Sperm Physiology and Male Infertility: From Basic Biology to Molecular Genetics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 19
Special Issue Editors
Interests: Sperm Biology
Interests: oxidative stress; antioxidants; reproductive biology; fertilization; demography
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Male infertility affects millions of individuals worldwide and remains an under-recognized contributor to reproductive failure. This Special Issue invites original research, reviews, and perspectives that explore the complex biology of sperm function and the molecular and genetic underpinnings of male infertility.
We welcome submissions that cover a broad range of topics including, but not limited to, the following:
- Sperm development, maturation, and function.
- Cellular and molecular mechanisms regulating spermatogenesis.
- Sperm motility, capacitation, and acrosome reaction.
- Oxidative stress and sperm DNA damage.
- Epigenetics and transcriptomics in sperm biology.
- Genetic and genomic causes of male infertility.
- Emerging biomarkers and diagnostic tools.
- Functional assays and models for male fertility evaluation.
- Translational research and therapeutic strategies.
This Special Issue aims to bridge basic and clinical research, encouraging interdisciplinary approaches that advance our understanding of male reproductive health and inform better diagnostics and treatments.
Join us in advancing the field of andrology by contributing to this timely and impactful issue.
We look forward to receiving your contributions.
Dr. Mónica Vazquez-Levin
Prof. Dr. Robert John Aitken
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- human sperm
- fertilization
- infertility
- biomarkers
- genetics
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