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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research on Actinomycetes-Derived Natural Products

edited by Fong Tian Wong

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1563 | Submission Open

Keywords: actinomycetes; natural products; actinobacterial; genome mining; omics; secondary metabolites; genetic engineering; discovery; structural diversity

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Effects of Chemicals on Brain Health and Development

edited by

Noriyuki Koibuchi

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1558 | Submission Open

Keywords: brain development; environmental chemicals; prescribed medicines; addictive drugs; neuronal plasticity; behavior; learning and memory; neurogenesis; cell death (apoptosis and necrosis)

(This special issue belongs to the Section Molecular Neurobiology)

Latest Molecular Research on Polymer Coatings

edited by

Joanna Karasiewicz

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1553 | Submission Open

Keywords: synthesis of specialty compounds; specialty compounds in industrial treatment; amphiphilic compounds; wettability (including solids and biomaterials); antimicrobial activity; surface activity; superwetting; high hydrophobic/hydrophilic/olrophobic/olephilic properties; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.

(This special issue belongs to the Section Materials Science)

Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity

edited by Bourlaye Fofana and

Champa Wijekoon

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1550 | Submission Open

Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity

(This special issue belongs to the Section Molecular Plant Sciences)

Antiviral Mechanisms of Natural/Synthetic Compounds

edited by Cybele Carina García

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1546 | Submission Open

Keywords: antiviral mechanisms; natural compound; synthetic compound; druggable viral/host target; emerging virus; host– virus interaction; innate antiviral response; cell-intrinsic restriction factor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Lectins: Structural Diversity, Molecular Recognition and Emerging Applications

edited by

Patrícia Maria Guedes Paiva

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1539 | Submission Open

Keywords: lectins; structural diversity; molecular recognition; bioactivities; biomedical applications

(This special issue belongs to the Section Biochemistry)

Redox Physiology

edited by Mateusz Mołoń

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1422 | Submission Open

Keywords: redox physiology; reactive oxygen species (ROS); reactive nitrogen species (RNS); oxidative stress; oxidation; redox signaling

(This special issue belongs to the Section Molecular Biology)

Contemporary Perspective of Cardio-Kidney Metabolic Syndrome: From Prevention to Management

edited by Alberto Palazzuoli,

Francesco Fedele

and

Anna Mattioli

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1401 | Submission Open

Keywords: cardiovascular risk factors; metabolic syndrome; chronic kidney disease; heart failure; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Computer-Aided Drug Design

edited by

Cleber Melo-Filho

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1396 | Submission Open

Keywords: computer-aided drug design (CADD); quantitative structure-activity/property relationship (QSAR/QSPR); cheminformatics; virtual screening; data curation; in silico; molecular docking; machine learning; deep learning

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research in Acute Lung Injury

edited by

Emilia Lecuona

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1390 | Submission Open

Keywords: acute lung injury; ARDS; primary graft dysfunction; immune cells; neutrophils; pulmonary edema; alveolar epithelium; lung endothelium

(This special issue belongs to the Section Molecular Immunology)

Computational Cancer Genomics and Molecular Profile in Breast Cancer

edited by Daniel Guimarães Tiezzi and

Stefano Maria Pagnotta

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1374 | Submission Open

Keywords: breast cancer; computational biology; genomics; molecular biology

(This special issue belongs to the Section Molecular Informatics)

Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects

edited by

Angelo Montana

and

Fabrizio Lo Faro

submission deadline 20 Jun 2026 | Viewed by 1348 | Submission Open

Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Pharmacology)

Emerging Therapeutic Strategies and Immunometabolic Pathways in Cancer

edited by Medhi Wangpaichitr

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1344 | Submission Open

Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism

(This special issue belongs to the Section Molecular Immunology)

Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action

edited by

Tianfang Wang

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1328 | Submission Open

Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure– function relationships

(This special issue belongs to the Section Molecular Biology)

The Chitosan Biomaterials: Advances and Challenges, 3rd Edition

edited by

Lacramioara Popa

Mihaela Violeta Ghica

and Cristina Elena Dinu-Pirvu

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1299 | Submission Open

Keywords: chitosan; chitosan biomaterials; chitosan derivatives; drug delivery; wound healing; tissue regeneration; dentistry; smart biomaterials

(This special issue belongs to the Section Materials Science)

Toxicology Research: Understanding and Predicting Compound—Induced Toxicity

edited by

Georgios Pampalakis

and

Eleni Zingkou

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1293 | Submission Open

Keywords: molecular toxicology; emerging toxicology; drug-induced toxicity; organ toxicology; animal models; in silico toxicology; in vitro models; pesticides; industrial chemicals

(This special issue belongs to the Section Molecular Toxicology)

