New Molecular Mechanisms of Genotoxicity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 612
Special Issue Editors
Interests: genetic toxicology; environmental mutagenesis; molecular mechanisms genotoxicity; DNA damage; DNA repair; chromosome malsegregation; aneuploidy
Interests: cell culture methods; genotoxicity assays; cell death and proliferation; radiobiology; DNA damage response
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mutations occur continuously in somatic and germ cells, triggered by biological processes associated with the metabolism of DNA. Besides endogenous factors, exogenous genotoxic agents may raise the burden of DNA damage, changing nucleotide sequences or chromosomal structures. Multiple cellular mechanisms provide guarantees that DNA damage can be detected and repaired to maintain genomic stability, since mutation accumulation contributes to the process of aging and carcinogenesis. In addition, mutations play a role in the pathogenesis of other chronic degenerative diseases such as neurodegeneration, cardiopathies, reproduction and development defects, severely damaging human health. Disclosing and dissecting the molecular mechanisms causing DNA damage increases the chances for the early detection of such diseases and advances scientific knowledge in the search for effective treatments.
This Special Issue will collect up-to-date information on the molecular mechanisms of genotoxicity. This research could be valuable for better preventing an increase in the burden posed by mutations and identifying genotoxic compounds, thus enabling actions that reduce safety concerns for human health.
Dr. Francesca Marcon
Dr. Roberta Meschini
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- DNA damage
- DNA repair
- genotoxicity
- carcinogenesis
- chronic degenerative diseases
- human health
- molecular mechanisms
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