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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic and Epigenetic Analyses in Cancer

edited by Jing Gong

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1153 | Submission Open

Keywords: epigenetics; genetic mutations; chromosomal instability; DNA methylation; histone modifications; non-coding rnas; multi-omics; transcriptomics; proteomics; drug resistance in cancer; cancer biomarkers; therapeutic targets in cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights in Antivirals and Vaccines

edited by

Gergana Zahmanova

Ivan Minkov

and

Yoana Dimitrova Kiselova-Kaneva

submission deadline 20 Nov 2025 | Viewed by 1148 | Submission Open

Keywords: new vaccine platforms; cell cultures; plant molecular farming; vaccines and VLPs; nanoparticle vaccines; emerging viral diseases; novel therapeutics; biologics; antibodies; receptor modulators; plant-based compounds with antiviral activity; medicinal plant-derived products; bioactive proteins from plants

(This special issue belongs to the Section Molecular Microbiology)

Computational Design and Therapeutic Applications of Peptide-Based Drugs

edited by

Shayon Bhattacharya

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1143 | Submission Open

Keywords: peptide drug design; in silico drug discovery; peptide– protein interactions; therapeutic peptides

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Animal Reproduction

edited by

Zhongliang Jiang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1026 | Submission Open

Keywords: spermatogenesis; follicular atresia; oocyte maturation; granulosa cells; hormone regulation; autophagy; apoptosis; miRNA; signaling regulation

(This special issue belongs to the Section Molecular Biology)

Pharmacology and Toxicology of Synthetic and Natural Products

edited by

Sherif T.S. Hassan

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1022 | Submission Open

Keywords: pharmacology and toxicology; pharmacodynamics and pharmacokinetics; synthetic drugs; natural products; drug interactions; molecular mechanisms; therapeutic potential; adverse effects; dose– response relationship; drug safety and efficacy

(This special issue belongs to the Section Molecular Pharmacology)

Novel Insights into Bone Tissue: Pathologies and Therapeutic Strategies

edited by

Francesca Salamanna

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1019 | Submission Open

Keywords: bone tissue; pathologies; regenerative medicine; biomechanics; diagnostics; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Application of Machine Learning to Molecular Dynamics Simulations

edited by

Isabella Romeo

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1017 | Submission Open

Keywords: molecular dynamics simulations; machine learning; AI in drug discovery; pharmacokinetics prediction; protein folding simulations; toxicity prediction using ML; free energy calculations; virtual screening; protein– ligand interactions; protein– protein interactions

(This special issue belongs to the Section Molecular Informatics)

Research on Intracellular Signal Transduction Systems

edited by

Takaya Satoh

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1001 | Submission Open

Keywords: signal transduction; receptor; G protein; kinase; second messenger; gene expression; cytoskeleton; human disease

(This special issue belongs to the Section Molecular Biology)

Therapeutic Potential of Antioxidants in the Prevention of Human Diseases, 2nd Edition

edited by

Kota V. Ramana

submission deadline 20 Nov 2025 | 1 articles | Viewed by 990 | Submission Open

Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Plant Cell Biology

edited by

Jacek Z. Kubiak

and

Malgorzata Kloc

submission deadline 20 Nov 2025 | 1 articles | Viewed by 974 | Submission Open

Keywords: chloroplasts; cell wall; vacuoles; microtubule cytoskeleton; plant-cell-specific structures

(This special issue belongs to the Section Molecular Plant Sciences)

Composites of Carbon Nanomaterials and Transition Metals: Preparation, Properties, Bioapplications

edited by

Robert Piech

submission deadline 20 Nov 2025 | 1 articles | Viewed by 947 | Submission Open

Keywords: composite materials; carbon nanomaterials; nanoparticles of transition metals and their compounds; preparation and functionalization of composite materials; biosensors; bioapplications