Novel Cell Signaling Targets and Mechanism for Effective Individualized Therapies

edited by Kazuyuki Matsushita

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1293 | Submission Open

Keywords: novel cell signaling targets; individualized therapies; addiction signal pathway; diagnosis and treatment; cancer; neurodegenerative diseases; cell development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Antioxidants—Sources, Characteristics, and Biological Activity

edited by

Maciej Spiegel

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1287 | Submission Open

Keywords: natural antioxidants; oxidative stress; reactive oxygen species; inflammation; free radicals; structure– activity relationship; nutraceuticals; synergistic effects; plant-derived compounds; drug discovery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Machine Learning in Disease Diagnosis and Treatment: 2nd Edition

edited by

Makrina Karaglani

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1284 | Submission Open

Keywords: machine learning; diagnosis; treatment; algorithm; predictive; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Methylation in Cancer: Progress and Challenges

edited by

Michael Eccles

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1280 | Submission Open

Keywords: DNA methylation; cancer; hypomethylation; hypermethylation; epigenetics; tumor onset; tumor progression; technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Breeding for Important Economic Traits in Livestock

edited by

Dawei Wei

and

Syed Haidar Abbas Raza

submission deadline 20 Jun 2026 | Viewed by 1231 | Submission Open

Keywords: molecular breeding; livestock genetics; economic traits; genomic selection; adipogenesis; feed efficiency; disease resistance; non-coding RNAs; multi-omics; genetic improvement

(This special issue belongs to the Section Molecular Biology)

Molecular Crosstalk in Stress-Induced Psychopathology

edited by Ilaria Demori and

Natalia V. Gulyaeva

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1231 | Submission Open

Keywords: Depression; Anxiety; Post-traumatic stress disorder; Early life stress; Microbiota– gut– brain axis; Blood– brain barrier; Neurotransmission; Neuroinflammation; Eating disorders; Addiction; Psychoneuroendocrineimmunology; Allostasis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Animal Reproduction and Development

edited by

Yu-Feng Wang

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1231 | Submission Open

Keywords: spermatogenesis; oogenesis; fertilization; embryogenesis; cell division; cell differentiation; stem cell; abnormal development; obesity; cancer

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications

edited by

Mohammad El Khatib

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1211 | Submission Open

Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling

(This special issue belongs to the Section Molecular Biology)

Machine Learning Approaches in Drug Molecule Design

edited by

Bing Niu

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1206 | Submission Open

Keywords: machine learning; drug design; deep learning; virtual screening; QSAR; molecular property prediction; de novo drug design; pharmacokinetics; computational chemistry; drug discovery

(This special issue belongs to the Section Molecular Informatics)

The Evolution, Genetics and Pathogenesis of Viruses, 2nd Edition

edited by

Marta Szabat

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1192 | Submission Open

Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Aging: How Can We Live Beyond 100 Years?

edited by

Shin Murakami

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1155 | Submission Open

Keywords: aging; biomarkers; centenarians; longevity interventions; stress resistance and metabolism; age-related diseases

(This special issue belongs to the Section Molecular Biology)

Advances in Targeted Therapy and Immunotherapy for Lung Cancer

edited by

Walid Shalata

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1143 | Submission Open

Keywords: lung cancer; small-cell lung cancer; non-small-cell lung cancer; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Developmental Origins of Kidney Disease: Renal Programming

edited by Hyung-Eun Yim

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1140 | Submission Open

Keywords: air pollution; chronic kidney disease; congenital anomalies of the kidneys and urinary tract; high-risk pregnancy; nephrogenesis; renal programming; renin angiotensin system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unveiling the Functional Microbiomes of the Ocean: From Genes to Ecosystem Services

edited by

Sergey Dobretsov

and

Daniel Rittschof

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1106 | Submission Open

Keywords: microbiome; symbiosis; community organization; functional diversity; communication; microbial functions; metagenomics; metabolomics; transcriptomics; proteomics; biogeochemical cycling; biofouling; ocean health; marine biotechnology; microbial ecology

(This special issue belongs to the Section Molecular Microbiology)

New Insights into Environmental Stresses and Plants: Second Edition

edited by

Zhou Li

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1092 | Submission Open

Keywords: abiotic stress; biotic stress; adaptation; gene function; omics; metabolic regulation; stress signal; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic Susceptibility in Human Diseases

edited by Xiaowu Gai

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1081 | Submission Open

Keywords: bioinformatics; genomics; genetic susceptibility to disease; genetic variation; gene– environment interactions; biomarkers; epigenetic mechanisms; pharmacogenomics; population genetics; bioinformatics tools and databases; novel diagnostics; targeted therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms and Therapies of Pancreatic Cancer: 3rd Edition

edited by

Donatella Delle Cave

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1015 | Submission Open

Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy

(This special issue belongs to the Section Molecular Oncology)

Advancing Research on Alexander Disease

edited by

Ming-Der Perng

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1010 | Submission Open

Keywords: Alexander disease; astrocyte dysfunction; intermediate filaments; GFAP; astrogliosis; neurodegeneration; leukodystrophy; rare disease; rosenthal fibers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Protein Folding and Misfolding

edited by

Ho-Jin Lee

submission deadline 20 Jun 2026 | Viewed by 984 | Submission Open

Keywords: protein folding; protein misfolding; 3D protein structure; CRISPR/Cas 9

