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Current Progress in Inflammatory Bowel Disease (IBD)
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Current Progress in Inflammatory Bowel Disease (IBD)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 1988

Special Issue Editors

Dr. Dan Lucian Dumitrascu

E-Mail Website
Guest Editor
2nd Department of Internal Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj County Clinical Emergency Hospital, 400006 Cluj-Napoca, Romania
Interests: disorders of gut brain interaction; psychosomatic medicine; inflammatory bowel diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Simona Grad

E-Mail Website
Guest Editor
2nd Department of Internal Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj County Clinical Emergency Hospital, 400006 Cluj-Napoca, Romania
Interests: inflammatory bowel disease

Special Issue Information

Dear Colleagues,

Many research endeavors have focused on inflammatory events in the gastrointestinal tract, leading to an improved understanding of its pathogenesis. Such advances will hopefully lead to the advent of new therapies and continue to refine the evaluations used within current interventions. Such progress should, in due course, lead to enhanced outcomes of individuals diagnosed with ulcerative colitis, Crohn disease and other inflammatory conditions in the gut. MDPI invites investigators involved in the study of inflammatory bowel disease (IBD) to contribute to this Special Issue of the Journal of Clinical Medicine, which is fully dedicated to IBD. Original research or high-quality reviews are welcome within any field of IBD research and clinical management.

Dr. Dan Lucian Dumitrascu
Dr. Simona Grad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • assessment and diagnosis of IBD
  • diet and nutrition in IBD
  • Microbiota and IBD
  • RCTs in IBD
  • new therapies in IBD
  • meta-analyses and systematic reviews in IBD
  • psychological impact and quality of life in IBD
  • imaging techniques in IBD
  • pathogenesis of IBD (including the impact of disrupted barrier function)

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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10 pages, 950 KiB  
Article
Adherence to the Mediterranean Diet in Paediatric Patients with Inflammatory Bowel Disease and Functional Abdominal Pain Disorders—Comparative Study
by Iulia Florentina Ţincu, Bianca Teodora Chenescu, Larisa Alexandra Duchi and Doina Anca Pleșca
J. Clin. Med. 2025, 14(6), 1971; https://doi.org/10.3390/jcm14061971 - 14 Mar 2025
Viewed by 463
Abstract
Background/Objectives: There is a limited body of evidence regarding dietary intake in children with inflammatory bowel disease despite increasing research about the nutritional implications in the disease pathogenesis. Functional abdominal pain disorders (FAPDs) are also chronic disorders marked by chronic abdominal pain, currently [...] Read more.
Background/Objectives: There is a limited body of evidence regarding dietary intake in children with inflammatory bowel disease despite increasing research about the nutritional implications in the disease pathogenesis. Functional abdominal pain disorders (FAPDs) are also chronic disorders marked by chronic abdominal pain, currently described with the ROME IV criteria. This study was aimed to investigate the adherence to healthy eating habits in an inflammatory bowel disease pediatric population when compared to a matched population with functional abdominal pain gastrointestinal disorders. Methods: We performed a single centre study focused on dietary patterns in children with IBD and FAPDs between January 2021 and April 2024. Data collected included general information, disease phenotype, and the KIDMED index regarding healthy eating. Results: The final analysis was based on full data from the KIDMED index available for 122 (57 vs. 65) participants. Overall, the average KIDMED score did not vary significantly between the study population, meaning 6.89 ± 2.33 for the IBD group and 7.11 ± 2.67 for FAPDs group, p = 0.34. In the same KIDMED index group, mean values were higher for FAPDs patients, but results differ statistically significant only for “medium” adherence to healthy diet, showing that larger proportion of IBD patients were previously exposed to non-healthy diets: 8.99 vs. 11.1, p = 0.45, 5.02 vs. 6.92, p = 0.05, 2.89 vs. 2.56, p = 0.43, for group 1, 2, and 3, respectively. Conclusions: This study showed in our cohort that overall adherence to a healthy pattern diet is poor prior to diagnosis of different gastrointestinal pathologies in children. Full article
(This article belongs to the Special Issue Current Progress in Inflammatory Bowel Disease (IBD))
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14 pages, 5111 KiB  
Systematic Review
Sex-Based Disparities in Treatment and Healthcare Utilization in Patients with Ulcerative Colitis: A Systematic Review and Meta-Analysis
by Yash R. Shah, Sneha Annie Sebastian, Dushyant Singh Dahiya, Manesh Kumar Gangwani, Jinendra Satiya, Adishwar Rao, Ramy Mansour, Hassam Ali, Omar Al Ta’ani, Sumant Inamdar, Meer A. Ali and Mohammad Alomari
J. Clin. Med. 2024, 13(24), 7534; https://doi.org/10.3390/jcm13247534 - 11 Dec 2024
Viewed by 1050
Abstract
Background: Sex-related treatment disparities are well-documented across various medical conditions, yet their impact on the management of inflammatory bowel disease (IBD) remains underexplored. This study aims to investigate sex-based differences in the management of ulcerative colitis (UC), focusing on both medical and [...] Read more.
Background: Sex-related treatment disparities are well-documented across various medical conditions, yet their impact on the management of inflammatory bowel disease (IBD) remains underexplored. This study aims to investigate sex-based differences in the management of ulcerative colitis (UC), focusing on both medical and surgical approaches and examining whether biological sex correlates with variations in healthcare utilization. Methods: A systematic search was conducted across multiple databases, including MEDLINE (via PubMed), Google Scholar, the Cochrane Library, and ScienceDirect, to identify studies on sex differences in ulcerative colitis (UC) management up to April 2024. Statistical analysis was performed using RevMan 5.4, with a random-effects model to combine odds ratios (OR) for both primary and secondary outcomes. The study is registered with PROSPERO (CRD42024537750). Results: The meta-analysis included eight observational studies involving 47,089 patients (51.9% females). There were no statistically significant sex differences in biologic therapy use (OR 0.89, 95% CI: 0.69 to 1.15, p = 0.36) or corticosteroid use (OR 1.17, 95% CI: 0.89 to 1.54, p = 0.27). However, females were less likely to use immunomodulators compared to males (OR 0.89, 95% CI: 0.85 to 0.94, p < 0.0001). There were no significant differences in surgical interventions, including total abdominal colectomy. Females had higher annual UC-related hospitalizations compared to males (OR 1.41, 95% CI: 1.22 to 1.64, p < 0.00001). Conclusions: In conclusion, while biologic and surgical treatments showed no significant sex differences, disparities were noted in immunomodulator use and hospitalization rates, underscoring the need for sex-specific UC management strategies. Full article
(This article belongs to the Special Issue Current Progress in Inflammatory Bowel Disease (IBD))
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