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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genome Editing and Biotechnology in Fruit Improvement
edited by Hongxia Miao
submission deadline 20 Jun 2026 | 1 articles | Viewed by 735 | Submission Open
Keywords: fruit improvement; horticultural crops; genome editing; biotechnology; molecular biology; plant genetics
(This special issue belongs to the Section Molecular Plant Sciences)
T-Cell Lymphoma: From Basic Science to Novel Therapeutics submission deadline 20 Jun 2026 | Viewed by 698 | Submission Open
Keywords: T-cell lymphoma; targeted therapy; immunotherapy; translational research; real-world experience
(This special issue belongs to the Section Molecular Oncology)
Hepatocellular Carcinoma: From Pathophysiology to Innovative Therapeutic Approaches
edited by Andrea Martini
submission deadline 20 Jun 2026 | Viewed by 694 | Submission Open
Keywords: liver carcinogenesis; tumor microenvironment; immune surveillance; fibrogenesis; inflammation
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Performances of Photocatalysis
edited by
submission deadline 20 Jun 2026 | Viewed by 679 | Submission Open
Keywords: photocatalytic materials; photocatalysis; energy conversion; environmental remediation; carbon dioxide reduction; organic synthesis
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Macrophage Plasticity: Beyond the M1–M2 Paradigm
edited by
submission deadline 20 Jun 2026 | Viewed by 658 | Submission Open
Keywords: macrophage; plasticity; microenvironment; polarization; epigenetic modulation; phagocytosis
(This special issue belongs to the Section Molecular Immunology)
The Current Landscape of Microglia-Glioma Research: From Basic Science to Therapeutic Potential submission deadline 20 Jun 2026 | Viewed by 651 | Submission Open
Keywords: microglia; glioma; tumor associated macrophages; immunosuppression; epigenetics
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment
edited by Madan Mohan Kwatra
submission deadline 20 Jun 2026 | 1 articles | Viewed by 646 | Submission Open
Keywords: glioblastoma; diagnosis; molecular characterization; personalized treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular-Scale Design and Applications of Food Packaging: Eco-Friendly Materials and Technologies
edited by and
submission deadline 20 Jun 2026 | Viewed by 629 | Submission Open
Keywords: sustainable packaging; biodegradable materials; smart packaging; active packaging; food safety; environmental impact
(This special issue belongs to the Section Materials Science)
Medicinal Plants, Animal-Derived Products, and Natural Compounds: Roles in Health and Disease submission deadline 20 Jun 2026 | 1 articles | Viewed by 617 | Submission Open
Keywords: natural bioactive compounds; medicinal plants; animal-derived products; marine natural products; chronic diseases; inflammation; oxidative stress; molecular mechanisms; therapeutic peptides; natural toxins; antioxidant activity; anti-inflammatory agents; nanoformulations; nanodelivery systems; drug delivery; pharmacological properties; translational research; integrative medicine; natural therapeutics; disease prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Cellular Aspects of Autoimmune and Inflammatory Rheumatic Diseases: Second Edition
edited by Marzena Helena Olesińska and Magdalena Szmyrka
submission deadline 20 Jun 2026 | Viewed by 580 | Submission Open
Keywords: autoimmune rheumatic diseases; inflammatory rheumatic diseases; arthritis; connective tissue diseases
(This special issue belongs to the Section Molecular Immunology)
Structure and Function of Subcellular Organelle and Protein-Membrane Systems
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 577 | Submission Open
Keywords: immuno-electron microscopy; cell signaling; comparative anatomy; diagnosis; molecular recognition; molecular complexes; electro-chemistry; liquid-phase synthesis; metal sedimentation; membrane endoskeleton
(This special issue belongs to the Section Molecular Biophysics)
Emerging Strategies in Tuberculosis Drug Discovery
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 566 | Submission Open
Keywords: anti-tuberculosis agents; MDR-TB; XDR-TB; drug repurposing; hybrid drugs; high-throughput screening; structure-based drug design; drug discovery
(This special issue belongs to the Section Molecular Pharmacology)
Unravelling Molecular Pathways in Ocular Disease and Degeneration submission deadline 20 Jun 2026 | 1 articles | Viewed by 564 | Submission Open
