Oxidative Stress and Disease: Basic and Biochemical Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 25 November 2025 | Viewed by 424
Special Issue Editor
Interests: biochemistry; veterinary medicine; molecular biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pollution, smoking, excessive alcohol consumption, and stress (external factors), in addition to metabolic processes in cells, such as respiration and digestion, produce many reactive oxygen species (ROS) and nitrogen species every day. These unstable molecules cause oxidative stress, an imbalance between ROS and nitrogen species in the cell, and affect its ability to neutralize them. Oxidative stress has detrimental effects, such as the onset of inflammatory processes and/or causing damage to cellular proteins, lipids, and nucleic acids. These negative effects must be counteracted by antioxidant biochemical pathways.
Moreover, oxidative stress is implicated in the development of diseases, including cancer, and many studies have investigated the use of antioxidants for the prevention and treatment of cardiovascular diseases and neurodegenerative disorders.
The determination of lipid peroxidation (MDA) and enzymes, such as catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPO), and butyrylcholinesterase (BuChe), can provide information on the degree of oxidative stress. Furthermore, cytokines’ and prostaglandins’ monitoring provides a measure of the inflammatory state.
The molecular evaluation of inflammatory oxidative stress may represent a useful biochemical approach for comparing different drug administrations for various pathologies. Therefore, this Special Issue encourages manuscript submissions on oxidative stress, its biochemical pathways, and potential interventions to mitigate its harmful effects.
Dr. Giuseppe Bruschetta
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aging
- antioxidant mechanisms
- cancer
- cytokines
- enzymatic pathways
- inflammatory processes
- oxidative stress
- reactive oxygen species (ROS)
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
