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Imaging in Diagnosis and Treatment of Musculoskeletal Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nuclear Medicine & Radiology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 412

Special Issue Editors


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Guest Editor
Section of Rheumatology, Interdisciplinary Pain Medicine Unit, Santa Maria Maddalena Hospital, Rovigo, Italy
Interests: rheumatology; musculoskeletal ultrasound; musculoskeletal imaging; pain medicine; ultrasound guided procedures

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Guest Editor
Faculty of Medicine, Univeristy of Medicine and Pharmacy of Craiova, Craiova, Romania
Interests: rheumatology; musculoskeletal ultrasound; arthritis; osteoarthritis
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Special Issue Information

Dear Colleagues,

In the field of musculoskeletal disorders, imaging is becoming increasingly important in diagnostic confirmation, prognostic stratification, decision-making, and follow-up. The integration of imaging into the management of rheumatological conditions enables earlier diagnosis and more accurate differential diagnosis and ultimately offers a comprehensive understanding of the disease.

On the other hand, even in musculoskeletal disorders that are not exclusively of rheumatological origin, imaging has become a crucial tool, and making decisions without it would now seem outdated. Additionally, it is now widely established that imaging plays a vital role in interventional procedures, which, over the years, have become safer and increasingly precise thanks to the ability to guide needles to a target without crossing critical structures.

This concept applies equally to ultrasound-guided procedures, which can be routinely performed in an outpatient setting, as well as to fluoroscopy- or CT-guided procedures that require access to more specialized facilities.

For this Special Issue, we encourage authors to submit papers on applications of imaging in musculoskeletal and rheumatological conditions, in both diagnosis and treatment.

Dr. Francesco Porta
Prof. Dr. Florentin Ananu Vreju
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ultrasound
  • ultrasound-guided injections
  • imaging-guided procedures

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Published Papers (1 paper)

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Review

18 pages, 4138 KiB  
Review
Fibromyalgia in the Era of Brain PET/CT Imaging
by Elisabetta Abenavoli, Valentina Berti, Matilde Nerattini, Piercarlo Sarzi-Puttini, Georgios Filippou, Alessandro Lucia, Gilberto Pari, Stefano Pallanti, Fausto Salaffi, Marina Carotti, Silvia Sirotti and Francesco Porta
J. Clin. Med. 2025, 14(12), 4166; https://doi.org/10.3390/jcm14124166 - 12 Jun 2025
Viewed by 232
Abstract
Fibromyalgia syndrome (FMS) is a complex, heterogeneous disorder characterized by chronic widespread pain, fatigue, and cognitive disturbances. The multifactorial nature of FMS, with the involvement of central and peripheral mechanisms, hampers diagnosis and effective treatment. In recent years, positron emission tomography (PET) imaging [...] Read more.
Fibromyalgia syndrome (FMS) is a complex, heterogeneous disorder characterized by chronic widespread pain, fatigue, and cognitive disturbances. The multifactorial nature of FMS, with the involvement of central and peripheral mechanisms, hampers diagnosis and effective treatment. In recent years, positron emission tomography (PET) imaging has emerged as a valuable tool for exploring the neurobiological underpinnings of FMS. Several studies have investigated alterations in glucose metabolism, neurotransmitter systems (including opioid, dopamine, and GABAergic pathways), and neuroinflammation using various PET tracers. These findings have revealed distinct brain metabolic and molecular patterns in FMS patients compared to healthy controls, particularly in pain-related regions such as the thalamus, insula, and anterior cingulate cortex (ACC). Moreover, preliminary data suggest that PET imaging may help identify FMS subgroups with different pathophysiological profiles, potentially allowing for tailored therapeutic approaches. This review summarizes the current evidence on PET applications in FMS and discusses the potential role of molecular imaging in improving patient stratification and predicting treatment response. Full article
(This article belongs to the Special Issue Imaging in Diagnosis and Treatment of Musculoskeletal Disorders)
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