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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Individualised Therapies for Rare Disorders
edited by Paul Gissen
submission deadline 31 May 2026 | Viewed by 197 | Submission Open
Keywords: individualised therapies; personalised medicine; rare diseases; omics; gene therapy; molecular pathways; mechanistic discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Adaptive Strategies of Plants to Water Stress
edited by Weitao Jia
submission deadline 31 May 2026 | Viewed by 190 | Submission Open
Keywords: adaptive strategies; submergence; post-submergence; waterlogging; drought; plant physiology; phenotypic plasticity; omics; epigenetic regulation; molecular mechanism
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Biomedical and Tissue Engineering Strategies to Cross the Blood–Brain Barrier for Next-Generation Treatments Against Neurodegenerative Diseases, 2nd Edition
edited by Livia La Barbera
submission deadline 31 May 2026 | Viewed by 190 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’ s disease; CNS; blood– brain barrier; drug delivery systems; nanocarriers; nanomedicine; tissue engineering; theranostics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Determinants of Chronic Diseases: Cellular Mechanisms and the Role of Natural Compounds
edited by Andrei Lobiuc
submission deadline 31 May 2026 | Viewed by 188 | Submission Open
Keywords: chronic diseases; natural compounds; cellular mechanisms; bioactive molecules; signal transduction; oxidative stress; inflammation; apoptosis; mitochondrial dysfunction; therapeutic targets
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Platelet-Mediated Immune Regulation in Cancer
edited by
submission deadline 31 May 2026 | Viewed by 178 | Submission Open
Keywords: platelets; tumor immunity; megakaryocyte; immunotherapy; lymphocytes; microvesicles; immune suppression; metastasis
(This special issue belongs to the Section Molecular Immunology)
Molecular Research on Development and Inhibition of Oral Biofilms
edited by Arunima Mishra
submission deadline 31 May 2026 | Viewed by 166 | Submission Open
Keywords: oral biofilms; dental plaque; biofilm structure/architecture; oral biofilm management; quorum-sensing inhibitors; anti-microbial peptides; glucosyltransferases; coaggregation
(This special issue belongs to the Section Molecular Microbiology)
Spike Protein Receptor submission deadline 31 May 2026 | Viewed by 152 | Submission Open
Keywords: spike protein; receptor binding; ACE2 interaction; viral entry; structural virology; immune recognition; antibody and IgA epitopes; variant transmissibility; receptor-blocking therapeutics
(This special issue belongs to the Section Molecular Biophysics)
Molecular Research on Reproductive Physiology and Endocrinology
edited by
submission deadline 20 Jun 2026 | 20 articles | Viewed by 99550 | Submission Open
Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Long-COVID and Its Complications
edited by
submission deadline 20 Jun 2026 | 14 articles | Viewed by 58438 | Submission Open
Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications
edited by
submission deadline 20 Jun 2026 | 13 articles | Viewed by 45718 | Submission Open
Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Basis of Neuropsychiatric Disorders: Recent and Future Developments submission deadline 20 Jun 2026 | 6 articles | Viewed by 33877 | Submission Open
Keywords: molecular; schizophrenia; depression; genetic; autism; mechanisms; genetic
(This special issue belongs to the Section Molecular Neurobiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology
edited by
submission deadline 20 Jun 2026 | 17 articles | Viewed by 27425 | Submission Open
Keywords: bacteria fungi; bacteriophages; microalgae; microbiome; gut microbiota; environmental microbiome; microbiome– brain– gut axis; virus– host interactions; emerging viruses re-emerging viruses; virus mutation; biofilm antimicrobial; SARS-CoV-2 (COVID-19)
(This special issue belongs to the Section Molecular Microbiology)
Pathophysiology of Hair Loss
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 24125 | Submission Open
Keywords: Hair Loss; Pathophysiology; Molecular Mechanisms; Genetic Mutations; Signaling Pathways; Nutrient Interactions; Personalized Therapies; Targeted Drug Delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Phytochemicals of Natural Products: Source, Analysis, and Bioactivities
edited by , Chi-I Chang and Chi-Chien Lin
submission deadline 20 Jun 2026 | 6 articles | Viewed by 23905 | Submission Open
Keywords: phytochemicals; bioactive compounds; natural products; bioactivities; purification; chemoprevention; chemotherapy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Transporters in Health and Disease submission deadline 20 Jun 2026 | 10 articles | Viewed by 23709 | Submission Open
Keywords: transporters; disease; regulation; drugs; toxicity; signaling
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Functional Products for Health Prevention and Promotion
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 22964 | Submission Open
Keywords: functional foods; food fortification; biofortification; bioactive food ingredients; human nutrition; nutrition and immunity; health prevention; chronic non-communicable diseases; epigenetics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Toxicity of Metals, Metal-Based Drugs, and Microplastics submission deadline 20 Jun 2026 | 7 articles | Viewed by 22333 | Submission Open
