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Clinical Advances in Diabetes, Obesity, and Hypertension
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Clinical Advances in Diabetes, Obesity, and Hypertension

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 628

Special Issue Editors

Dr. Piotr Matłosz

E-Mail Website
Guest Editor
Department of Physical Culture Sciences, Medical College of Rzeszow University, 35-959 Rzeszow, Poland
Interests: health; anthropometry; obesity; physical activity; accelerometry
Special Issues, Collections and Topics in MDPI journals
Dr. Justyna Wyszyńska

E-Mail Website
Guest Editor
Institute of Health Sciences, Medical College of Rzeszów University, 35-959 Rzeszow, Poland
Interests: accelerometry; body composition; hypertension; obesity; physical activity; risk factors; sleep
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Obesity is a major risk factor for hypertension, cardiovascular disease, and type 2 diabetes, contributing to increased morbidity and mortality. The prevalence of these conditions varies between populations and is influenced by genetic, dietary, and lifestyle factors. The effective management of these conditions often requires a multidisciplinary approach, including lifestyle modifications, pharmacotherapy, and, in some cases, surgery.

Our aim in launching this Special Issue is to highlight the importance of a comprehensive understanding of the interplay between diabetes, obesity, and hypertension and to provide valuable insights for application in clinical practice by focusing on research advances in the prevalence, prevention, and effective treatment of hypertension, diabetes, and obesity and their complications.

Through this Special Issue, we aim to achieve the following:

  1. Explore the relationships between diabetes, obesity, and hypertension;
  2. Highlight recent clinical advances in the treatment and management of these conditions;
  3. Provide insights into the mechanisms underlying these diseases and their complications;
  4. Discuss the impact of lifestyle modifications, pharmacotherapy, and surgical interventions.

Dr. Piotr Matłosz
Dr. Justyna Wyszyńska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • hypertension
  • diabetes
  • lifestyle
  • physical activity
  • risk factors

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

13 pages, 537 KiB  
Article
High Prevalence of Metabolic-Associated Fatty Liver Disease (MAFLD) in Children and Adolescents with Severe Obesity
by Magdalena Mierzwa, Żaneta Malczyk, Mirosław Bik-Multanowski, Stephanie Brandt-Heunemann, Bertram Flehmig, Ewa Małecka-Tendera, Artur Mazur, Elżbieta Petriczko, Michael B. Ranke, Martin Wabitsch, Małgorzata Wójcik, Agata Domżol and Agnieszka Zachurzok
J. Clin. Med. 2025, 14(10), 3565; https://doi.org/10.3390/jcm14103565 - 20 May 2025
Viewed by 157
Abstract
Background: Severe obesity in children and adolescents presents a particular health burden due to high prevalence of complications and comorbidities, including metabolic-associated fatty liver disease (MAFLD). The aim of this study was to assess the prevalence of MAFLD in Polish children and [...] Read more.
Background: Severe obesity in children and adolescents presents a particular health burden due to high prevalence of complications and comorbidities, including metabolic-associated fatty liver disease (MAFLD). The aim of this study was to assess the prevalence of MAFLD in Polish children and adolescents with severe obesity, and assess its relation to anthropometric profiles and metabolic risk factors. Patients and Methods: In 212 children and adolescents with severe obesity (aged 3–18 years), physical examination, body composition, liver ultrasound (US), and biochemical assessment were performed. MAFLD was diagnosed based on the presence of steatosis in US and/or persistently elevated alanine aminotransferase concentration. Results: MAFLD was present in 125 (59.0%) patients. Metabolic Syndrome (MetS) was diagnosed among 57.5% of patients without MAFLD, and in 66.5% of patients with MAFLD (p > 0.05). Impaired fasting glucose, impaired glucose tolerance, and high HOMA-IR occurred more frequently in MAFLD than in non-MAFLD patients (p < 0.05). In the MAFLD group, a higher number of patients with ≥4 components of MetS were observed than in the non-MAFLD group (33.6% vs. 12.6%, p = 0.0004). Conclusions: The prevalence of MAFLD among children and adolescents with severe obesity was 59%. These patients are characterised by more pronounced insulin resistance and higher number of MetS components. Full article
(This article belongs to the Special Issue Clinical Advances in Diabetes, Obesity, and Hypertension)
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10 pages, 512 KiB  
Article
A New Score for Metabolic Age in Type 2 Diabetes Mellitus: Physical Rating Score
by Hasan Esat Yücel, Tufan Ulcay, Özkan Görgülü, Ruken Öncü, Emre Uğuz and Erkan Dulkadiroğlu
J. Clin. Med. 2025, 14(9), 2868; https://doi.org/10.3390/jcm14092868 - 22 Apr 2025
Viewed by 301
Abstract
Background: Metabolic age (met-age), a risk marker, may vary within the same chronological age group. Its association with chronological age, waist/height ratio, obesity degree, body mass index (BMI), and physical rating score (PRS)—risk factors for type 2 diabetes—remains unexplored. Methods: A [...] Read more.
Background: Metabolic age (met-age), a risk marker, may vary within the same chronological age group. Its association with chronological age, waist/height ratio, obesity degree, body mass index (BMI), and physical rating score (PRS)—risk factors for type 2 diabetes—remains unexplored. Methods: A total of 122 type 2 diabetes patients (50 males, 72 females) were analyzed. Bioimpedance measurements were taken using the Tanita MC-780MA, alongside anthropometric data. Variables were compared, and correlations with met-age were assessed. Results: The met-age–chronological age difference was higher in females with type 2 diabetes (p < 0.001). Females also had higher BMI, obesity degree, fat mass, and waist/height ratio (p < 0.05), but lower waist/hip ratio (p < 0.001). Males showed higher PRS, muscle mass, and fat-free mass (p < 0.001). Met-age positively correlated with chronological age and negatively with PRS in both sexes (p < 0.05). According to the linear regression model, in females, the met-age was influenced positively by chronological age and waist/height ratio and negatively by PRS (R2 = 0.983). In males, it was positively influenced by chronological age, obesity grade, and BMI, but negatively by PRS (R2 = 0.974). Conclusions: Met-age correlates with chronological age and PRS in type 2 diabetes patients. It increases with advancing age and lower PRS, with waist/height ratio impacting females and BMI/obesity degree affecting males. Full article
(This article belongs to the Special Issue Clinical Advances in Diabetes, Obesity, and Hypertension)
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