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research on Pathogenesis and Treatment of Pregnancy Complications

edited by

Melissa Wilson

submission deadline 20 Nov 2025 | 1 articles | Viewed by 903 | Submission Open

Keywords: hypertensive disorders of pregnancy; preeclampsia; molecular biology; biomarker; prevention; therapeutics; placenta

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and New Markers of Cancer

edited by

Antonio D’Amati

submission deadline 20 Nov 2025 | 1 articles | Viewed by 902 | Submission Open

Keywords: molecular pathology; molecular mechanisms; immunotherapy; cancer; oncology; pathology; biomarkers

(This special issue belongs to the Section Molecular Oncology)

DNA Replication, Damage and Repair in Repeat Instability: Their Role from Bacteria to Genetic Disorders in Humans

edited by

Enrique Viguera

submission deadline 20 Nov 2025 | 1 articles | Viewed by 864 | Submission Open

Keywords: DNA repeat instability; DNA replication; DNA damage; DNA repair; tandem repeats; trinucleotide repeats; repeat expansion diseases; microsatellite instability; replication slippage; phenotypic variability; bacteria; genetic disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights into Antifungal Resistance and Virulence

edited by

Francisco E. Nicolás

submission deadline 20 Nov 2025 | 1 articles | Viewed by 832 | Submission Open

Keywords: fungal infections; antifungal therapies; antifungal resistance; fungal virulence

(This special issue belongs to the Section Molecular Microbiology)

Advances of Organic Synthesis in Drug Discovery

edited by

Laura Gabriela Sârbu

submission deadline 20 Nov 2025 | 2 articles | Viewed by 796 | Submission Open

Keywords: organic synthesis; drug design; heterocyclic chemistry; functionalization

(This special issue belongs to the Section Molecular Pharmacology)

MicroRNA (miRNA) Technology in Cancer

edited by

Duncan Ayers

submission deadline 20 Nov 2025 | 1 articles | Viewed by 761 | Submission Open

Keywords: miRNA; microRNA; cancer; oncology; drug delivery; technology; non-coding RNA

(This special issue belongs to the Section Molecular Oncology)

Whole-Cell System and Synthetic Biology, 2nd Edition

edited by

Jingjing Tian

submission deadline 20 Nov 2025 | 1 articles | Viewed by 760 | Submission Open

Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling Apoptosis: Deciphering Molecular Mechanisms

edited by

Gabriella Simbula

submission deadline 20 Nov 2025 | Viewed by 752 | Submission Open

Keywords: apoptosis; development; microenvironment; mitochondria dysfunction; molecular mechanisms; tumors; degenerative diseases; diabetes; metabolic diseases; neurodegenerative disease; novel pharmacological strategies

(This special issue belongs to the Section Biochemistry)

Aquatic Organisms Models Dedicated to Disease

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 Nov 2025 | Viewed by 723 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Physiological Analysis of Stress in Plants

edited by

Yong Li

submission deadline 20 Nov 2025 | 1 articles | Viewed by 703 | Submission Open

Keywords: plant stress; biotic stress; abiotic stress; stress response; gene expression; epigenetic stress memory; ABA; SA

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Precision Medicine During Surgery and Postoperative Care

edited by Lukas Andereggen and Markus M. Luedi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 697 | Submission Open

Keywords: genomics & pharmacogenomics; molecular mechanisms of anesthesia; perioperative biomarkers; perioperative care; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Precision Medicine in Cancers

edited by

Mehdi Kardoust Parizi

submission deadline 20 Nov 2025 | Viewed by 687 | Submission Open

Keywords: precision medicine; cancer biomarkers; targeted therapy; genomic profiling; personalized treatment; tumor heterogeneity; molecular diagnostics; clinical research

(This special issue belongs to the Section Molecular Oncology)

Genetic Testing in Molecular Pathology and Diagnosis

edited by

Marco Fabiani

submission deadline 20 Nov 2025 | 1 articles | Viewed by 661 | Submission Open

Keywords: genetic testing; molecular pathology; personalized medicine; genetic diagnostics; disease mechanisms; novel genetic tests; clinical integration; patient management

