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Endometriosis: Current Trends and Research Developments

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 223

Special Issue Editors


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Guest Editor
Department of Gynecology Charité with Center of Oncological Surgery, Endometriosis Research Center Charité, Berlin, Germany
Interests: molecular mechanisms of endometriosis pathogenesis; pain generation and neuromodulation; self‑management; mental health; patient‑centered care
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Guest Editor
Department of Gynecology Charité with Center of Oncological Surgery, Endometriosis Research Center Charité, Berlin, Germany
Interests: molecular mechanisms of endometriosis pathogenesis; pain generation and neuromodulation; analgesic targets; diagnostic tests

Special Issue Information

Dear Colleagues,

Endometriosis is a chronic, often debilitating, condition with a complex and multifactorial pathophysiology. Despite its high prevalence, the underlying molecular mechanisms remain insufficiently understood, limiting effective diagnostics and treatment. This Special Issue will bring together cutting-edge research elucidating the pathomechanisms of endometriosis through integrative, interdisciplinary approaches to molecular science. We welcome studies exploring hormonal regulation, immune modulation, genetic and epigenetic alterations, environmental factors, cell signaling, and tissue remodeling relevant to endometriosis.

Given the scope of IJMS, purely clinical studies are not suitable for this Special Issue. However, submissions based on patient cohorts, clinical samples, or in vitro/in vivo models are encouraged, provided that they include robust biomolecular experimentation, such as transcriptomic, proteomic, or metabolomic analyses; molecular pathway interrogation; or functional genomics.

This Special Issue will promote innovative biomolecular insights to inform future diagnostics, therapeutic strategies, and personalized medicine approaches in endometriosis research.

Prof. Dr. Sylvia Mechsner
Dr. Renata Voltolini Velho
Guest Editors

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Keywords

  • endometriosis
  • molecular mechanisms
  • pathophysiology
  • hormonal regulation
  • immune response
  • epigenetics
  • inflammation
  • biomarkers
  • transcriptomics
  • therapeutic targets

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Published Papers (1 paper)

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Research

19 pages, 1099 KB  
Article
The Histamine-Associated Inflammatory Landscape of Endometriosis: Molecular Profiling of HDC, HRH1-HRH4, and Cytokines Across Lesion Subtypes
by Renata Voltolini Velho, Julia Hannah Freitag, Arie Maeve Brueckner, Laura Thalmeier, Jonathan Pohl and Sylvia Mechsner
Int. J. Mol. Sci. 2026, 27(1), 212; https://doi.org/10.3390/ijms27010212 - 24 Dec 2025
Abstract
Pain in endometriosis involves not only nociceptive but also neuropathic and neurogenic components, reflecting its complex nature. Histamine, a biogenic amine, has emerged as a critical mediator connecting inflammation and nerve sensitization. This study aimed to characterize histamine receptor (HRH1–HRH4) expression, localization, and [...] Read more.
Pain in endometriosis involves not only nociceptive but also neuropathic and neurogenic components, reflecting its complex nature. Histamine, a biogenic amine, has emerged as a critical mediator connecting inflammation and nerve sensitization. This study aimed to characterize histamine receptor (HRH1–HRH4) expression, localization, and related inflammatory mediators in peritoneal, deep infiltrating, and ovarian endometriosis. Gene expression datasets were analyzed, and immunofluorescence staining of endometriotic lesions was performed using immune and neuronal markers. Histamine and its metabolite methylhistamine were quantified in serum, peritoneal fluid, and urine samples. HDC expression was significantly elevated in all endometriotic lesions compared with controls (all p < 0.01), paralleling increased IL-6, COX-2, NGF, and NGFR levels (p < 0.0001). In contrast, HRH1–HRH4 transcript levels showed no significant differences between groups. Immunofluorescence demonstrated robust HRH1–HRH4 protein expression in epithelial, immune, and nerve fibers, with subtype-specific colocalization patterns. Serum histamine concentrations were significantly higher in endometriosis patients than controls (0.484 vs. 0.153 ng/mg protein; p = 0.0014), whereas peritoneal histamine and urinary methylhistamine showed no group differences. Overall, these findings highlight histamine signaling as a potentially important component of endometriosis pathophysiology and point toward new directions for mechanistic studies and therapeutic exploration. Full article
(This article belongs to the Special Issue Endometriosis: Current Trends and Research Developments)
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