Keywords: metal toxicity and pollution; microplastic toxicity and pollution; metal and microplastic bioaccumulation; metal-based drugs; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies
(This special issue belongs to the Section Molecular Toxicology)
Coronavirus Disease (COVID-19): Pathophysiology (6th Edition) submission deadline 20 Jun 2026 | 6 articles | Viewed by 18426 | Submission Open
Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeting Glioblastoma Metabolism submission deadline 20 Jun 2026 | 5 articles | Viewed by 18103 | Submission Open
Keywords: glioblastoma; metabolic heterogeneity; metabolic reprogramming; cancer stem cells; therapeutic resistance; metabolic vulnerabilities; IDH1/2 mutations; tumor microenvironment; epigenetic regulation
(This special issue belongs to the Section Molecular Oncology)
Cheminformatics in Drug Discovery and Green Synthesis
edited by
submission deadline 20 Jun 2026 | 8 articles | Viewed by 17308 | Submission Open
Keywords: cheminformatics; drug discovery; databases; in silico methods; green chemistry
(This special issue belongs to the Section Molecular Informatics)
Antioxidant and Antibacterial Properties of Phytochemicals
edited by and Vytaute Starkute
submission deadline 20 Jun 2026 | 5 articles | Viewed by 16629 | Submission Open
Keywords: phytochemicals; natural preservatives; antioxidants; antibacterial properties; food; cosmetics; pharmaceuticals; animal feed
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Microbiomes in Human Health and Disease
edited by
submission deadline 20 Jun 2026 | 8 articles | Viewed by 16604 | Submission Open
Keywords: microbiome; dysbiosis; commensal bacteria; pathobiont; metabolites; immune modulation; nutrient metabolism; barrier function; health and disease
(This special issue belongs to the Section Molecular Microbiology)
Advances in Neurodegenerative Diseases and Inflammation: Pathogenesis, Biomarkers and Treatments
edited by and Anna Maria Ciaccio
submission deadline 20 Jun 2026 | 6 articles | Viewed by 16431 | Submission Open
Keywords: neurodegeneration; inflammation; biomarkers; Alzheimer’ s disease; molecular mechanism; pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Natural Products for Human Health and Disease
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 16355 | Submission Open
Keywords: medicinal plants; phytochemistry; bioactive compounds; metabolomics; proteomics; antioxidants; signal transduction; immunomodulation; phytopharmacology; ethnopharmacology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Role and Application of Stem Cells in Regenerative Medicine (Volume 5) submission deadline 20 Jun 2026 | 5 articles | Viewed by 15770 | Submission Open
Keywords: mesenchymal stem cells; tissue regeneration; regenerative medicine; immunomodulatory process
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 15478 | Submission Open
Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’ s disease; therapeutics; healthy aging
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Biomarkers for Targeted Therapies
edited by Vija Lavinia
submission deadline 20 Jun 2026 | 10 articles | Viewed by 14930 | Submission Open
Keywords: biomarkers; molecular targeted radiotherapies; prognostic biomarkers; predictive biomarkers; single or composite biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis of Advanced Polymer Materials, 3rd Edition
edited by
submission deadline 20 Jun 2026 | 5 articles | Viewed by 14292 | Submission Open
Keywords: polymer synthesis; polymer chemistry; coordination polymerization; organometallic catalysts; polyolefin; degradable polymer materials; green and sustainable polymeric materials; homogeneous polymerization; heterogeneous polymerization
(This special issue belongs to the Section Macromolecules)
Myocardial Disease: Molecular Pathology and Treatments
edited by
submission deadline 20 Jun 2026 | 5 articles | Viewed by 13958 | Submission Open
Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; amyloidosis; myocarditis; sarcoidosis; genetic abnormalities; immune mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
25th Anniversary of IJMS: Updates and Advances in "Materials Science" Section submission deadline 20 Jun 2026 | 10 articles | Viewed by 13762 | Submission Open
Keywords: nanomaterials; functional polymers; bio-inspired systems; complex intelligent; responsive materials
(This special issue belongs to the Section Materials Science)
New Molecular Insights into Ischemia/Reperfusion: 2nd Edition
edited by
submission deadline 20 Jun 2026 | 10 articles | Viewed by 13597 | Submission Open
Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oxidative Stress in Human Diseases
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 13418 | Submission Open
Keywords: inflammation; oxidative stress; free radicals; proteins; lipids; DNA damage; biomarkers
(This special issue belongs to the Section Biochemistry)
Molecular Mechanism of Acute Myeloid Leukemia
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 12881 | Submission Open
Keywords: leukemia; cytokine; signal transduction; apoptosis; immune therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Biomarkers of Central Nervous System Diseases and Disorders
edited by and
submission deadline 20 Jun 2026 | 7 articles | Viewed by 12168 | Submission Open
Keywords: RNA biomarkers; CNS disorders; autism spectrum disorder; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Tissue Engineering Related Biomaterials: Progress and Challenges
edited by , and Cristina Elena Dinu-Pirvu
submission deadline 20 Jun 2026 | 5 articles | Viewed by 12101 | Submission Open