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 20 Nov 2025 | 1 articles | Viewed by 659 | Submission Open

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Orchid Plants: 2nd Edition

edited by Wen‑Chieh Tsai

submission deadline 20 Nov 2025 | 1 articles | Viewed by 577 | Submission Open

Keywords: orchid; genomics; genome; genes; tumor; inflammation; drug; transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Fruit Tree Physiology, Breeding and Genetic Research

edited by Jiangping Mao

submission deadline 20 Nov 2025 | 1 articles | Viewed by 568 | Submission Open

Keywords: fruit tree; genetic breeding; fruit tree physiology; gene functional identification

(This special issue belongs to the Section Molecular Plant Sciences)

Endothelial Dysfunction, Inflammation and Cognition

edited by Christelle Basset and Anne S. Prigent-Tessier

submission deadline 20 Nov 2025 | Viewed by 553 | Submission Open

Keywords: inflammation; endothelial dysfunction; cognition; nitric oxide (NO); BDNF; physical exercise

(This special issue belongs to the Section Molecular Biology)

Therapeutics and Pathophysiology of Cognitive Dysfunction

edited by

Maheedhar Kodali

submission deadline 20 Nov 2025 | 1 articles | Viewed by 522 | Submission Open

Keywords: cognition; neurologic diseases; neuroinflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Biology on Mycobacteria: 2nd Edition

edited by

Rita Macedo

submission deadline 20 Nov 2025 | 1 articles | Viewed by 517 | Submission Open

Keywords: genus Mycobacterium; non-tuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium leprae; molecular diagnosis; molecular surveillance methodologies; molecular resistance prediction

(This special issue belongs to the Section Molecular Microbiology)

Nucleolus, Nucleolar Stress, and Ribosome Biogenesis in the Nervous System

edited by

Theologos Michaelidis

submission deadline 20 Nov 2025 | Viewed by 478 | Submission Open

Keywords: nucleolus; nucleolar stress; nucleolar homeostasis; polymerase I; rDNA transcription; ribosome biogenesis; translation; ribosomopathies; apoptosis; autophagy; senescence; neurodegeneration; tumorigenesis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights and Innovations in Brain Cancer Research

edited by Vinay K. Sharma

submission deadline 20 Nov 2025 | 1 articles | Viewed by 476 | Submission Open

Keywords: glioblastomas; astrocytomas; brain tumors; targeted therapies; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition

edited by

Lam-Son Phan Tran

and Mohammad G. Mostofa

submission deadline 20 Nov 2025 | 1 articles | Viewed by 474 | Submission Open

Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization

(This special issue belongs to the Section Molecular Plant Sciences)

Diabetes: Genetics and Genomics, Hormone Regulation, and Metabolic Control

edited by Maria Stathopoulou

submission deadline 20 Nov 2025 | Viewed by 468 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; monogenic diabetes; polygenic risk factors; gestational diabetes (GDM); maturity-onset diabetes of the young (MODY); latent autoimmune diabetes in adults (LADAs); genome-wide association studies (GWASs); single nucleotide polymorphisms (SNPs); epigenetic modifications in diabetes; insulin production regulation; hormone action and metabolic control; β -cell dysfunction; gene-environment interactions in diabetes; precision medicine in diabetes treatment; genetics; genomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thermodynamic and Spectral Studies of Complexes

edited by Michał Zabiszak

submission deadline 20 Nov 2025 | 1 articles | Viewed by 447 | Submission Open

Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Crosstalk Between Bone and Inflammation

edited by Jessica Cottrell

submission deadline 20 Nov 2025 | Viewed by 428 | Submission Open

Keywords: bone; inflammation; immunology; bone metabolism; inflammatory disease

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Emerging Therapies in Neurovascular Disease

edited by Leonidas D. Panos

submission deadline 20 Nov 2025 | 1 articles | Viewed by 417 | Submission Open

Keywords: neurovascular diseases; blood– brain barrier; endothelial dysfunction; cellular signaling; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Anticancer, Antioxidant, and Anti-Inflammatory Properties of Natural Products

edited by

Rita Carneiro Alves

, Nelson Andrade and Cláudia Silva

submission deadline 20 Nov 2025 | 1 articles | Viewed by 410 | Submission Open

Keywords: bioactive compounds; natural extracts; health promotion/disease prevention; oxidative stress modulation; inflammatory pathway regulation; anticancer and antitumoral effects; cellular mechanisms; in vitro and in vivo bioactivity studies

