Oxidative Stress and Disease: Basic and Biochemical Approaches

Dear Colleagues,

Pollution, smoking, excessive alcohol consumption, and stress (external factors), in addition to metabolic processes in cells, such as respiration and digestion, produce many reactive oxygen species (ROS) and nitrogen species every day. These unstable molecules cause oxidative stress, an imbalance between ROS and nitrogen species in the cell, and affect its ability to neutralize them. Oxidative stress has detrimental effects, such as the onset of inflammatory processes and/or causing damage to cellular proteins, lipids, and nucleic acids. These negative effects must be counteracted by antioxidant biochemical pathways.

Moreover, oxidative stress is implicated in the development of diseases, including cancer, and many studies have investigated the use of antioxidants for the prevention and treatment of cardiovascular diseases and neurodegenerative disorders.

The determination of lipid peroxidation (MDA) and enzymes, such as catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPO), and butyrylcholinesterase (BuChe), can provide information on the degree of oxidative stress. Furthermore, cytokines’ and prostaglandins’ monitoring provides a measure of the inflammatory state.

The molecular evaluation of inflammatory oxidative stress may represent a useful biochemical approach for comparing different drug administrations for various pathologies. Therefore, this Special Issue encourages manuscript submissions on oxidative stress, its biochemical pathways, and potential interventions to mitigate its harmful effects.

Dr. Giuseppe Bruschetta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.