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Neuropathic Pain: From Prevention to Diagnosis and Management
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Neuropathic Pain: From Prevention to Diagnosis and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 303

Special Issue Editor

Dr. Enrico Martin

E-Mail Website
Guest Editor
Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Interests: neuro-oncology; peripheral nerve surgery; plastic and reconstructive surgery; surgical oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neuropathic pain remains a significant clinical challenge, affecting millions worldwide and often proving refractory to conventional treatments. As our understanding of its complex pathophysiology continues to evolve, the need for innovative research spanning both clinical and preclinical domains has never been more pressing. This Special Issue of the Journal of Clinical Medicine aims to provide a comprehensive platform for cutting-edge research that advances our knowledge of neuropathic pain mechanisms, diagnostic strategies, and therapeutic interventions.

We invite researchers, clinicians, and industry professionals to contribute original research articles, systematic reviews/meta-analyses, and translational studies that address key aspects of neuropathic pain. Topics of interest include, but are not limited to, novel pharmacological and non-pharmacological treatment approaches, biomarkers for early diagnosis and prognosis, neuroinflammatory and neuroimmune contributions to pain, and the role of genetic and epigenetic factors in pain susceptibility and treatment response. Studies exploring new surgical techniques, outcome measurements, or emerging technologies, such as neuromodulation and machine learning applications in pain assessment, are also highly encouraged.

By fostering collaboration across disciplines, this Special Issue seeks to bridge the gap between basic science discoveries and clinical applications, ultimately aiming to improve patient outcomes. We look forward to your valuable contributions that will help shape the future of neuropathic pain research and management.

Dr. Enrico Martin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuropathic pain
  • clinical research
  • TMR
  • RPNI
  • preclinical studies
  • QoL
  • PROMS
  • translational medicine
  • pain mechanisms

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Published Papers (1 paper)

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Review

14 pages, 983 KiB  
Review
Double Crush Syndrome of the L5 Nerve Root and Common Peroneal Nerve at the Fibular Head: A Case Series and Review of the Literature
by Hugo F. den Boogert, Janneke Schuuring and Godard C. W. de Ruiter
J. Clin. Med. 2025, 14(14), 5023; https://doi.org/10.3390/jcm14145023 - 16 Jul 2025
Viewed by 173
Abstract
Background/Objectives: The co-existence of multiple compression sites on the same nerve can pose a clinical and diagnostic challenge, warranting a different treatment strategy. This so-called double crush syndrome (DCS) has mainly been investigated in the upper limb. Only a few studies have [...] Read more.
Background/Objectives: The co-existence of multiple compression sites on the same nerve can pose a clinical and diagnostic challenge, warranting a different treatment strategy. This so-called double crush syndrome (DCS) has mainly been investigated in the upper limb. Only a few studies have investigated DCS for the lower limb. In this article, a single-center illustrative clinical case series is presented, and current literature on L5 nerve root (NR) and concomitant common peroneal nerve (CPN) is reviewed. Methods: All patients presenting between 2019 and 2022 with L5 nerve root (NR) compression and, along their clinical courses, concomitant compression of the common peroneal nerve (CPN) at the fibular head were included. Information on clinical features, diagnostics and surgeries was obtained. The outcome was assessed at the last outpatient follow-up appointment. In addition, an extensive literature review has been conducted. Results: Fourteen patients were included with a mean follow-up of 6.8 months. The majority had pain (71%) or motor deficits (71%). Seven patients were referred for clinical and radiological L5 NR compression but were also found to have CPN compression; the other seven patients had persisting or recurrent symptoms after surgically or conservatively treated L5 NR compression, suggestive of additional peroneal neuropathy. All patients had CPN decompression at the fibular head, with successful results obtained in 93% of the patients. Pain of the lower leg improved in all patients, and dorsiflexion function improved in 78%. Conclusions: Concomitant L5 NR and CPN appear to occur more frequently than expected. Peroneal neuropathy can present simultaneously with L5 nerve radiculopathy or after surgically or conservatively treated L5 NR compression. Overlapping symptoms and variation in clinical presentations make it difficult to diagnose and, therefore, underrecognized. More awareness among treating physicians of this specific double crush syndrome is important to prevent any delay in treatment, in this case, a less invasive common peroneal nerve release at the fibular head, and to avoid unnecessary (additional) spinal surgery. Full article
(This article belongs to the Special Issue Neuropathic Pain: From Prevention to Diagnosis and Management)
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