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Total Joint Arthroplasty: Clinical Advances and Innovations in Surgical Techniques...
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Total Joint Arthroplasty: Clinical Advances and Innovations in Surgical Techniques and Rehabilitation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 721

Special Issue Editors

Dr. Marco Minelli

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Guest Editor
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy
Interests: hip arthroplasty; knee arthroplasty; hip arthroscopy
Prof. Dr. Mattia Loppini

E-Mail Website
Guest Editor
1. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy
2. IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy
Interests: hip and knee primary arthroplasty; hip and knee revision arthroplasty; hip arthroscopy; hip osteotomies; periprosthetic joint infection; fast-track; artificial intelligence; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Federico Della Rocca

E-Mail
Guest Editor
IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Interests: hip arthroplasty; knee arthroplasty; hip arthroscopy

Special Issue Information

Dear Colleagues,

Total joint arthroplasty (TJA) remains one of the most effective surgical interventions for end-stage joint disease, significantly improving pain, function, and quality of life. Recent years have seen rapid evolution in surgical techniques, implant design, perioperative care, and rehabilitation protocols that continue to refine outcomes and reduce complications. This Special Issue aims to highlight current clinical advances and emerging innovations in TJA, including minimally invasive procedures, robotic-assisted surgery, enhanced recovery after surgery (ERAS) pathways, and patient-specific rehabilitation strategies. We welcome original research articles, reviews, and clinical studies that explore the efficacy, safety, and long-term outcomes of novel approaches in hip, knee, shoulder, and other joint arthroplasties. Contributions discussing challenges such as periprosthetic joint infection, implant longevity, patient selection, and postoperative monitoring are also encouraged. By bringing together cutting-edge research and expert perspectives, this Special Issue seeks to inform clinical practice and foster multidisciplinary collaboration in the evolving landscape of joint replacement surgery.

Dr. Marco Minelli
Prof. Dr. Mattia Loppini
Dr. Federico Della Rocca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • total joint arthroplasty
  • hip replacement
  • knee arthroplasty
  • robotic-assisted surgery
  • minimally invasive techniques
  • implant design
  • postoperative rehabilitation
  • periprosthetic joint infection
  • surgical innovation

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Published Papers (1 paper)

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Research

14 pages, 2366 KB  
Article
Minimum Two-Year Outcomes of the Zimmer G7 Modular Dual Mobility Cup in Primary Total Hip Arthroplasty: Survivorship, Complications, Clinical and Radiographic Results
by Marco Minelli, Vincenzo Longobardi, Vincenzo Paolo Di Francia, Alessio D’Addona, Marco Rosolani and Federico Della Rocca
J. Clin. Med. 2025, 14(19), 7071; https://doi.org/10.3390/jcm14197071 - 7 Oct 2025
Viewed by 623
Abstract
Background/Objectives: Modular dual mobility (MDM) cups are constituted by a cobalt-chromium liner inserted into a standard acetabular shell, allowing for intraoperative indication and supplementary screw fixation of the acetabular component. MDM could face mechanical and biological issues, with the associated risk of elevated [...] Read more.
Background/Objectives: Modular dual mobility (MDM) cups are constituted by a cobalt-chromium liner inserted into a standard acetabular shell, allowing for intraoperative indication and supplementary screw fixation of the acetabular component. MDM could face mechanical and biological issues, with the associated risk of elevated blood metal ions levels and adverse local tissue reactions. Methods: This is a monocentric retrospective study on a consecutive series of 105 patients who underwent primary unilateral THA with the G7 Dual Mobility Acetabular System cup (Zimmer Biomet, Warsaw, IN, USA) from March 2019 to April 2023, and who were evaluated clinically and radiographically at a minimum two-year follow-up. All complications and revisions were recorded. Survivorship analysis with any revision surgery as endpoint was performed using Kaplan–Meier survival curves. Results: There were eighty-nine patients (follow-up rate 84.8%) who underwent clinical and radiographic follow-up. The mean follow-up was 2.5 ± 0.8 years. Revision-free survival was 98.0%. Three complications (2.8%) were recorded: one case of posterior dislocation, one periprosthetic joint infection and one post-traumatic periprosthetic femur fracture. Dislocation rate and infection rate were less than 1.0%. None of the patients were revised for adverse local tissue reactions. No cup loosening was observed. No cases of intraprosthetic dislocation, liner malseating or femoral notching were observed. Retroacetabular stress shielding was present in 43.0% of patients. Clinical scores significantly improved at the last follow-up compared with preoperative status (p < 0.0001): the final mean mHHS was 87.5 ± 5.3 and the final mean VAS was 0.5 ± 0.9. Conclusions: The Zimmer G7 modular dual mobility cup appears to be a safe and effective option and does not present specific implant-related mechanical and biological issues in primary total hip arthroplasty at a minimum two-year follow-up. Full article
(This article belongs to the Special Issue Total Joint Arthroplasty: Clinical Advances and Innovations in Surgical Techniques and Rehabilitation)
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