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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oral Health and Dental Care: Current Advances and Future Options
edited by , and Alessia Bramanti
submission deadline 31 Dec 2025 | 1 articles | Viewed by 429 | Submission Open
Keywords: oral health; dental care; technologies; innovation; dental materials
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Evidence-Based Diagnosis and Clinical Management of Low Back Pain submission deadline 31 Dec 2025 | Viewed by 214 | Submission Open
Keywords: low back pain; classification systems; risk stratification; health services research; management strategies; timing and sequencing; prognosis; predictor; clinical decision making; primary care
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Updates on Prenatal Diagnosis
edited by Valentina D'Ambrosio
submission deadline 31 Dec 2025 | Viewed by 177 | Submission Open
Keywords: fetal anomalies; twin pregnancy; fetal therapy; prenatal genetic testing; genome sequencies
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction submission deadline 31 Dec 2025 | Viewed by 167 | Submission Open
Keywords: dry eye disease; ocular surface; corneal disease; conjunctival disease; ocular biomarkers; patient-centered care; advanced diagnostics; regenerative medicine; artificial intelligence; therapeutic innovations
(This special issue belongs to the Section Ophthalmology)
Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions
edited by Pietro C. Dattolo and
submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open
Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology
(This special issue belongs to the Section Nephrology & Urology)
Advances in Gene Therapy for Retinal Diseases
edited by Tahreem Aman Mir
submission deadline 31 Dec 2025 | Viewed by 116 | Submission Open
Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy
(This special issue belongs to the Section Ophthalmology)
Orthopedic Oncology Updates and Controversial Issues
edited by Yehuda Kollender and Ron Batash
submission deadline 31 Dec 2025 | Viewed by 109 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; oligometastatic; atypical behavior tumor; cryosurgery; rare diseases; surgery; radiation therapy; immunotherapy; chemotherapy
(This special issue belongs to the Section Orthopedics)
Recent Progress and Future Directions in Orthopedic Oncology
edited by and Carmine Zoccali
submission deadline 31 Dec 2025 | Viewed by 106 | Submission Open
Keywords: orthopedic oncology; bone tumors; limb-sparing surgery; reconstruction techniques; 3D-printed implants; navigation and robotics; precision medicine in musculoskeletal oncology
(This special issue belongs to the Section Orthopedics)
Clinical Trends in Diagnostic Radiology
edited by Wolfram Schwindt, Benjamin Noto and Anne Helfen
submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open
Keywords: diagnostic imaging; radiology; nuclear medicine; hybrid imaging; artificial intelligence; radiomics; quantitative imaging; theranostics; imaging biomarkers; clinical applications
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Pregnancy Complications and Maternal-Perinatal Outcomes
edited by
submission deadline 31 Dec 2025 | Viewed by 89 | Submission Open
Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound
(This special issue belongs to the Section Obstetrics & Gynecology)
Innovations in Psychosis and Schizophrenia: New Findings and Implications
edited by
submission deadline 31 Dec 2025 | Viewed by 87 | Submission Open
Keywords: schizophrenia; psychosis; psychopathology; neurobiology; assessment; pharmacological treatment; psychosocial interventions
(This special issue belongs to the Section Mental Health)
Advances in Clinical Approaches to Breast Cancer Diagnosis and Treatment
edited by
submission deadline 31 Dec 2025 | Viewed by 69 | Submission Open
Keywords: breast cancer; diagnosis; precision medicine; molecular profiling; targeted therapy; breast-conserving surgery; minimally invasive techniques; artificial intelligence; personalized medicine; radiation therapy
(This special issue belongs to the Section Oncology)
The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment submission deadline 31 Dec 2025 | Viewed by 66 | Submission Open
Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine
(This special issue belongs to the Section Cardiovascular Medicine)
