Oxidative Stress and Disease: Basic and Biochemical Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 25 November 2025 | Viewed by 22
Special Issue Editor
Interests: biochemistry; veterinary medicine; molecular biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pollution, smoking, excessive alcohol consumption, and stress (external factors), in addition to metabolic processes in cells, such as respiration and digestion, produce many reactive oxygen species (ROS) and nitrogen species every day. These unstable molecules cause oxidative stress, an imbalance between ROS and nitrogen species in the cell, and affect its ability to neutralize them. Oxidative stress has detrimental effects, such as the onset of inflammatory processes and/or causing damage to cellular proteins, lipids, and nucleic acids. These negative effects must be counteracted by antioxidant biochemical pathways.
Moreover, oxidative stress is implicated in the development of diseases, including cancer, and many studies have investigated the use of antioxidants for the prevention and treatment of cardiovascular diseases and neurodegenerative disorders.
The determination of lipid peroxidation (MDA) and enzymes, such as catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPO), and butyrylcholinesterase (BuChe), can provide information on the degree of oxidative stress. Furthermore, cytokines’ and prostaglandins’ monitoring provides a measure of the inflammatory state.
The molecular evaluation of inflammatory oxidative stress may represent a useful biochemical approach for comparing different drug administrations for various pathologies. Therefore, this Special Issue encourages manuscript submissions on oxidative stress, its biochemical pathways, and potential interventions to mitigate its harmful effects.
Dr. Giuseppe Bruschetta
Guest Editor
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Keywords
- aging
- antioxidant mechanisms
- cancer
- cytokines
- enzymatic pathways
- inflammatory processes
- oxidative stress
- reactive oxygen species (ROS)
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