Molecular Aspects of Tumor Radiotherapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 17
Special Issue Editor
Interests: radiotherapy; tumor microenvironment; DNA repair; cellular metabolism; cancer stem cells; hypoxia; radioresistance mechanisms; combination therapies; biomarkers; precision medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The molecular aspects of tumor radiotherapy represent a critical frontier in modern cancer research, where understanding the intricate molecular mechanisms underlying radiation response has become paramount for advancing personalized therapeutic strategies. Despite the role of radiotherapy in curing approximately 40% of cancers, treatment resistance remains a formidable clinical challenge, demanding deeper molecular insights to optimize therapeutic outcomes.
This Special Issue seeks to consolidate cutting-edge research that elucidates the molecular determinants of radiotherapy efficacy and resistance. We invite original research articles and comprehensive reviews that explore the complex interplay between cellular metabolism, DNA damage response pathways, and the tumor microenvironment in modulating radiation sensitivity. Key areas of interest include, but are not limited to, the role of cellular metabolism in radiotherapy sensitivity, the impact of DNA damage response and repair pathways, and the influence of hypoxia, immune cells, and stromal components within the tumor microenvironment.
We especially encourage submissions examining novel combination strategies that enhance radiotherapy efficacy through metabolic modulators, DNA repair inhibitors, and immunotherapeutic agents. Studies utilizing diverse experimental models, from in vitro cellular systems to patient-derived xenografts and clinical specimens, are particularly valued. Furthermore, research investigating predictive biomarkers for treatment response and innovative approaches to overcome resistance mechanisms, including targeting the tumor microenvironment and hypoxia-mediated resistance, will significantly contribute to this collection.
By fostering dialog between basic scientists and clinicians, this Special Issue aims to accelerate the translation of molecular discoveries into precision radiotherapy approaches that maximize tumor control while minimizing normal tissue toxicity.
Dr. Johann Matschke
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- radiotherapy resistance
- tumor microenvironment
- DNA damage response
- metabolic reprogramming
- combination therapies
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