Emerging Clinical Insights into Adolescent Behavioral Development and Mental Health
edited by and Anne-Marie Iselin
submission deadline 31 Dec 2025 | Viewed by 63 | Submission Open
Keywords: adolescence; behavioral development; clinical maladjustment; adolescents’ mental health; innovative clinical approach; adolescents’ emotional problems; clinical settings; innovative developmental research; adolescents’ symptoms
(This special issue belongs to the Section Mental Health)
Paradigms, Advances and Future Directions in Oral Medicine
edited by
submission deadline 31 Dec 2025 | Viewed by 57 | Submission Open
Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management
edited by Adam Gwozdz
submission deadline 31 Dec 2025 | Viewed by 53 | Submission Open
Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery
(This special issue belongs to the Section Vascular Medicine)
Progress in the Multimodal Treatment of Pancreatic Disease
edited by
submission deadline 31 Dec 2025 | Viewed by 53 | Submission Open
Keywords: pancreatic diseases; pancreatic cancer; multimodal treatment; neoadjuvant therapy; imaging techniques; minimally invasive surgery; immunotherapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment
edited by
submission deadline 5 Jan 2026 | 1 articles | Viewed by 955 | Submission Open
Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted
(This special issue belongs to the Section Mental Health)
Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition
edited by
submission deadline 9 Jan 2026 | 1 articles | Viewed by 721 | Submission Open
Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Advance in Chronic Total Occlusion Percutaneous Coronary Intervention
edited by Anbukarasi Maran and Kevin Croce
submission deadline 9 Jan 2026 | Viewed by 48 | Submission Open
Keywords: chronic total occlusion (CTO); percutaneous coronary intervention (PCI); innovative techniques; guidewire technology; retrograde PCI; interventional cardiology  
(This special issue belongs to the Section Cardiovascular Medicine)
New Clinical Advances in Pancreatobiliary Diseases
edited by
submission deadline 9 Jan 2026 | Viewed by 34 | Submission Open
Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Guidelines in Critical Care Medicine
edited by , and Daniela Bandic-Pavlovic
submission deadline 10 Jan 2026 | 3 articles | Viewed by 3041 | Submission Open
Keywords: critical illness; immunocompromised host; biomarkers; thrombocytopenia; blood coagulation disorders; multiple trauma; diagnostic imaging
(This special issue belongs to the Section Intensive Care)
Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities submission deadline 10 Jan 2026 | 1 articles | Viewed by 950 | Submission Open
Keywords: heart failure; acute myocardial infarction; coronary artery diseases; cardiac imaging; biomarkers; artificial intelligence
(This special issue belongs to the Section Cardiovascular Medicine)
From Acute Injury to Personalized Prevention—Developing Modern Strategies submission deadline 10 Jan 2026 | Viewed by 115 | Submission Open
Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention
(This special issue belongs to the Section Orthopedics)
Advanced Physiotherapy Practice in Patients with Musculoskeletal Disorders submission deadline 10 Jan 2026 | Viewed by 45 | Submission Open
Keywords: differential diagnosis; physiotherapy; rehabilitation; multidisciplinary; effectiveness; musculoskeletal disorders; screening for referral; manual therapy; exercise; cognitive behavioral therapy; pain neuroscience
(This special issue belongs to the Section Clinical Rehabilitation)
Pelvic Organ Prolapse: Clinical Advances and Challenges submission deadline 10 Jan 2026 | Viewed by 34 | Submission Open
Keywords: pelvic organ prolapse; pessary treatment; uterus-preserving prolapse surgery; clinical management; clinical treatment
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Vascular and Endovascular Surgery: Second Edition
edited by and Afshin Assadian
submission deadline 11 Jan 2026 | Viewed by 81 | Submission Open
Keywords: vascular surgery; endovascular surgery; aortic surgery; peripheral arterial disease; vascular imaging; EVAR; FEVAR; vascular access; vascular education; aneurysms
(This special issue belongs to the Section Vascular Medicine)
Physical Therapy in Neurorehabilitation submission deadline 15 Jan 2026 | 7 articles | Viewed by 11731 | Submission Open
