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Periodontology and Dental Implants: State of the Art and Future Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 17 April 2026 | Viewed by 1029

Special Issue Editors


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Guest Editor
1. Section of Periodontics, School of Dentistry, Department of Surgical Specialties, Radiological Science and Public Health, University of Brescia, Brescia, Italy
2. U.O.C. Odontostomatologia - ASST degli Spedali Civili di Brescia, Brescia, Italy
Interests: periodontal and peri-implant tissue biology; regenerative therapies and biomaterials; implant surface design and functionalization; digital workflows and computer-assisted implantology; artificial intelligence and precision medicine in dentistry; oral microbiome and host–pathogen interactions; risk factors and predictive models for implant success; prevention, diagnosis, and management of peri-implant diseases; long-term outcomes and maintenance strategies; translational research and clinical innovations in periodontology and implantology

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Guest Editor
Department of Medicine and Technological Innovation, Research Center of Innovative Technology and Engineered Biomaterial, University of Insubria, 21100 Varese, Italy
Interests: implantology; biomechanics; prosthodontic rehabilitation; implant design
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Special Issue Information

Dear Colleagues,

Periodontology and dental implantology have undergone remarkable evolution over the past decades, driven by advances in biomaterials, regenerative strategies, digital technologies, and an improved understanding of host–microbe interactions. Today, the interplay between periodontal health and implant success is more evident than ever, with emerging concepts highlighting the critical role of precision diagnostics, personalized treatment planning, and long-term maintenance. Despite significant achievements, clinical and biological challenges remain, including peri-implant diseases, patient-specific risk factors, and the integration of new technologies into daily practice.

This proposed Special Issue, “Periodontology and Dental Implants: State of the Art and Future Perspectives”, aims to provide a comprehensive platform for disseminating cutting-edge research, critical reviews, and innovative clinical approaches in this rapidly advancing field. Contributions will address key topics such as tissue regeneration, implant surface modifications, digital workflows, risk assessment models, microbiome studies, and novel therapeutic strategies for peri-implantitis. By bridging basic science, clinical practice, and future innovations, this collection seeks to foster interdisciplinary dialog and stimulate new directions for research and patient care.

This Special Issue aspires to become a reference point for clinicians, researchers, and industry stakeholders, promoting evidence-based advancements and shaping the future of periodontology and implant dentistry.

Prof. Dr. Magda Mensi
Dr. Davide Farronato
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontology
  • dental implants
  • regenerative dentistry
  • peri-implant diseases
  • digital dentistry
  • implant surface modifications
  • tissue engineering
  • oral microbiome
  • risk assessment
  • personalized treatment

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Published Papers (1 paper)

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19 pages, 1261 KB  
Systematic Review
Release of Titanium Particles After Implantoplasty in the Treatment of Peri-Implantitis: Local and Systemic Implications—An Integrative Systematic Review
by Maria Belén Rodríguez Alvarez, Esteban Padullés-Roig, Guillermo Cabanes-Gumbau, J. A. Callejas-Cano and Javier Gil
J. Clin. Med. 2025, 14(24), 8661; https://doi.org/10.3390/jcm14248661 - 6 Dec 2025
Viewed by 776
Abstract
Background/Objectives: Implantoplasty is widely applied in the surgical management of peri-implantitis; however, this procedure releases titanium micro- and nanoparticles whose biological relevance remains uncertain. Understanding whether these particles influence peri-implant tissue health or systemic responses is essential for assessing the long-term safety of [...] Read more.
Background/Objectives: Implantoplasty is widely applied in the surgical management of peri-implantitis; however, this procedure releases titanium micro- and nanoparticles whose biological relevance remains uncertain. Understanding whether these particles influence peri-implant tissue health or systemic responses is essential for assessing the long-term safety of implantoplasty. To determine whether titanium particles generated during implantoplasty are associated with peri-implantitis, peri-implant tissue changes, or systemic effects. Methods: This systematic review followed PRISMA 2020 guidelines. Electronic searches were performed in PubMed, Scopus, and Cochrane Library for studies published between 2015 and 2025. Eligible in vitro, in vivo, observational, and clinical studies evaluated titanium particle release during or after implantoplasty and its local or systemic effects. Study selection and data extraction were conducted independently, and the risk of bias was assessed using RoB 2, ROBINS-I, and AMSTAR 2. Synthesis was qualitative due to heterogeneity. Certainty of evidence was evaluated with GRADE. Results: Fourteen studies met the inclusion criteria. Titanium particles ranging from 100 nm to 54 µm were consistently detected in peri-implant tissues, with higher levels in peri-implantitis sites, though without consistent clinical association. In vitro data showed dose-dependent inflammatory cytokine release and decreased osteogenic activity, whereas human studies did not confirm a direct relationship between particles and peri-implantitis or marginal bone loss. Certainty of evidence was generally low. Conclusions: Titanium particles generated during implantoplasty are detectable but show no consistent clinical association with peri-implantitis or significant inflammation. Implantoplasty may be applied selectively, although robust long-term clinical studies are still required. No protocol was registered. Full article
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