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms of Parasitic Diseases

edited by Rajendranath Ramasawmy

submission deadline 20 Jun 2026 | 1 articles | Viewed by 982 | Submission Open

Keywords: parasites; molecular mechanisms; pathogenesis; genetics; symptomatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Crossroads in Cardiac Pathophysiology

edited by

Robert J. Chilton

submission deadline 20 Jun 2026 | 1 articles | Viewed by 979 | Submission Open

Keywords: cardiometabolic disease; cardiac metabolism; heart failure; mitochondrial dysfunction; insulin resistance; cardiometabolic therapies; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis, Modification, and Functional Characterization of Advanced Biomaterials for Bone Tissue Engineering

edited by

Elisa Boanini

submission deadline 20 Jun 2026 | 1 articles | Viewed by 949 | Submission Open

Keywords: material functionalization; bioactive materials; antimicrobial; antibiofilm; coatings; scaffolds; bone cements; metal nanoparticles; controlled release; biocompatibility

(This special issue belongs to the Section Materials Science)

Anti-Cancer Effects of Natural Products: 2nd Edition

edited by

Moon Nyeo Park

submission deadline 20 Jun 2026 | 1 articles | Viewed by 944 | Submission Open

Keywords: cancer; natural products; herbal medicine; anticancer therapies; metastasis; recurrence; resistance mechanism; novel biomarker

(This special issue belongs to the Section Molecular Pharmacology)

Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease

edited by Alessandra Porcu

submission deadline 20 Jun 2026 | 1 articles | Viewed by 941 | Submission Open

Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit

(This special issue belongs to the Section Molecular Neurobiology)

Endothelial Dysfunction, Inflammation and Cognition

edited by Christelle Basset and Anne S. Prigent-Tessier

submission deadline 20 Jun 2026 | Viewed by 913 | Submission Open

Keywords: inflammation; endothelial dysfunction; cognition; nitric oxide (NO); BDNF; physical exercise

(This special issue belongs to the Section Molecular Biology)

Exploring Recent Research on Natural Compounds: From Biosynthesis to Application

edited by

Nitin Mantri

submission deadline 20 Jun 2026 | Viewed by 895 | Submission Open

Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery

(This special issue belongs to the Section Biochemistry)

Advanced Research in Alzheimer’s Disease: From Pathology to Therapy

edited by Sofía Yolanda Díaz Miranda

submission deadline 20 Jun 2026 | 1 articles | Viewed by 885 | Submission Open

Keywords: multifunctional compounds in Alzheimer’ s disease therapy; translational medicine in Alzheimer's disease; novel drug candidates for Alzheimer's disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products: Pharmacological Insights and Advances

edited by

Jialuo Huang

submission deadline 20 Jun 2026 | 1 articles | Viewed by 880 | Submission Open

Keywords: natural products; biological activity; pharmacology; mechanism of action; molecular targets

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Dynamics Techniques in the Artificial Intelligence Era

edited by

Luciano Tavares Costa

Andrew S. Paluch

and Itamar Borges Junior

submission deadline 20 Jun 2026 | Viewed by 877 | Submission Open

Keywords: molecular dynamics; machine learning; force field; free energy; statistical mechanics; algorithm development; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

Development, Characterization and Applications of Novel Polymeric Materials and Composites: 2nd Edition

edited by

Daniel Dumitru Banciu

and

Xiao Hu

submission deadline 20 Jun 2026 | 1 articles | Viewed by 864 | Submission Open

Keywords: diagnosis; therapy; polymers; composite materials; theoretical model

(This special issue belongs to the Section Materials Science)

Metals in Human Diseases: From Molecular Mechanisms to Innovative Therapies

edited by

Jacek Baj

submission deadline 20 Jun 2026 | 1 articles | Viewed by 853 | Submission Open

Keywords: metallomics; trace elements; metal homeostasis; metal-induced toxicity; bioinorganic chemistry; chelation therapy; metal-based therapeutics; ICP-MS/LA-ICP-MS; neurodegeneration and metals; environmental metal exposure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Breast Cancer and Molecular-Based Treatments

edited by

Marcus Vetter

submission deadline 20 Jun 2026 | 1 articles | Viewed by 847 | Submission Open

Keywords: breast cancer; immunotherapy; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cutting-Edge Advances in Natural Bioactive Compounds

edited by

Joachim Storsberg

submission deadline 20 Jun 2026 | Viewed by 820 | Submission Open

Keywords: natural bioactive compounds; phytochemicals; fungal metabolites; antioxidant activity; anti-inflammatory agents; antimicrobial compounds; anti-cancer compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Detrimental and Beneficial Roles of Glial Cells After Neural Disorders

edited by

Walace Gomes-Leal

submission deadline 20 Jun 2026 | Viewed by 814 | Submission Open

Keywords: neuroprotection; neuroinflammation; cell therapy; microglia; astrocytes; oligodendrocytes; Janus face; double-edged sword

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 301-350 on page 7 of 63.

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