Cellular Memory in Response to Environmental Conditions

Dear Colleagues,

In nature, living organisms possess the plasticity to alter their developmental trajectory in response to environmental conditions for survival. Among various environmental factors, nutritional status is one of the most impactful, as exemplified by the concept of the Developmental Origins of Health and Disease (DOHaD) in mammals. Increasing evidence has shown that such alterations can be transmitted to the next generation through germ cells, suggesting that single cells can retain a 'memory' of environmental experiences. However, our understanding of how cells ‘remember’ their environment, often by reprogramming their metabolism even after the environmental stimulus has ceased, remains limited.

We are pleased to invite you to contribute to advancing the understanding of the underlying mechanisms, helping to pave the way for discoveries in this exciting field.

This Special Issue aims to uncover new molecular mechanisms underlying cellular memory in response to environmental conditions in mammals. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following topics explored through either in vivo or in vitro studies:

1. Advances in understanding cellular memory, including that of germ cells, in response to environmental conditions.
2. Advances in understanding the relationship between cellular and organ (or tissue) memory in response to environmental conditions.
3. Advances in understanding the relationship between cellular memory and disease in response to environmental conditions.
4. Advances in understanding the robustness or resilience of cellular memory in response to environmental conditions.
5. Sex-specific differences in cellular memory in response to environmental cues.

Prof. Dr. Satoshi Kishigami
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.