeostasis parameters, and an indicator of microstructural damage to nerve tissue in CAD patients with or without type D personality. Methods: This exploratory, cross-sectional, observational study included 72 patients with coronary artery disease. All patients underwent psychological testing (evaluation of type D personality and determination of depression and anxiety levels) and biomarker measurements. The multimodal biomarker panel included measurements of metabolic homeostasis parameters (glucose, total cholesterol, creatinine, insulin, 1,5-anhydroglucitol), markers of systemic inflammation (CRP, IL-6), myocardial stress (NTproBNP), endothelial function parameters (eNOS, EDN1, ADMA, VEGF), and an indicator of microstructural damage to nerve tissue (S100B protein). Results: Biomarker levels revealed no statistically significant differences between the groups with and without personality type D. In personality type D, a direct correlation was found between the level of the brain tissue damage marker S100B and eNOS concentration (R = 0.578; p = 0.006), which was not observed in non-type D. In patients with personality type D, a significant inverse correlation was confirmed between ADMA and creatinine levels (R = −0.524; p = 0.015). In individuals with non-type D personality, a direct correlation was established between total cholesterol levels and VEGF (R = 0.342; p = 0.014). Conclusions: In patients with coronary heart disease, psychological distress (type D) is associated not with an isolated change in biomarker concentrations but with a transformation of the entire structure of their relationships. Personality type D is characterized by a transition from the physiological autonomy of systems to the formation of pathogenetic relationships between them, indicating a decrease in adaptive reserve. Full article
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