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Targeted Medicine in Postoperative Pain Management
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Targeted Medicine in Postoperative Pain Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 954

Special Issue Editors

Dr. Martina Rekatsina

E-Mail Website
Guest Editor
Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
Interests: chronic pain management; acute pain management; regional anaesthesia; anaesthesia; perioperative care
Dr. Eleni Moka

E-Mail Website
Guest Editor
Anaesthesiology Department, Creta Interclinic Hospital, Hellenic Healthcare Group (HHG), Heraklion, Crete, Greece
Interests: regional anaesthesia; acute pain management; cardiothoracic anaesthesia; anaesthesiology; enhanced recovery after surgery; perioperative care
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, "Targeted Medicine in Postoperative Pain Management", aims to provide a comprehensive platform for the latest advancements and innovations in the field of postoperative pain management. This collection seeks to explore targeted therapeutic approaches, precision medicine, and personalized interventions aimed at optimizing pain control and patient outcomes following surgical procedures.

This Special Issue welcomes original research articles, reviews, and clinical studies focusing on novel pharmacological agents, precision drug delivery systems, and individualized treatment regimens for postoperative pain.

By fostering a deeper understanding of targeted medicine in postoperative pain management, this Special Issue endeavors to advance clinical practice and improve the quality of care for surgical patients.

Dr. Martina Rekatsina
Dr. Eleni Moka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • precision medicine
  • postoperative analgesia
  • pain control
  • drug delivery systems
  • surgical pain management
  • personalized interventions

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Published Papers (1 paper)

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Research

19 pages, 1153 KiB  
Article
Prefrontal Cortical Near-Infrared Spectroscopy for Acute Pain Assessment in Infants: A Feasibility Study
by Matthias Nissen and Ralf-Bodo Tröbs
J. Clin. Med. 2025, 14(7), 2525; https://doi.org/10.3390/jcm14072525 - 7 Apr 2025
Viewed by 530
Abstract
Background: Assessing pain in infants is challenging due to their inability to communicate discomfort. Accurate pain evaluation is essential, as unaddressed pain might lead to long-term neurological consequences. This study investigates the use of conventional two-site near-infrared spectroscopy (NIRS) to evaluate hemodynamic responses [...] Read more.
Background: Assessing pain in infants is challenging due to their inability to communicate discomfort. Accurate pain evaluation is essential, as unaddressed pain might lead to long-term neurological consequences. This study investigates the use of conventional two-site near-infrared spectroscopy (NIRS) to evaluate hemodynamic responses in the prefrontal cortex during nociceptive stimuli. Methods: Data were prospectively collected from ten infants undergoing elective heel lance/squeeze (HLS) after surgery. Continuous bilateral NIRS oxygenation monitoring was performed alongside cardiorespiratory and behavioral (Children’s and Infant’s Postoperative Pain Score (CHIPPS)) pain assessments before, during, and after HLS. The primary outcome was the correlation between NIRS response and CHIPPS. Results: The average gestational and postnatal ages were 39 weeks and 49 days. No significant changes in prefrontal oxygenation levels (left, right, combined, ipsilateral, contralateral) were observed during the first ten seconds of HLS compared with baseline. Although CHIPPS and heart rates increased, oxygenation levels remained unchanged throughout the entire HLS event. Significant fluctuations in oxygenation levels from baseline were recorded across all optode configurations, with changes in the lowest oxygenation levels at the contralateral and left hemispheres inversely correlated with CHIPPS and HR changes. Conclusions: While there were subtle alterations in NIRS signals suggesting potential nociceptive-evoked changes, these were inconclusive. By design, the utilized two-site conventional NIRS system may not effectively detect acute pain. Future studies on prefrontal cortical pain processing could benefit from confirmatory NIRS signals from the primary somatosensory and motor regions. Integrating data from fNIRS, fMRI, EEG, along with sympathetic indicators like skin conductance and heart rate variability, would improve the quantification of cortical pain processing in non-verbal infants. Full article
(This article belongs to the Special Issue Targeted Medicine in Postoperative Pain Management)
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