Role of Mesenchymal Stem/Stromal Cells (MSCs) in Human Diseases and Their Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 31
Special Issue Editor
Interests: stem cells (and MSCs, in particular); mitochondria; macrophages; brain and lung injury; sepsis; ischemia-reperfusion; TGFβ pathways; translational research and clinical studies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to announce the Special Issue “Role of Mesenchymal Stem/Stromal Cells (MSCs) in Human Diseases and Their Treatment”, which will be published in the International Journal of Molecular Sciences (ISSN 1422-0067; 2024 Impact Factor 4.9 and CiteScore 9.0), and would like to invite you to submit a paper to this issue. The main scope of the issue is to highlight the current state of knowledge of molecular mechanisms by which MSCs act in health and disease, exhibit potent paracrine properties, regulate host immune responses and inflammation, interact with the environment, and orchestrate tissue repair at both the local and systemic levels. MSC immunomodulatory, anti-fibrotic, and regenerative properties are mainly regulated through cytokines, microvesicles, and growth factors. Their therapeutic properties could be potentiated by genetic modifications and preconditioning. However, understanding side effects and better strategies to overcome challenges regarding cell engraftment, cryopreservation, cell growth and viability, cell sources, and appropriate dosage are critical to improving MSC therapeutic efficacy. Ever-increasing knowledge of the above-mentioned strategies will optimize MSC use and allow for a personalized cell treatment approach.
In this issue, we welcome original research and up-to-date review papers. Generally, pure clinical research or model studies, survey studies, and correlation research are out of the scope of IJMS. However, clinical or model submissions with biomolecular experiments are welcomed.
Dr. Mirjana Jerkic
Guest Editor
Manuscript Submission Information
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Keywords
- mesenchymal stem/stromal cells (MSCs)
- MSC homing
- MSC properties
- immune cells
- macrophages
- injury
- inflammation
- cell therapy
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