Keywords: molecular mechanisms; ocular disease; biomarkers; therapeutic targets; regenerative; gene therapies; corneal degeneration; retinal degeneration; optic nerve pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Allosteric Modulation of Kinases in Cancer Therapeutic Strategies and Challenges
edited by
submission deadline 20 Jun 2026 | Viewed by 554 | Submission Open
Keywords: kinase signaling; allosteric modulators; cancer therapy; drug resistance; molecular mechanisms; protein– protein interactions; targeted therapy; conformational changes; ATP-competitive inhibitors; drug design
(This special issue belongs to the Section Molecular Biology)
Metabolic Reprogramming in Health and Aging-Related Diseases
edited by
submission deadline 20 Jun 2026 | Viewed by 542 | Submission Open
Keywords: aging; degenerative diseases; lifestyle intervention; metabolic reprogramming; metabolic syndromes; metabolome; metabolomics; neurodegenerative diseases; omics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Insights into Skin Health and Disease
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 542 | Submission Open
Keywords: dermatology; molecular mechanisms; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on the Major Histocompatibility Complex (MHC): From Bench to Bedside
edited by Antonio Arnaiz-Villena
submission deadline 20 Jun 2026 | Viewed by 541 | Submission Open
Keywords: HLA; immunology; HLA genetics and pharmacogenetics; immune and other functions of the MHC; classical and nonclassical MHC class I HLA genes; HLA-G; HLA-E; HLA-F; MHC evolution; complement; autoimmunity; immunodeficiency; cancer; HIV
(This special issue belongs to the Section Molecular Immunology)
Molecular Advances and Insights into Liver Diseases: Second Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 533 | Submission Open
Keywords: liver; hepatocellular carcinoma; cancer; hepatitis cirrhosis; encephalopathy; non-alcoholic fatty liver disease; autoimmune diseases; Wilson’ s disease; fatty liver disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Valorization of Lignocellulosic Biomass: 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 500 | Submission Open
Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials
(This special issue belongs to the Section Materials Science)
Molecular Insights into the Pathophysiology of Placenta Accreta Spectrum
edited by Jessian L. Munoz
submission deadline 20 Jun 2026 | Viewed by 497 | Submission Open
Keywords: placenta accreta; invasive placenta; trophoblasts; placenta; high-risk pregnancy; placenta previa; in vitro fertilization; biomarkers; multi-omics research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research Progress on Photosensitizers and Photodynamic Therapy
edited by
submission deadline 20 Jun 2026 | Viewed by 496 | Submission Open
Keywords: photodynamic therapy; photosensitizers; tumor microenvironment; nanotechnology; immunotherapy; targeted drug delivery; reactive oxygen species; hypoxia; combination therapy; molecular mechanisms
(This special issue belongs to the Section Biochemistry)
Cell and Molecular Biology of Archaea
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 485 | Submission Open
Keywords: archaea; molecular biology; translation; gene expression regulation; biofilm; metabolism
(This special issue belongs to the Section Molecular Microbiology)
Urothelial Cancer: From Translational Medicine to Recent Innovations in Therapeutic Management
edited by Alessio Bruni
submission deadline 20 Jun 2026 | Viewed by 463 | Submission Open
Keywords: urothelial cancer; bladder cancer; radiation therapy; trimodality approach; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Genomics and Epigenetics of Stem Cell: An Update
edited by
submission deadline 20 Jun 2026 | Viewed by 462 | Submission Open
Keywords: stem cells; epigenetics; genomics; cell fate; self-renewal; differentiation; regenerative medicine; transcription factors
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Interplay Between Aging, Dementia and Renal Function: Mechanisms, Biomarkers and Therapeutic Targets
edited by
submission deadline 20 Jun 2026 | Viewed by 432 | Submission Open
Keywords: aging; dementia; neuroinflammation; kidney– brain axis; translational research; biomarkers; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Metabolism of Alzheimer’s Disease
edited by and Maria Letizia Trincavelli
submission deadline 20 Jun 2026 | Viewed by 426 | Submission Open
