Regulation of Brown Adipose Function
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 32
Special Issue Editors
Interests: cardiovascular biology; cardiovascular diseases and their risk factors; brown adipose tissue; healthful aging
Special Issue Information
Dear Colleagues,
Brown adipose tissue (BAT) is a thermogenic organ specialized in dissipating energy through uncoupled respiration to produce heat. In addition to this classical role, recent studies have revealed that BAT also functions as an endocrine organ, releasing signaling molecules that mediate crosstalk with other metabolically active tissues, such as the liver, skeletal muscle, and heart. These interactions have been identified in both human and animal studies, which report significant correlations between BAT activity and systemic metabolic regulation. Emerging therapeutic strategies targeting BAT—particularly those focusing on its secreted factors, functional heterogeneity, and regulatory mechanisms—offer promising avenues for advancing our understanding of adipose tissue biology and for developing novel interventions for metabolic disorders. This Special Issue of the International Journal of Molecular Sciences, titled “Regulation of Brown Adipose Function,” invites original research articles and comprehensive reviews that provide novel insights into the molecular mechanisms, physiological roles, and therapeutic potential of BAT. Articles on comparisons of BAT with white adipose tissue and the beiging of white adipose tissue are also invited. Additional topics include the role of BAT in mediating healthful longevity, enhancing exercise performance, and protecting against obesity and diabetes, hypothermia, myocardial ischemia, heart failure, angiogenesis, hypertension, and cancer. Submissions involving the use of cellular systems, animal models, or human subjects, including clinical studies, are all welcome.
Prof. Dr. Stephen F. Vatner
Dr. Shinsuke Nirengi
Guest Editors
Manuscript Submission Information
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Keywords
- brown adipose tissue
- metabolic disorders
- thermogenesis
- endocrine function
- cellular signaling
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