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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathogenesis of Central Nervous System Disorders, Interplay and Multifaceted Role of Glial Cells and Neuroprotective Mechanisms

edited by Matilde Balbi

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: neurodegenerative disease; CNS disorders; glial cells; glia-cross talk; extracellular vesicles; calcium pathway; neuroinflammation; autophagy; excitotoxicity; glial phenotype

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Phenolic Profiles and Anti-Inflammatory Activities of Plants

edited by Chi-Rei Wu and Li-Wei Lin

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: plants; phenolic profiles; inflammation; cardiovascular disorders; cancer; diabetes; neurodegenerative disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Endocrine–Immune Crosstalk in Human Reproductive Health and Pathology

edited by Juan Pablo Mackern-Oberti

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: T cells; B cells; autoimmune disease; reproduction; immunemodulation; inflammation; endocrinology; lactation

(This special issue belongs to the Section Molecular Immunology)

Next Generation Sequencing in Human Diseases

edited by

Manuel Muro

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: NGS; single-cell analysis; metagenomics; forensic DNA analysis; precision medicine; genetic diagnostics; transplant monitoring; cell-free DNA; new allele and variant discovery

(This special issue belongs to the Section Molecular Informatics)

Novel Biochemical, Genetic, and Molecular Biology Approaches in Human Reproduction

edited by Athanasios Zikopoulos

submission deadline 31 Dec 2025 | Viewed by 11 | Submission Open

Keywords: reproductive biology; infertilit; epigenetics in reproduction; maternal-fetal health; precision medicine

(This special issue belongs to the Section Molecular Biology)

Advances in Stem Cell Biology and Translational Medicine

edited by Yangluowa Qu

submission deadline 31 Dec 2025 | Viewed by 10 | Submission Open

Keywords: stem cell regulation; differentiation; proliferation; self-renewal; stem cell-based therapy; tissue engineering; translational research

(This special issue belongs to the Section Molecular Biology)

Gene Regulation and Neurotoxicity in Alcohol Related Pathologies

edited by

Stefano Casalotti

submission deadline 31 Dec 2025 | Viewed by 10 | Submission Open

Keywords: alcohol; ethanol; gene expression; neurotoxicity; epigenetics; polymorphisms; neu-rons; glial cell; plasticity

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Updates and Advances in "Materials Science" Section

edited by

Miklós Fried

submission deadline 31 Dec 2025 | Viewed by 10 | Submission Open

Keywords: nanomaterials; functional polymers; bio-inspired systems; complex intelligent; responsive materials

(This special issue belongs to the Section Materials Science)

Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers

edited by

Alessandro Mannucci

submission deadline 31 Dec 2025 | Viewed by 9 | Submission Open

Keywords: gastrointestinal cancers; liquid biopsy; circulating biomarkers; minimal residual disease; early cancer detection; tumor-agnostic assays; molecular diagnostics; precision oncology; predictive biomarkers; translational research

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Nanomaterials for Cancer Treatment and Translational Medicine

edited by

Mingzhen Zhang

submission deadline 31 Dec 2025 | Viewed by 9 | Submission Open

Keywords: nanozymes; extracellular vesicles; drug delivery systems; cancer treatment; oxidative stress-related diseases; translational medicine

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Molecular Research and Therapeutic Strategies for Endometrial Cancer

edited by

Yung-Taek Ouh

submission deadline 31 Dec 2025 | Viewed by 9 | Submission Open

Keywords: endometrial cancer; molecular classification; biomarkers; precision medicine; targeted therapy; immunotherapy; early detection; non-invasive diagnostics; genomic profiling; translational research

(This special issue belongs to the Section Molecular Oncology)

Advanced Researches of Plant-Pathogen Interaction

edited by

Hyong Woo Choi

submission deadline 31 Dec 2025 | Viewed by 8 | Submission Open

Keywords: molecular plant-pathogen interactions; pathogen detection; secondary metabolism; multi-omics approaches; antibiotic resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Recombinant Proteins and Antibody Engineering for Diagnostic and Treatment of Emerging Infectious Diseases

edited by

Gustavo Helguera

submission deadline 31 Dec 2025 | Viewed by 8 | Submission Open

Keywords: recombinant proteins; antibody engineering; monoclonal antibodies; hemorrhagic fevers; tuberculosis; emerging infectious diseases; neglected viruses; diagnostics; therapeutic antibodies

(This special issue belongs to the Section Molecular Immunology)

Molecular Research and Advances in Ocular Disease

edited by Da-Wen Lu

submission deadline 31 Dec 2025 | Viewed by 8 | Submission Open

Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genome Editing and Biotechnology in Fruit Improvement

edited by Hongxia Miao

submission deadline 31 Dec 2025 | Viewed by 7 | Submission Open

Keywords: fruit improvement; horticultural crops; genome editing; biotechnology; molecular biology; plant genetics

(This special issue belongs to the Section Molecular Plant Sciences)

25th Anniversary of IJMS: Updates and Advances in Molecular Pharmacology

edited by

Roberto Scatena

submission deadline 31 Dec 2025 | Viewed by 7 | Submission Open

Keywords: precision medicine; pharmacogenomics; targeted protein degradation (TPD); molecular pharmacology; RNA Therapeutics; novel drug modalities; proteomics; transcriptomics; personalized drug therapy

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Adaptive Mechanisms in Forest Genetics for a Sustainable Future

edited by

Gennaro Lettieri

submission deadline 31 Dec 2025 | Viewed by 6 | Submission Open

Keywords: forest genetics; breeding techniques; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Biology of Human Reproduction

edited by

Houda Amor

submission deadline 31 Dec 2025 | Viewed by 6 | Submission Open

Keywords: human reproduction; genomics; transcriptomics; proteomics; imaging technologies

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Underlying the Pathogenesis and Treatment of Gastrointestinal Disorders

edited by

Andrzej Pławski

submission deadline 31 Dec 2025 | Viewed by 5 | Submission Open

Keywords: gastrointestinal disorders; molecular mechanisms; diagnosis; treatment; precision medicine; biomarkers; gastrointestinal cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Systemic Lupus: Molecular Research, New Biomarkers and Novel Therapy

edited by Juan Pablo Mackern-Oberti

submission deadline 31 Dec 2025 | Viewed by 5 | Submission Open

Keywords: lupus; biomarkers; autoimmunity; inflammation; therapy; treatment; endocrine; prolactin; stress; T cell and B cell activation; T cell and B cell proliferation; antigenic immunosuppression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Supramolecular Liquid Crystal Compounds—From Molecular Design to Functional Materials

edited by

Katarzyna Merkel

submission deadline 31 Dec 2025 | Viewed by 4 | Submission Open

Keywords: supramolecular; self-assembled; liquid crystal; hydrogen bonding

(This special issue belongs to the Section Materials Science)

Innovative Approaches to RNA-Based Therapeutics

edited by

Elzbieta Kierzek

submission deadline 31 Dec 2025 | Viewed by 4 | Submission Open

Keywords: RNA therapeutic; RNA drug; antisense therapy; siRNA; delivery; oligonucleotides; mRNA vaccine

(This special issue belongs to the Section Molecular Biology)

Genetic Susceptibility in Human Diseases

edited by Xiaowu Gai

submission deadline 31 Dec 2025 | Viewed by 3 | Submission Open

Keywords: bioinformatics; genomics; genetic susceptibility to disease; genetic variation; gene– environment interactions; biomarkers; epigenetic mechanisms; pharmacogenomics; population genetics; bioinformatics tools and databases; novel diagnostics; targeted therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Synthetic Lethality Strikes: Outsmarting Cancer with Precision Medicine

edited by

Stefania Butini

submission deadline 31 Dec 2025 | Viewed by 3 | Submission Open

Keywords: synthetic lethality; precision medicine; DDR modulators; non-DDR modulators; cancer; BRCA; PARP; RAD51; RAD52

(This special issue belongs to the Section Molecular Oncology)

Oxidative–Inflammatory Crosstalk in Retinal Pigment Epithelium: Models, Mechanisms, and Modulators

edited by

Min-Yen Hsu

submission deadline 31 Dec 2025 | Viewed by 3 | Submission Open

Keywords: retinal pigment epithelium (RPE); oxidative stress; inflammation; immunometabolism; mitochondrial dysfunction; inflammasome; IL-8/VEGF signaling; heavy-metal toxicity; extracellular vesicles; antioxidant therapy

(This special issue belongs to the Section Molecular Immunology)

Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets

edited by Leonid Livshits

submission deadline 31 Dec 2025 | Submission Open

Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties

(This special issue belongs to the Section Molecular Biology)

Carbon Fiber, Carbon Nanofiber for Composites: Synthesis, Processing, Molecular Structure, Characterization, and Application

edited by Tridung Ngo

submission deadline 31 Dec 2025 | Submission Open

Keywords: carbon fiber; carbon nanofiber; nanotube; carbon fiber composites; synthesis; advanced manufacturing; characterization; recent advancements; applications

(This special issue belongs to the Section Materials Science)

Plant Responses to Microorganisms and Insects

edited by

Sumit Jangra

submission deadline 31 Dec 2025 | Submission Open

Keywords: biotic stresses; crop protection; signaling molecules; transcriptomics; proteomics; microRNAs; resistance mechanism; plant– microbe– vector interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Pharmacology for Neuropathic and Chronic Pain Management

edited by

Kuthati Yaswanth

and

Chih-Shung Wong

submission deadline 31 Dec 2025 | Submission Open

Keywords: neuropathic pain; diabetic neuropathy; chronic pain; DPP-4 inhibitors; SGLT2 inhibitors; pain pharmacology; neuroinflammation; glial activation; ion channels; cannabinoids; endogenous peptides; epigenetic modulation; extended-release formulations; drug repurposing; analgesic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Pathophysiology of Peripheral Neuropathies and Neuromuscular Disorders

edited by

Eleonora Galosi

submission deadline 31 Dec 2025 | Submission Open

Keywords: peripheral neuropathies; neuromuscular disorders; small fiber neuropathy; neuropathic pain; nerve regeneration; molecular pathways; next-generation sequencing