Keywords: biomaterials; tissue engineering; scaffold materials; regenerative medicine; cell– material interactions; tissue regeneration; bioactive materials; nanotechnology in tissue engineering; electrospinning; 3D printing; biodegradable materials; growth factors
(This special issue belongs to the Section Materials Science)
The Application of Machine Learning to Molecular Dynamics Simulations
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 11663 | Submission Open
Keywords: molecular dynamics simulations; machine learning; AI in drug discovery; pharmacokinetics prediction; protein folding simulations; toxicity prediction using ML; free energy calculations; virtual screening; protein– ligand interactions; protein– protein interactions
(This special issue belongs to the Section Molecular Informatics)
Therapeutic Potential of Antioxidants in the Prevention of Human Diseases, 2nd Edition
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 11538 | Submission Open
Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes, 2nd Edition submission deadline 20 Jun 2026 | 4 articles | Viewed by 11449 | Submission Open
Keywords: extracellular vesicles; exosomes intercellular; crosstalk liquid biopsy carcinogenesis; cell differentiation tissue; homeostasis; organ remodeling; biomedicine; advanced diagnostics
(This special issue belongs to the Section Molecular Immunology)
Deciphering Molecular Complexity of Pancreatic Cancer submission deadline 20 Jun 2026 | 5 articles | Viewed by 11351 | Submission Open
Keywords: pancreatic cancer; intratumor heterogeneity; bulk and single-cell multiomics; tumor microenvironment; cancer immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Microglia in Neurological Disorders: Potential Therapeutic Targets and Underlying Mechanisms
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 11245 | Submission Open
Keywords: cerebral amyloid angiopathy; Alzheimer's disease; amyloid-β fibril formation
(This special issue belongs to the Section Molecular Neurobiology)
Mesenchymal Stem/Stromal Cells: Mechanisms and Applications in Tissue Regeneration
edited by
submission deadline 20 Jun 2026 | 7 articles | Viewed by 11054 | Submission Open
Keywords: MSC isolation; identification; and viability; MSC differentiation mechanisms; extracellular environment modifications; intracellular signalling systems; cytotoxicity investigations; tissue regeneration mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Hematologic Malignancies
edited by and
submission deadline 20 Jun 2026 | 6 articles | Viewed by 10893 | Submission Open
Keywords: therapeutic targets; leukemogenesis; molecular regulation; cancer stem cells; epigenetics; novel biomarkers; non-coding RNA; DNA methylation; chemotherapy and genetic changes; cancer; hematologic malignancies
(This special issue belongs to the Section Molecular Oncology)
Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis
edited by and Jeffrey R. Koenitzer
submission deadline 20 Jun 2026 | 4 articles | Viewed by 10445 | Submission Open
Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins
(This special issue belongs to the Section Molecular Biology)
Natural Products and Synthetic Compounds for Drug Development: 3rd Edition
edited by
submission deadline 20 Jun 2026 | 5 articles | Viewed by 10352 | Submission Open
Keywords: reactive oxygen; anti-inflammation; cancer; infectious diseases; liver diseases; lung disease; kidney disease; cardiac disease; neuro disease
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Advances in Skin Diseases: 3rd Edition
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 10183 | Submission Open
Keywords: infection; inflammation; molecular; neoplasm; pathogenesis; skin diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Network Pharmacology: An Emerging Field in Drug Discovery (2nd Edition)
edited by
submission deadline 20 Jun 2026 | 7 articles | Viewed by 10173 | Submission Open
Keywords: network pharmacology; machine learning; databases; drug discovery; computer-aided drug design (CADD); data mining
(This special issue belongs to the Section Molecular Pharmacology)
Multi-Omics Approaches to Disentangle Pathomechanisms in Neurological Disease submission deadline 20 Jun 2026 | 4 articles | Viewed by 9591 | Submission Open
Keywords: neurological diseases; molecular mechanisms; neurodegeneration; omics; bioinformatics; disease biomarkers; biochemical pathways; diagnostic and therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research and Potential Effects of Medicinal Plants
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 9349 | Submission Open
Keywords: medicinal plants; natural products; disease treatment; drug screening; bioassays
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights into Adipose Tissue Metabolic Function and Dysfunction, 4th Edition
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 9344 | Submission Open
Keywords: inflammation; browning; thermogenesis; adipogenesis; diabetes; adipokines; energy storage; insulin resistance; obesity; lipolysis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Benchmarking of Modeling and Informatic Methods in Molecular Sciences
edited by Abby Parrill
submission deadline 20 Jun 2026 | 7 articles | Viewed by 9257 | Submission Open
Keywords: modeling; informatics; simulation; benchmarking; performance comparison; modeling method evaluation; informatic method evaluation
(This special issue belongs to the Section Molecular Informatics)
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