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Immunotherapy of Hematological Malignancies: The State of the Art

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1127

Special Issue Editors


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Guest Editor
Department of Pediatrics, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: pediatric hematology; bone marrow transplantation; bleeding disorders; coagulation disorders; general pediatrics
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Guest Editor
Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania
Interests: hematological malignancies; clinical hematology; flow cytometry; lymphoma; cancer diagnostics; cell culture; liver diseases; hematologic diseases; multiple myeloma; chemotherapy

Special Issue Information

Dear Colleagues,

Chemotherapy is not always effective enough and can have significant side effects; therefore, it is not indicated in some categories of patients (especially the elderly) due to its toxicities and their comorbidities. These are arguments that led to the emergence and development of immunotherapy. Its results have radically improved the evolution of many oncohematological diseases, and this trend continues in parallel with the improvement of production technologies and the expansion of the product range. Such types of immunotherapies are naked or ordinary monoclonal antibodies, antibody-drug conjugates, bi-specific T-cell engagers, adoptive cell transfer, including chimeric antigen receptor T-cells and chimeric antigen receptor-engineered natural killer cells, and immune checkpoint inhibitors. Unfortunately, the increasing use of immunotherapy and immunochemotherapy has dramatically increased the frequency of side effects, including life-threatening clinical manifestations and significant immunosuppression (with risk of infection or a new neoplasm).

Finding a balance between targeted immuno-chemotherapy and protecting the patient's immune system is the key to obtaining good results with the lowest possible risk of infections and secondary neoplasms.

This Special Issue, “Immunotherapy of Hematological Malignancies: The State of the Art", aims to provide an overview of current and developing immunotherapy treatments, endeavoring to give some answers to the many questions and concerns that exist and to facilitate the emergence of new research directions to improve therapeutic results.

Prof. Dr. Anca Colita
Prof. Dr. Romeo Gabriel Mihaila
Guest Editors

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Keywords

  • antibody-drug conjugates
  • bispecific antibodies
  • chimeric antigen receptor-engineered natural killer cell
  • chimeric antigen receptor T-cells
  • cytokine release syndrome
  • immune checkpoint in-hibitors
  • immunosuppression
  • immunotherapy
  • monoclonal antibodies
  • neurotoxicities

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Published Papers (1 paper)

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Review

16 pages, 1169 KiB  
Review
Bispecific Antibodies—A New Hope for Patients with Diffuse Large B-Cell Lymphoma
by Romeo Gabriel Mihaila and Samuel B. Todor
J. Clin. Med. 2025, 14(15), 5534; https://doi.org/10.3390/jcm14155534 - 6 Aug 2025
Viewed by 878
Abstract
T-cell-engaging antibodies are a promising new type of treatment for patients with refractory or relapsed (R/R) diffuse large B-cell lymphoma, which has changed the prognosis and evolution of these patients in clinical trials. Bispecific antibodies (BsAbs) bind to two different targets (B and [...] Read more.
T-cell-engaging antibodies are a promising new type of treatment for patients with refractory or relapsed (R/R) diffuse large B-cell lymphoma, which has changed the prognosis and evolution of these patients in clinical trials. Bispecific antibodies (BsAbs) bind to two different targets (B and T lymphocytes) at the same time and in this way mimic the action of CAR (chimeric antigen receptor) T-cells. They are the T-cell-engaging antibodies most used in practice and are a solution for patients who do not respond to second- or later-line therapies, including chemoimmunotherapy, followed by salvage chemotherapy and hematopoietic stem cell transplantation. They are a therapeutic option for patients who are ineligible for CAR T-cell therapy and are also active in those with prior exposure to CAR T-cell treatment. A remarkable advantage of BsAbs is their rapid availability, even if the disease progresses rapidly, unlike CAR T-cell treatment, and they avoid the practical and financial challenges raised by autologous CAR T-cell therapies. CAR-T has been proven to have better efficacy compared to BsAbs, but cytokine release syndrome and neurotoxicity have appeared significantly more frequently in patients treated with CAR T-cells. The possibility of combining BsAbs with chemotherapy and their administration for relapses or as a frontline therapy is being studied to increase their efficacy. BsAbs are a life-saving therapy for many patients with diffuse large B-cell malignant non-Hodgkin’s lymphoma (NHL) who have a poor prognosis with classical therapies, but are not without adverse effects and require careful monitoring. Full article
(This article belongs to the Special Issue Immunotherapy of Hematological Malignancies: The State of the Art)
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