Keywords: Alzheimer’ s disease; brain metabolism; insulin resistance; lipid metabolism; APOE ε 4; metabolic targets; insulin-sensitizing drugs; lifestyle and metabolic interventions
(This special issue belongs to the Section Molecular Neurobiology)
Sphingolipids in Infections, Disorders and Diseases
edited by Elita Avota
submission deadline 20 Jun 2026 | Viewed by 424 | Submission Open
Keywords: sphingolipids; sphingolipid biosynthesis; sphingolipidoses; metabolic disorders; infections; lipidomics; sphingolipid targeting drugs
(This special issue belongs to the Section Biochemistry)
Immunology and Immunotherapy for Head and Neck Cancer
edited by
submission deadline 20 Jun 2026 | Viewed by 418 | Submission Open
Keywords: immunotherapy; head and neck cancer; toxicity management; immune system; nutrition; immune therapy and organ failure; mechanisms of immunotherapy resistance
(This special issue belongs to the Section Molecular Immunology)
Structural and Functional Insights into Chemokines and Chemokine Receptors in Immune Pathologies
edited by
submission deadline 20 Jun 2026 | Viewed by 413 | Submission Open
Keywords: chemokines; chemokine receptors; immune pathologies; signaling mechanisms; therapeutic targeting
(This special issue belongs to the Section Molecular Immunology)
Innovations in Photodynamic Therapy: New Horizons in Breast Cancer Care
edited by Sandeep Surendra Panikar
submission deadline 20 Jun 2026 | 1 articles | Viewed by 405 | Submission Open
Keywords: noninvasive therapy; tumor targeting; breast cancer therapy; oncology; photosensitizers; theranostics; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Neurobiology and Psychopharmacology of Mood Disorders
edited by
submission deadline 20 Jun 2026 | Viewed by 399 | Submission Open
Keywords: mood disorders; psychopharmacology; neurobiology; molecular mechanisms; biomarkers; translational psychiatry; neuroinflammation; signal transduction; animal models; epigenetics
(This special issue belongs to the Section Molecular Neurobiology)
Combined and Mixture Exposure Toxicology of Cancer and Chronic Diseases
edited by and Quentin Felty
submission deadline 20 Jun 2026 | Viewed by 390 | Submission Open
Keywords: combined exposure; mixture exposure; toxicology of cancer; omics of cancer; AI in carcinogenesis; machine learning use in cancer; cancer biomarkers; pollutants of cancer; agrochemicals; endocrine-disruptive chemicals
(This special issue belongs to the Section Molecular Oncology)
New Molecular Mechanisms and Markers in Inflammatory Disorders, 4th Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 385 | Submission Open
Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling
(This special issue belongs to the Section Molecular Immunology)
Natural Bioactive Compounds for Human Health, 3rd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 382 | Submission Open
Keywords: natural bioactive plant products; biological and pharmacological activity; natural plant drug discovery and development; nutraceuticals; botanical dietary supplement
(This special issue belongs to the Section Molecular Pharmacology)
Cellular Mechanisms of Pulmonary Arterial Hypertension
edited by and Saurabh Aggarwal
submission deadline 20 Jun 2026 | Viewed by 380 | Submission Open
Keywords: pulmonary arterial hypertension (PAH); pulmonary vascular remodeling; endothelial cells; endothelial dysfunction; smooth muscle cells; hyperplasia; pericytes; fibroblasts; monocytes; macrophage; neutrophil; mechanotransduction; oxidative stress; cytokines; extracellular vesicles; extracellular matrix; epigenetics; metabolism; biomarkers; therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced in In Silico Methods for Rational Drug Design and Predictive Toxicology
edited by
submission deadline 20 Jun 2026 | Viewed by 379 | Submission Open
Keywords: rational drug design; predictive toxicology; molecular modeling; AI in drug discovery; QSAR; molecular docking; ADMET
(This special issue belongs to the Section Molecular Informatics)
Molecular Horizons in Pain Therapeutics
edited by Alaa Abd-Elsayed
submission deadline 20 Jun 2026 | Viewed by 375 | Submission Open
Keywords: spinal cord stimulation; peripheral nerve stimulation; stem cell therapy; platelet-rich plasma (PRP) injections; chronic pain management; interventional pain procedure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Autoimmune Diseases: The Molecular Basis and New Therapies
edited by
submission deadline 20 Jun 2026 | Viewed by 371 | Submission Open
