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Molecular Signaling and Cellular Mechanisms in Asthma

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 413

Special Issue Editor


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Guest Editor
National Jewish Health, Denver, CO, USA
Interests: asthma; innate lymphoid cells; Th2 cells; endotypes

Special Issue Information

Dear Colleagues,

Asthma is a heterogeneous and complex immune inflammatory condition affected by several environmental and pathophysiological conditions. Due to the emergence of more complex and varied endotypes and phenotypes of asthma, there is an unmet need to study and understand the molecular mechanism involved in various endotypes of this allergic condition. In this Special Issue, we want to accommodate a wide variety of original research deciphering the molecular mechanism and cell types involved in various asthma endotypes as well as the review articles summarizing the progress made in this field in recent years.

This Special Issue is supervised by Dr. Kapil Sirohi and assisted by our GE Assistant, Dr. Anand Santosh Sripada (National Jewish Health, Denver, CO, USA).

Dr. Kapil Sirohi
Guest Editor

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Keywords

  • asthma
  • endotypes
  • pausi-immune asthma
  • nonatopic asthma
  • steroid insensitivity
  • neutrophilic asthma
  • innate lymphoid cells
  • Th2 cells

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Published Papers (1 paper)

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Research

19 pages, 788 KB  
Article
Analysis of Selected Serum Cytokines to Evaluate the Early Efficacy of Benralizumab, Dupilumab, and Mepolizumab in Severe Eosinophilic Asthma Treatment
by Aleksandra Niemiec-Górska, Łukasz Labus, Sylwia Mielcarska, Joanna Glück, Zenon Czuba, Marcin Cyrnek, Olga Branicka, Barbara Rymarczyk and Radosław Gawlik
Int. J. Mol. Sci. 2025, 26(20), 10075; https://doi.org/10.3390/ijms262010075 - 16 Oct 2025
Viewed by 189
Abstract
Background: Severe asthma is a chronic, difficult-to-treat disorder that significantly affects quality of life, and oral glucocorticosteroids are usually required. Many patients suffering from severe asthma exhibit T2 inflammation and may benefit from biological treatment. This study aims to evaluate changes in cytokine [...] Read more.
Background: Severe asthma is a chronic, difficult-to-treat disorder that significantly affects quality of life, and oral glucocorticosteroids are usually required. Many patients suffering from severe asthma exhibit T2 inflammation and may benefit from biological treatment. This study aims to evaluate changes in cytokine concentrations during therapy with benralizumab, dupilumab, and mepolizumab in severe eosinophilic asthma. Materials and Methods: In this prospective, single-center study, 39 patients with severe eosinophilic asthma received treatment with one of the above-mentioned biologics. Parameters, such as the cytokine profile (Human Th9/Th17/Th22 Luminex, Performance Assay 18-plex Fixed Panel, R&D Systems, Minneapolis, MN, USA) and additionally the Asthma Control Questionnaire (ACQ), mini-Asthma Quality of Life Questionnaire (mini-AQLQ), spirometry (FEV1, FEV/FVC), FeNO, and functional status, were assessed at baseline and after 3–4 months of therapy. Results: The biologic therapies demonstrated diverse effects on inflammatory biomarkers. Dupilumab showed the most pronounced decreases in CD40L, IL-6, and FeNO in comparison to other drugs. In turn, the greatest decrease in TNF-α concentration was observed in the group treated with mepolizumab. Conclusion: Changes in cytokine concentrations highlight the heterogenous immunomodulatory mechanisms of biologics and support personalized strategies based on inflammatory profiles. However, the results should be interpreted with prudence, as the concentrations of cytokines in blood serum fluctuate and the study sample size is small. Full article
(This article belongs to the Special Issue Molecular Signaling and Cellular Mechanisms in Asthma)
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