Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
2.9
Journals
JCM
Special Issues
Clinical Management of Frailty
jcm-logo
Submit to Special Issue Submit Abstract to Special Issue Review for JCM Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Clinical Management of Frailty

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Geriatric Medicine".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 796

Special Issue Editors

Dr. Alejandro Alvarez-Bustos

E-Mail Website
Guest Editor
1. Biomedical Research Center Network for Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Av. Monforte de Lemos 3–5, 28029 Madrid, Spain
2. Instituto de Investigación Hospital Universitario La Paz (IdiPaz), C. de Pedro Rico 6, 28029 Madrid, Spain
Interests: frailty; sarcopenia; physical function; physical activity assessment; exercise; geriatric medicine; older adults
Special Issues, Collections and Topics in MDPI journals
Dr. Walter Sepulveda-Loyola

E-Mail Website
Guest Editor
Faculty of Health and Social Sciences, Universidad de Las Americas, Santiago, Chile
Interests: frailty; sarcopenia; fibromyalgia; pulmonary diseases; older adults; geriatric medicine
Dr. Isabel Rodríguez-Sánchez

E-Mail Website
Guest Editor
San Carlos Clinical University Hospital, Madrid, Spain
Interests: frailty; musculoskeletal pain; sarcopenia; fibromyalgia; older adults; geriatric medicine

Special Issue Information

Dear Colleagues,

Frailty is an age-associated syndrome characterized by a decline in quality of life and an increased susceptibility to adverse outcomes. For this reason, frailty is recognized as a major public health concern in the management of older adults.

In addition, recent advances in clinical research are reshaping our understanding of this complex disorder, offering new diagnostic tools, targeted interventions, and advances in monitoring.

This Special Issue aims to explore the state of the art regarding the multiple facets of frailty, including its identification, management through various interventions (nutritional, exercise, pharmacological, etc.) to prevent or mitigate it in different clinical contexts, and its association with negative health events in older adults.

Additionally, we highlight breakthroughs in early detection methods for frailty, including functional tests, blood biomarkers, and newly proposed diagnostic criteria designed to enhance the monitoring and management of age-related decline in physical resilience.

Addressing frailty is essential for preserving quality of life, extending healthy lifespan, and alleviating strain on healthcare systems. We invite contributions from researchers and clinicians at the forefront of this field to share insights that will shape future preventive and therapeutic strategies. Through scientific discourse and innovation, we aim to develop solutions that promote resilience and well-being in aging populations.

Dr. Alejandro Alvarez-Bustos
Dr. Walter Sepulveda-Loyola
Dr. Isabel Rodríguez-Sánchez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • frailty
  • comprehensive geriatric assessment
  • assessment
  • monitoring
  • functional decline
  • physical performance
  • ex-ercise interventions
  • nutritional strategies
  • interventions
  • adverse outcomes

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 732 KB  
Article
Gaming Against Frailty: Effects of Virtual Reality-Based Training on Postural Control, Mobility, and Fear of Falling Among Frail Older Adults
by Hammad S. Alhasan and Mansour Abdullah Alshehri
J. Clin. Med. 2025, 14(15), 5531; https://doi.org/10.3390/jcm14155531 - 6 Aug 2025
Viewed by 595
Abstract
Background/Objectives: Frailty is a prevalent geriatric syndrome associated with impaired postural control and elevated fall risk. Although conventional exercise is a core strategy for frailty management, adherence remains limited. Virtual reality (VR)-based interventions have emerged as potentially engaging alternatives, but their effects on [...] Read more.
Background/Objectives: Frailty is a prevalent geriatric syndrome associated with impaired postural control and elevated fall risk. Although conventional exercise is a core strategy for frailty management, adherence remains limited. Virtual reality (VR)-based interventions have emerged as potentially engaging alternatives, but their effects on objective postural control and task-specific confidence in frail populations remain understudied. This study aimed to evaluate the effectiveness of a supervised VR training program using the Nintendo Ring Fit Plus™ on postural control, functional mobility, and balance confidence among frail community-dwelling older adults. Methods: Fifty-one adults aged ≥65 years classified as frail or prefrail were enrolled in a four-week trial. Participants were assigned to either a VR intervention group (n = 28) or control group (n = 23). Participants were non-randomly assigned based on availability and preference. Outcome measures were collected at baseline and post-intervention. Primary outcomes included center of pressure (CoP) metrics—sway area, mean velocity, and sway path. Secondary outcomes were the Timed Up and Go (TUG), Berg Balance Scale (BBS), Activities-specific Balance Confidence (ABC), and Falls Efficacy Scale–International (FES-I). Results: After adjusting for baseline values, age, and BMI, the intervention group showed significantly greater improvements than the control group across all postural control outcomes. Notably, reductions in sway area, mean velocity, and sway path were observed under both eyes-open and eyes-closed conditions, with effect sizes ranging from moderate to very large (Cohen’s d = 0.57 to 1.61). For secondary outcomes, significant between-group differences were found in functional mobility (TUG), balance performance (BBS), and balance confidence (ABC), with moderate-to-large effect sizes (Cohen’s d = 0.53 to 0.73). However, no significant improvement was observed in fear of falling (FES-I), despite a small-to-moderate effect size. Conclusions: A supervised VR program significantly enhanced postural control, mobility, and task-specific balance confidence in frail older adults. These findings support the feasibility and efficacy of VR-based training as a scalable strategy for mitigating frailty-related mobility impairments. Full article
(This article belongs to the Special Issue Clinical Management of Frailty)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop