Recent Advances in Genome-Edited Animal Models
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 8
Special Issue Editors
Interests: genome editing; genetic engineering; mouse genetics; embryo engineering; multiplex gene editing; functional genomics; reproductive biology; disease models; precision medicine
Interests: genetic engineering; manipulation of early embryos and germ cells; genome editing; in vivo gene delivery; non-integrating vector
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Special Issue Information
Dear Colleagues,
Recent advances in genome editing technologies such as CRISPR/Cas9, base editing, and prime editing have revolutionized our ability to engineer mammalian genomes with unprecedented precision. The combination of the existing transgenic approaches and the embryo manipulation further accelerated the generation of sophisticated animal models to study gene function, complex diseases, and developmental biology.
This Special Issue focuses on recent studies in multiplex gene editing, high-efficiency knock-in strategies, in vivo functional genomic screening, and model systems mimicking zygotic genome activation. In addition, we invite researchers worldwide to contribute to our efforts in exploring the applications of genome editing platforms in disease modeling, regenerative biology, and precision medicine.
Original research articles and comprehensive reviews that provide technical innovation, biological insight, or translational potential in these areas are highly encouraged. This collection aims to highlight the latest breakthroughs and challenges in this rapidly evolving field.
Dr. Takayuki Sakurai
Dr. Sato Masahiro
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- genome editing
- prime editing
- base editing
- CRISPRa/CRISPRi
- knock-in/out
- conditional genome editing
- multiplex genome editing
- manipulation of early embryos and germ cells
- in vivo gene delivery
- genome-edited animals
- disease animal model
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