Rewriting Metastatic Colorectal Cancer Management: Innovative Frontiers in Clinical Diagnosis and Personalized Oncology
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: 24 July 2026
Special Issue Editor
Interests: clinical oncology; cancer biology; cancer diagnostics; medical oncology; molecular oncology; tumor markers; cancer immunology; translational cancer research; gastrointestinal tumors
Special Issue Information
Dear Colleagues,
Metastatic colorectal cancer (mCRC) is entering a transformative era driven by precision diagnostics, molecular stratification, and novel therapeutic modalities. Despite significant advances, mCRC remains a major clinical challenge due to biological heterogeneity, limited treatment durability, and the need for more effective patient selection strategies. This Special Issue aims to highlight innovative frontiers that redefine mCRC management—from next-generation molecular profiling and liquid biopsy technologies to targeted therapies, immunotherapy combinations, and integrated multimodality approaches. Core problems to be addressed include resistance mechanisms, the optimization of treatment sequencing, the identification of actionable biomarkers, and the translation of real-world data into personalized care.
The scope of the Special Issue encompasses original research, clinical studies, and comprehensive reviews that advance precision diagnosis and individualized therapy. By mobilizing multidisciplinary expertise across oncology, pathology, molecular biology, surgery, computational sciences, and imaging, this collection seeks to accelerate the progress toward more effective, tailored, and durable treatments for patients with mCRC.
Dr. Maria Maddalena Laterza
Guest Editor
Manuscript Submission Information
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Keywords
- molecular profiling
- liquid biopsy
- targeted therapy
- immunotherapy
- biomarkers treatment
- sequencing
- tumor heterogeneity
- personalized medicine
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