Autoimmune Skin Diseases: Innovations, Challenges, and Opportunities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 421

Special Issue Editor


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Guest Editor
Department of Dermatology, Rabin Medical Center, Petah Tikva 4941492, Israel
Interests: vitiligo; hidradenitis suppurativa; psoriasis; population-based studies; immunology of skin diseases

Special Issue Information

Dear Colleagues,

The advent of biologic therapies has transformed the management of common inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa, leading to significant changes in drug utilization. While these treatments have greatly improved patient outcomes, they also present challenges, including an increasing economic burden on healthcare systems. This Special Issue will explore these challenges while addressing specific shifts in healthcare access, such as hospitalization rates, physician visits, and the emergence of comorbid conditions. Additionally, we will examine novel approaches to photodermatoses, such as solar urticaria and collagen vascular diseases, driven by advances in research on immunopathogenesis. A key focus will also be placed on recent developments in targeted therapies for immunobullous disorders and graft-versus-host disease, opening up new avenues for precision medicine. By integrating research on disease mechanisms, innovative treatment strategies, and healthcare impacts, this Special Issue will foster conversations around optimizing patient care and resource allocation in autoimmune dermatology.

Dr. Shany Sherman
Guest Editor

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Keywords

  • healthcare utilization
  • inflammatory skin diseases
  • photodermatoses
  • collagen vascular disease
  • immunobullous disorders
  • graft-versus-host disease

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Published Papers (1 paper)

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Research

11 pages, 460 KiB  
Article
Type 1 Diabetes/Hidradenitis Suppurativa Comorbidity—A Population-Based Study
by Shany Sherman, Ron Slama, Danielle Bar, Yochai Schonmann, Arnon D. Cohen, Yossef H. Taieb, Daniel Mimouni, Alon Peretz and Hadar Duskin-Bitan
J. Clin. Med. 2025, 14(8), 2625; https://doi.org/10.3390/jcm14082625 - 11 Apr 2025
Viewed by 306
Abstract
Background: Type 1 diabetes (T1D) and hidradenitis suppurativa (HS) share several metabolic and inflammatory dysfunctions. Prior studies of the potential link between the diseases either lacked validated T1D diagnoses or established only an indirect association. This study sought to determine the odds [...] Read more.
Background: Type 1 diabetes (T1D) and hidradenitis suppurativa (HS) share several metabolic and inflammatory dysfunctions. Prior studies of the potential link between the diseases either lacked validated T1D diagnoses or established only an indirect association. This study sought to determine the odds of HS developing in patients with a validated diagnosis of T1D and to characterize the clinical features of HS/T1D comorbidity. Methods: A population-based nested case-control study was conducted including patients with HS and controls matched 5:1 for age, sex, and primary care clinic. T1D was diagnosed using a specialized algorithm, achieving 90% accuracy. Diagnostic validity was confirmed by diabetes specialists who manually reviewed a random subset of the files. Unadjusted and adjusted odds ratios (OR/aOR) were calculated to determine the odds of incident HS in patients with T1D. Results: The study included 10,919 patients with HS and 53,314 controls. A history of T1D was associated with an elevated odds of new-onset HS (OR 1.80 95% CI (1.30–2.40), p < 0.001), even after adjusting for demographics and metabolic and autoimmune comorbidities (aORs > 1.7, p < 0.001). Patients with HS/T1D comorbidity had higher proportions of autoimmune conditions than patients with HS alone (p < 0.001) and a higher mean Charlson Comorbidity Index score than both patients with HS alone (3.5 vs. 0.9, p < 0.001) and T1D alone (3.5 vs. 2.2, p = 0.004). Conclusions: T1D is associated with higher odds of the subsequent development of HS. Awareness of HS/T1D comorbidity is recommended owing to the elevated burden of metabolic and autoimmune conditions. Full article
(This article belongs to the Special Issue Autoimmune Skin Diseases: Innovations, Challenges, and Opportunities)
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