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Molecular Research on Chronic Heart Failure

edited by

Marco Tana

submission deadline 1 Jan 2026 | 2 articles | Viewed by 3716 | Submission Open

Keywords: chronic heart failure (CHF); cardiovascular medicine; cardiac amyloidosis; biomarkers; translational ap-proaches; molecular approaches; pharmacological treatment; molecular mechanisms; molecular pathways; prognosis; clinical practice in CHF management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Poly- and Oligo-Saccharides as Pharmaceutical Agents in Biology and Medicine

edited by

Kevin H. Mayo

submission deadline 1 Jan 2026 | Viewed by 102 | Submission Open

Keywords: polysaccharides; oligosaccharides; isolation and purification; structural and functional analyses; biological mechanisms of action; cellular & molecular targets and interactions; pharmaceutical drug development; cancer; cardiovascular disease; diabetes

(This special issue belongs to the Section Molecular Biology)

Molecular Signatures in Overt Neurodegenerative Disease: Toward Precision Diagnosis and Classification

edited by

Jose Miguel Laffita-Mesa

submission deadline 1 Jan 2026 | Viewed by 39 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; disease stratification; Parkinson’ s disease; Alzheimer’ s disease; spinocerebellar ataxia; precision medicine; digital PCR; circRNA; prognostic biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

From Microbes to Humans: Unveiling the Dynamic World of Carbonic Anhydrases (CAs)

edited by

Clemente Capasso

submission deadline 10 Jan 2026 | Viewed by 520 | Submission Open

Keywords: metalloenzymes; bacteria; pathogens; sulfonamides; inhibitors; activators; anti-infective agents; medicine; anticancer; neurodegenerative diseases; biomedical applications; biotechnology

(This special issue belongs to the Section Biochemistry)

Checkpoint Antibodies at the Crossroads: From Mechanisms to Multi-Modal Cancer Therapy

edited by Li Ye and Xuyao Zhang

submission deadline 10 Jan 2026 | Viewed by 67 | Submission Open

Keywords: immune checkpoint inhibitors; tumor microenvironment; computational immunology; resistance mechanisms; multifunctional antibodies; rational combination design

(This special issue belongs to the Section Molecular Immunology)

Advances in Allergen Immunotherapy: Current Concepts and Future Directions

edited by

Constantinos Pitsios

submission deadline 10 Jan 2026 | Viewed by 16 | Submission Open

Keywords: allergen immunotherapy; oral immunotherapy; Hymenoptera venom; allergy extracts; adjuvants

(This special issue belongs to the Section Molecular Immunology)

Natural-Derived Bioactive Compounds in Disease Treatment

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Jan 2026 | 5 articles | Viewed by 13719 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; nutraceuticals; anti-oxidants; gene expression; protein expression; cellular signaling; nanoformulations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insight into Plant Bioactive Compounds

edited by

Karolina Wojtunik-Kulesza

submission deadline 20 Jan 2026 | 4 articles | Viewed by 12667 | Submission Open

Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Structures and Biologic Activity of Marine Natural Products

edited by

Alexanra S. Silchenko

and

Vladimir Kalinin

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10208 | Submission Open

Keywords: marine natural products; secondary metabolites; structure elucidation; biologic activity; structure-activity relationships; taxonomic distribution; biosynthesis; functions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation

edited by

Masaru Tanaka

submission deadline 20 Jan 2026 | 3 articles | Viewed by 10109 | Submission Open

Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood– brain barrier; blood– cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment

edited by

Ilaria Mormile

submission deadline 20 Jan 2026 | 6 articles | Viewed by 9271 | Submission Open

Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation; molecular pathway; biomarkers; target therapy

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Pathophysiology and Immunology Related to SARS-CoV-2 Infection

edited by

Vito D’Agnano

submission deadline 20 Jan 2026 | 7 articles | Viewed by 8953 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunology; pathophysiology; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance

edited by

Marzena Kurowska

and

Boris Lazarević

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7984 | Submission Open

Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances of Novel Pharmaceutical Designs for Anti-Cancer Therapies, 3rd Edition

edited by

Bernhard Biersack

submission deadline 20 Jan 2026 | 6 articles | Viewed by 7425 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition

edited by

Balik Dzhambazov

submission deadline 20 Jan 2026 | 6 articles | Viewed by 7292 | Submission Open

Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms for Skin Protection and Aging

edited by Wonchul Lim and

Tae-Gyu Lim

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7139 | Submission Open

Keywords: skin photo-aging; skin inflammation; molecular biology; inner beauty; natural product; skin microbiome; skin wrinkle formation; skin dehydration; skin pigmentation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies

edited by

Renata Stawerska

submission deadline 20 Jan 2026 | 5 articles | Viewed by 6821 | Submission Open

Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions (2nd Edition)

edited by

Manuela Dicarlo

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6807 | Submission Open

Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Compounds in the Prevention of Chronic Diseases

edited by