Leukemia: Molecular Immune Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (20 June 2026) | Viewed by 2460
Editor
Interests: targeted cancer therapy; tyrosine kinase inhibitors; small molecule inhibitors; apoptosis; monoclonal antibodies; immunomodulators; leukemia; lymphoma; acquired drug resistance; intracellular signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Leukemia is a group of blood cancers characterized by the uncontrolled proliferation of white blood cells, presenting a significant health concern for humans. Understanding the molecular and immune mechanisms involved is crucial for developing effective therapies. Key factors that can lead to leukemia include the following: 1. Genetic Mutations and Alterations: This encompasses mutations in oncogenes and tumor suppressor genes (e.g., FLT3, NPM1, and TP53) as well as chromosomal translocations (e.g., BCR-ABL in chronic myeloid leukemia). 2. Immune Evasion Mechanisms: These involve an immunosuppressive microenvironment that protects leukemia cells from the immune response. 3. Immune Cell Dysfunction: This includes altered T cell function and impairment of Natural Killer cells. 4. Cytokine Networks: The presence of pro-inflammatory cytokines and cytokine storms can contribute to leukemia progression. 5. Changes in the Bone Marrow Microenvironment: Interactions within the niche and components of the extracellular matrix play a role in leukemia cell survival and proliferation. Various treatment approaches are being explored, including small molecule inhibitors and immunotherapy strategies such as CAR T-cell therapy and immune checkpoint inhibitors. In conclusion, the relationship between leukemic cells and the immune system is complex and involves genetic, molecular, and environmental factors. Advances in understanding these mechanisms are paving the way for new therapeutic strategies that utilize the immune system to more effectively combat leukemia. Ongoing research in these areas is essential for improving patient outcomes.
Dr. Mohammad Hojjat-Farsangi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- leukemia
- immune system
- Genetic Mutations and Alterations
- Immune Evasion Mechanisms
- Immune Cell Dysfunction
- Cytokine Networks
- Bone Marrow Microenvironment
- immunotherapy strategies
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