Keywords: physical therapy; transcutaneous electrical nerve stimulation (TENS); muscle strengthening; balance exercising; pain; quality of life; neurodegenerative disorders; neuromuscular disorders; stroke; demyelinating disorders
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates in Physiotherapy for Musculoskeletal Disorders submission deadline 15 Jan 2026 | 7 articles | Viewed by 8629 | Submission Open
Keywords: musculoskeletal disorders; physiotherapy interventions; lifestyle; psychoneuroimmunology; chronic pain; inflammation; physical therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Safety in Spinal Surgery
edited by Simon B. Roberts and
submission deadline 15 Jan 2026 | 1 articles | Viewed by 1375 | Submission Open
Keywords: spinal surgery; patients with spinal deformity; inherent risks; risk management; surgery safety
(This special issue belongs to the Section General Surgery)
Current Trends and Prospects of Critical Emergency Medicine
edited by Quincy K. Tran
submission deadline 15 Jan 2026 | 3 articles | Viewed by 980 | Submission Open
Keywords: critically ill patients; critical care; resuscitation; emergency medicine; trends; prospects; outcomes
(This special issue belongs to the Section Emergency Medicine)
Diagnosis and Management of Aortic Diseases: Drafting from Theoretical Aspects to Clinical Practice—2nd Edition
edited by
submission deadline 15 Jan 2026 | 1 articles | Viewed by 828 | Submission Open
Keywords: aortic disease; aortic aneurysm; aortic dissection; aortic surgery; diagnosis and management
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in the Diagnosis and Treatment of Cardiac Arrhythmias
edited by Fabrizio Guarracini and
submission deadline 15 Jan 2026 | 1 articles | Viewed by 685 | Submission Open
Keywords: cardiac arrhythmias; antiarrhythmic agents; pacemakers; cardiac resynchronization; catheter ablation; electrophysiology
(This special issue belongs to the Section Cardiology)
Pediatric Nephrology: Advances in the Diagnosis and Management of Pediatric Kidney Disorders submission deadline 15 Jan 2026 | 1 articles | Viewed by 465 | Submission Open
Keywords: diagnosis; management; treatment; kidney disorders; chronic kidney disease; biomarkers; genetic testing; kidney; children; newborn
(This special issue belongs to the Section Nephrology & Urology)
Up-to-Date Research in Liver Transplantation
edited by
submission deadline 15 Jan 2026 | 1 articles | Viewed by 444 | Submission Open
Keywords: liver transplantation; acute or chronic liver diseases; hepatitis C virus infection; hepatocellular carcinoma (HCC); cirrhosis; intrahepatic (ICCA); perihilar (PCCA) cholangiocarcinoma; unresectable liver metastases; acute or chronic liver failure (ACLF); acute alcoholic hepatitis (AAH)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Pediatric Urology: How to Adapt Current Knowledge to the New Era
edited by Simona Gerocarni Nappo and
submission deadline 15 Jan 2026 | Viewed by 273 | Submission Open
Keywords: pediatric urology; telemedicine; telesurgery; artificial intelligence; 3D-models; congenital urinary diseases; pediatric oncology
(This special issue belongs to the Section Clinical Pediatrics)
Advances in Pulmonary Disease Management and Innovation in Treatment submission deadline 15 Jan 2026 | Viewed by 90 | Submission Open
Keywords: severe asthma; COPD; sleep-related breathing disorders; respiratory tract infections; innovative respiratory therapies; translational pulmonary research; pulmonary vascular disease; interstitial lung disease; eHealth in respiratory care
(This special issue belongs to the Section Respiratory Medicine)
Advances in Minimally Invasive Cardiothoracic Surgery: Current Techniques and Future Innovations submission deadline 15 Jan 2026 | Viewed by 58 | Submission Open
Keywords: cardiothoracic surgery; lung cancer; cardiac imaging; minimally invasive surgery; thoracic oncology
(This special issue belongs to the Section Cardiovascular Medicine)
Intracranial Hemorrhage: Advances in Diagnosis, Management and Treatment
edited by Hitoshi Fukuda
submission deadline 15 Jan 2026 | Viewed by 58 | Submission Open
Keywords: intracerebral hemorrhage; subarachnoid hemorrhage; traumatic hemorrhage; prehospital care; less invasive surgery; vascular malformation; antihypertensive drug; intracranial pressure elevation; decompressive craniectomy; neurocritical care; nursing care; rehabilitation
