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Molecular Research and Application of Platelet-Rich Plasma

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 1474

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Guest Editor
Grupo de Investigación Terapia Regenerativa, Departamento de Salud Animal, Universidad de Caldas, Manizales, Colombia
Interests: regenerative medicine; biomechanics; fracture; sports injuries; trauma surgery
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Special Issue Information

Dear Colleagues,

Platelet-rich plasma (PRP) has gained significant attention in regenerative medicine due to its high concentration of growth factors, cytokines, and other bioactive molecules that support tissue repair and modulate inflammation. In addition to its molecular components, PRP functions as a natural fibrin scaffold that facilitates cell adhesion, migration, and differentiation—key processes in tissue regeneration. Advances in molecular research have provided deeper insights into the mechanisms through which PRP exerts its effects, including modulation of gene expression, cellular signaling, and immune responses. This Special Issue aims to gather high-quality contributions exploring all aspects of PRP, from its molecular characterization and standardization to its application in both preclinical and clinical settings. Original research, comprehensive reviews, and translational studies—including those involving animal models—are welcome. Our goal is to provide a broad and rigorous overview of current knowledge and innovations in PRP-based therapies.

Prof. Dr. Jorge U. Carmona
Guest Editor

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Keywords

  • platelet-rich plasma
  • fibrin scaffold
  • regenerative medicine
  • molecular biology
  • translational medicine

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Published Papers (1 paper)

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Review

23 pages, 1695 KB  
Review
Molecular and Regenerative Effects of Platelet-Rich Plasma and Related Hemocomponents in Animal Models of Liver Injury—A Systematic Review
by Jorge U. Carmona, Julián David Hernández-Valencia and Catalina López
Int. J. Mol. Sci. 2026, 27(2), 1013; https://doi.org/10.3390/ijms27021013 - 20 Jan 2026
Viewed by 1170
Abstract
Platelet-rich plasma (PRP) has been increasingly explored as a biologic strategy for liver repair; however, preclinical studies have evaluated not only intact PRP but also PRP related hemocomponents with distinct biological properties, complicating interpretation and translation of the evidence. A systematic review of [...] Read more.
Platelet-rich plasma (PRP) has been increasingly explored as a biologic strategy for liver repair; however, preclinical studies have evaluated not only intact PRP but also PRP related hemocomponents with distinct biological properties, complicating interpretation and translation of the evidence. A systematic review of experimental studies was conducted to assess the effects of PRP and related hemocomponents in animal models of liver injury, focusing on molecular, metabolic, biochemical, and histological outcomes, and evaluating methodological quality and risk of bias using the Cochrane ROB 2.0 framework. Fourteen eligible studies were identified across toxic, cholestatic, parasitic, radiation-induced, and surgical models. Platelet-based interventions were generally associated with hepatoprotective, antifibrotic, antioxidant, immunomodulatory, and pro-regenerative effects; however, responses were highly context dependent and varied according to injury etiology, disease stage, administration route and timing, and the frequent use of combination therapies. Substantial heterogeneity in the platelet-based products evaluated—including platelet supernatants and lysates—and inconsistent reporting of key compositional parameters limited product classification, cross-study comparability, and mechanistic interpretation, while ROB 2.0 assessments revealed predominantly some concerns of bias. PRP and related hemocomponents show biologically relevant effects in experimental liver injury, but their translational potential is constrained by methodological heterogeneity and inadequate product characterization. Standardized reporting, controlled comparative designs, and clinically relevant models are required to clarify efficacy and support rational translation. Full article
(This article belongs to the Special Issue Molecular Research and Application of Platelet-Rich Plasma)
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