Keywords: autoimmunity; molecular mechanisms; biologics; immunotherapy; precision medicine
(This special issue belongs to the Section Molecular Immunology)
Eukaryotic Cells Under Stress: Biochemical and Physiological Mechanisms of Resistance and Resilience
edited by and
submission deadline 20 Jun 2026 | Viewed by 366 | Submission Open
Keywords: cellular stress response; oxidative stress; bioactive compounds; ROS; DNA damage/repair; environmental stressors; molecular chaperones; antioxidant in human diseases
(This special issue belongs to the Section Molecular Biology)
Surfactants: Design, Synthesis and Properties
edited by
submission deadline 20 Jun 2026 | Viewed by 360 | Submission Open
Keywords: design and synthesis of surfactants; adsorption and aggregation properties of surfactants; behavior of surfactants at different interfaces; application of biosurfactants and specialist surfactants (industry; agriculture; medicine; pharmacy)
(This special issue belongs to the Section Materials Science)
Graphene-Based Nanocomposites
edited by
submission deadline 20 Jun 2026 | Viewed by 355 | Submission Open
Keywords: graphite intercalates; graphene; reduced graphene oxide; grafting; vertical heterostructures; nanocomposites; covalent organic frameworks (COFs); 2D nanomaterials; biomimetic interfaces; interfacial engineering
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Regulatory Mechanisms of the Tumor Microenvironment in Human Diseases submission deadline 20 Jun 2026 | Viewed by 355 | Submission Open
Keywords: tumor microenvironment; cytokines; exosomes; non-tumor cells; tumor-associated immune cells; cancer prognosis; cancer diagnosis; oncotherapy
(This special issue belongs to the Section Molecular Oncology)
Interstitial Lung Diseases: From Molecular Pathology to New Treatments
edited by
submission deadline 20 Jun 2026 | Viewed by 354 | Submission Open
Keywords: interstitial lung diseases (ILDs); therapeutic strategies; molecular pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Design and Engineering of Carbon-Based Materials for Environmental Remediation and Bioenergy
edited by Hilda Elizabeth Reynel-Ávila
submission deadline 20 Jun 2026 | Viewed by 353 | Submission Open
Keywords: adsorption; catalysis; functionalization; molecular design; environmental; sustainable energy; tailoring
(This special issue belongs to the Section Materials Science)
Infectious Diseases and Infection Models in Laboratory Animals
edited by and Fumio Ike
submission deadline 20 Jun 2026 | Viewed by 351 | Submission Open
Keywords: infection model; Infectious diseases in laboratory animals; bacterial infection; viral infection; parasitic infection; molecular diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Sustainable Material Development: From Molecular Insights to Functional Applications
edited by
submission deadline 20 Jun 2026 | Viewed by 349 | Submission Open
Keywords: sustainable materials; biodegradable polymers; green chemistry; functional materials; structure– property relationships; chemical modification; recycling and upcycling; circular economy; composites; analytical techniques
(This special issue belongs to the Section Materials Science)
Precision Medicine for Cancer-Associated Thrombosis: The Role of Biomarkers
edited by Darko Antic
submission deadline 20 Jun 2026 | Viewed by 348 | Submission Open
Keywords: biomarkers; precision medicine; cancer-associated thrombosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Consensus-Based Approaches to Rational Drug Design and Predictive Toxicology submission deadline 20 Jun 2026 | Viewed by 346 | Submission Open
Keywords: drug design; bioactive compounds; pharmacophore; molecular dynamics; protein– ligand interactions; activity cliffs; machine learning
(This special issue belongs to the Section Molecular Toxicology)
Stress Signaling and Horticultural Crops Quality Control
edited by and
submission deadline 20 Jun 2026 | Viewed by 343 | Submission Open
Keywords: stress tolerance; molecular mechanisms; quality traits; redox regulation; postharvest physiology; signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Neuropharmacology in Neurodegenerative Disorders
edited by
submission deadline 20 Jun 2026 | Viewed by 337 | Submission Open
Keywords: neuropharmacology; neurodegenerative disorders; cognitive dysfunction; motor dysfunction; drug discovery; neuroprotection; neurogenesis; brain plasticity; biomarkers; AI (artificial intelligence)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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