(This special issue belongs to the Section Clinical Neurology)
Recent Clinical Advances in Percutaneous Coronary Intervention
edited by and Luke Pickup
submission deadline 15 Jan 2026 | Viewed by 53 | Submission Open
Keywords: complex PCI; calcium modification; left main stem; stent; coronary artery disease; atherectomy; mechanical circula-tory support device; Impella; DCB; intra-coronary imaging; IVUS; OCT
(This special issue belongs to the Section Cardiology)
Chronic Kidney Disease: Current Challenges and Adverse Outcomes
edited by and Flaviu Bob
submission deadline 15 Jan 2026 | Viewed by 52 | Submission Open
Keywords: chronic kidney disease; CKD progression; hemodialysis; cardiovascular complications; vascular calcification; lifestyle; nutrition; bone and mineral disorders; CKD-associated osteoporosis; mortality
(This special issue belongs to the Section Nephrology & Urology)
Pulmonary Critical Care: Diagnosis and Treatment of Respiratory System Diseases
edited by Yaron Bar-Lavie
submission deadline 15 Jan 2026 | Viewed by 50 | Submission Open
Keywords: acute respiratory distress syndrome (ARDS); mechanical ventilation; chronic obstructive pulmonary disease (COPD); sepsis-induced lung injury; pulmonary fibrosis; bronchoscopy in critical care
(This special issue belongs to the Section Intensive Care)
Clinical Updates on Epilepsy Researches submission deadline 15 Jan 2026 | Viewed by 49 | Submission Open
Keywords: epilepsy; autoimmune epilepsy; neural autoantibodies; seizure disorders; experimental epilepsy models; animal studies; neuronal excitability; immunotherapy; predictive scoring systems; epilepsy biomarkers
(This special issue belongs to the Section Clinical Neurology)
Advances in Oculoplastic Surgery and Ocular Surface Diseases
edited by Michael T. Yen, Francesco Quaranta Leoni and
submission deadline 15 Jan 2026 | Viewed by 46 | Submission Open
Keywords: ocular surface disease; corneal neurotization; neurotrophic keratopathy; eyelid malposition; facial nerve palsy; thyroid eye disease; oculoplastic surgery; hemocomponents; dry anophthalmic socket; corneal pathology; ocular surface reconstruction; exposure keratopathy
(This special issue belongs to the Section Ophthalmology)
Insights into Acute Pancreatitis: Pathogenesis, Diagnosis, and Management
edited by Gil Nissim Bachar and Ram Dickman
submission deadline 15 Jan 2026 | Viewed by 42 | Submission Open
Keywords: acute pancreatitis; pancreatic inflammation; necrotizing pancreatitis; clinical outcomes; ultrasound examination
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Diagnosis and Management of Chronic Venous Diseases submission deadline 15 Jan 2026 | Viewed by 29 | Submission Open
Keywords: varicose veins; chronic venous insufficiency; pathogenesis; operative treatment; conservative treatment; profilaxis
(This special issue belongs to the Section Vascular Medicine)
Artificial Intelligence in Gastrointestinal Disorders: Current Updates from Theory to Clinical Practice submission deadline 15 Jan 2026 | Viewed by 21 | Submission Open
Keywords: artificial intelligence; gastroenterology; medical imaging; endoscopy; prognostic modeling; ethical considerations
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Novel Sepsis and Post-Sepsis Care: The Heart and Beyond
edited by Alexander Liu and Barbara J. Philips
submission deadline 16 Jan 2026 | Viewed by 68 | Submission Open
Keywords: sepsis; post sepsis; inflammation; cardiomyopathy; heart failure; cardiac imaging; biomarkers; novel therapies; prognosis; clinical outcomes
Innovations in Plastic and Reconstructive Research
edited by Damiano Tambasco and Roberta Albanese
submission deadline 18 Jan 2026 | 3 articles | Viewed by 2173 | Submission Open
Keywords: microvascular surgery; 3D printing; regenerative medicine; aesthetic surgery; minimally invasive techniques
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
New Advances in Hip and Knee Arthroplasty
edited by Jun-Dong Chang
submission deadline 18 Jan 2026 | Viewed by 25 | Submission Open
Keywords: hip arthroplasty; knee arthroplasty; joint replacement; revision surgery; orthopedic implants; robotic surgery; peri-operative care; functional outcomes; complication management; orthopedic innovation
(This special issue belongs to the Section Orthopedics)
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