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Advances in the Management of Oral Lichen Planus: A Comprehensive Clinical Perspective

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 407

Special Issue Editors


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Guest Editor
Department of Dental Surgery, Periodontology and Oral Mucosa Diseases, Poznan University of Medical Sciences, 70 Bukowska St., 60-812 Poznan, Poland
Interests: oral pathology; oral diseases; diseases of the oral mucosa; periodontology

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Guest Editor
Department of Integrated Dentistry, Poznan University of Medical Sciences, 60-812 Poznan, Poland
Interests: clinical trials in preventive dentistry; salivary research; remineralization; oral biology in neuropsychiatry
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Special Issue Information

Dear Colleagues,

Oral lichen planus (OLP) is a common mucocutaneous disease with an uncertain etiology. To date, the background of the condition remains unclear, but most likely, it involves both antigen-specific and non-specific mechanisms, leading to the damage of the basal cell layer in the epithelium. Remissions and exacerbations modified by several environmental factors strongly reduce the quality of life of patients with OLP. The disease was identified as a potentially malignant disorder by the World Health Organization. The treatment of OLP is mainly symptomatic, with no effective causative therapeutic options currently available.

In this Special Issue, we welcome authors to submit papers focused on the management of oral lichen planus. A comprehensive perspective, including current treatment options as well as novel and emerging options, will be presented in this series.

We encourage all authors to share their experiences on this topic for this Special Issue as there is an urgent need to develop effective therapeutic strategies for patients with OLP and to develop a uniform strategy for its management. 

Dr. Zuzanna Ślebioda
Prof. Dr. Elzbieta Paszynska
Guest Editors

Manuscript Submission Information

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Keywords

  • oral lichen planus
  • treatment
  • topical treatment
  • systemic treatment
  • oral mucosa
  • oral pathology
  • immunosuppressive therapy

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Published Papers (1 paper)

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Research

15 pages, 2550 KiB  
Article
The Association Between Supragingival Plaque Microbial Profiles and the Clinical Severity of Oral Lichen Planus Subtypes: A Cross-Sectional Case–Control Study
by Soo-Min Ok, Hye-Min Ju, Sung-Hee Jeong, Yong-Woo Ahn, Ji-Young Joo, Jung Hwa Park, Si Yeong Kim, Jin Chung and Hee Sam Na
J. Clin. Med. 2025, 14(14), 5078; https://doi.org/10.3390/jcm14145078 - 17 Jul 2025
Viewed by 190
Abstract
Background/Objective: Oral lichen planus (OLP) is a chronic inflammatory disorder of the oral mucosa with unclear etiology. Increasing evidence implicates oral microbial dysbiosis in its pathogenesis, but little is known about supragingival plaque communities in relation to clinical subtypes. This cross-sectional case–control [...] Read more.
Background/Objective: Oral lichen planus (OLP) is a chronic inflammatory disorder of the oral mucosa with unclear etiology. Increasing evidence implicates oral microbial dysbiosis in its pathogenesis, but little is known about supragingival plaque communities in relation to clinical subtypes. This cross-sectional case–control study aimed to characterize the supragingival plaque microbiota and microbial interaction networks in erosive OLP (E-OLP), non-erosive OLP (NE-OLP), and healthy controls (HCs), to elucidate microbial patterns associated with disease severity. Methods: Supragingival plaque samples were collected from 90 participants (30 per group) and analyzed using 16S rRNA gene sequencing. Alpha and beta diversity metrics, differential abundance, and co-occurrence network analyses were performed. Results: E-OLP exhibited pronounced dysbiosis, including the enrichment of pro-inflammatory taxa (e.g., Prevotella, Parvimonas) and depletion of health-associated commensals (e.g., Rothia, Capnocytophaga). Network analysis revealed the stepwise disintegration of microbial community structure from HC to NE-OLP to E-OLP, with reduced connectivity and increased dominance of pathogenic clusters in E-OLP. These microbial alterations aligned with clinical findings, as E-OLP patients showed significantly higher Reticulation/keratosis, Erythema, and Ulceration (REU) scores for erythema and ulceration compared to NE-OLP. Conclusions: Supragingival plaque dysbiosis and ecological disruption are strongly associated with OLP severity and subtype. This study highlights the utility of plaque-based microbial profiling in capturing lesion-proximal dysbiotic signals, which may complement mucosal and salivary analyses in future diagnostic frameworks. Multi-omics approaches incorporating fungal, viral, and metabolic profiling are warranted to fully elucidate host–microbe interactions in OLP. Full article
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