Corneal Diseases: Clinical Perspectives from Diagnosis to Treatment

Dear Colleagues,

Corneal diseases, encompassing a broad spectrum of conditions that affect the transparency, biomechanics, and endothelial function of the cornea, remain a leading cause of visual impairment worldwide. Continuous advances in diagnostics, imaging, and surgical techniques are rapidly transforming how these disorders are identified and managed. This Special Issue aims to provide a focused and clinically relevant overview of current and emerging concepts in corneal disease, with particular emphasis on the link between accurate diagnosis and optimal therapeutic decision-making.

We welcome original research articles, reviews, meta-analyses, and high-quality clinical studies addressing both common and complex corneal conditions. Topics of particular interest include keratoconus and other ectatic disorders, advances in corneal imaging and biomechanics, disease staging, progression risk stratification, and treatment strategies such as corneal cross-linking, intracorneal ring segments, and keratoplasty.

Submissions focusing on corneal transplantation are strongly encouraged, including studies on penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), and endothelial keratoplasty techniques such as Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). Relevant themes include indications, surgical refinements, donor–recipient factors, graft survival, endothelial cell loss, primary graft failure, rejection, long-term outcomes, and comparative analyses between techniques.

Additional areas of interest include infectious and inflammatory keratitis, corneal dystrophies and degenerations, endothelial disorders, ocular surface disease, postoperative and iatrogenic corneal complications, and novel medical, surgical, and regenerative therapies. Studies integrating advanced diagnostics—such as anterior segment OCT, corneal tomography, confocal microscopy, and emerging biomarkers—with clinical outcomes are particularly welcome.

By highlighting evidence-based advances from diagnosis to treatment, this Special Issue seeks to inform daily clinical decision-making and to outline future directions in the management of corneal disease.

Dr. Davide Romano
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cornea
• keratoplasty
• keratitis
• keratoconus
• clinical perspectives