(This special issue belongs to the Section Molecular Pharmacology)

Bile Acids and Bile Acid Modifications in Health and Disease

edited by

Francisco J. Osuna-Prieto

submission deadline 20 Nov 2025 | Viewed by 398 | Submission Open

Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders

(This special issue belongs to the Section Molecular Microbiology)

Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments

edited by

Amit Roy

and

Amrita Chakraborty

submission deadline 20 Nov 2025 | Viewed by 396 | Submission Open

Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms

(This special issue belongs to the Section Molecular Biology)

Genetic Testing and Tailored Treatment for Thyroid Disorders: Molecular Basis and New Trends

edited by

Kyoung Sik Park

submission deadline 20 Nov 2025 | Viewed by 388 | Submission Open

Keywords: thyroid diseases; genetics; personalized medicine; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 383 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

New Insights in Artificial Intelligence for Drug Design and Target Discovery

edited by

Yanjing Wang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 363 | Submission Open

Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular, Translational and Clinical Research of Cancer Structural Biomarkers

edited by

Sabine Mai

submission deadline 20 Nov 2025 | Viewed by 359 | Submission Open

Keywords: structural biomarker; extracellular matrix; nuclear organization; discovery research; translational research; clinical research; cancer staging and prognosis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

ABC Transporters: Where Are We 45 Years On? (2nd Edition)

edited by

Anthony M George

submission deadline 20 Nov 2025 | 1 articles | Viewed by 359 | Submission Open

Keywords: nucleotide-binding cassette; transmembrane binding domain; drug resistance; X-ray and cryo-EM structures; molecular dynamics simulations; ABC transporter

(This special issue belongs to the Section Biochemistry)

New Advances of Free-Radical Reactions in Organic Chemistry

edited by

José Justicia

submission deadline 20 Nov 2025 | Viewed by 342 | Submission Open

Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Chemical and Biotechnological Strategies to Tailor the Properties of Biomaterials

edited by

Eduardo García-Junceda

and

Julia Revuelta

submission deadline 20 Nov 2025 | Viewed by 324 | Submission Open

Keywords: biomaterial functionalization; green chemistry in biomaterials; biotechnological modification; stimuli-responsive materials; translational biomaterials

(This special issue belongs to the Section Materials Science)

Role of Extracellular Vesicles in Diseases

edited by

Gorjana Rackov

and

Aoife Ward Gahlawat

submission deadline 20 Nov 2025 | Viewed by 324 | Submission Open

Keywords: extracellular vesicles (EVs); biomarkers; disease pathophysiology; miRNAs; intercellular communication; therapeutic targets; mitochondrial transfer; cancer; neurodegenerative disorders; precision medicine

(This special issue belongs to the Section Biochemistry)

Synthesis and Application of Chiral Ligands and Heterocycles in Pharmacological Studies

edited by

István Szatmári

submission deadline 20 Nov 2025 | Viewed by 322 | Submission Open

Keywords: nonracemic amino acids; enantioselective synthesis; chiral catalysis; enantiopure bioconjugates; electron-rich hydroxyquinoline; indole; β -carboline; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Cancer Models: Development and Applications

edited by

Yong Teng

submission deadline 20 Nov 2025 | Viewed by 315 | Submission Open

Keywords: tumor organoids; animal models of cancer; drug screening models; highly clinically relevant cancer models; technologies related to cancer model development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3151-3200 on page 64 of 69.

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