Leukemia: Molecular Immune Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 1429
Special Issue Editor
Interests: targeted cancer therapy; tyrosine kinase inhibitors; small molecule inhibitors; apoptosis; monoclonal antibodies; immunomodulators; leukemia; lymphoma; acquired drug resistance; intracellular signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Leukemia is a group of blood cancers characterized by the uncontrolled proliferation of white blood cells, presenting a significant health concern for humans. Understanding the molecular and immune mechanisms involved is crucial for developing effective therapies. Key factors that can lead to leukemia include the following: 1. Genetic Mutations and Alterations: This encompasses mutations in oncogenes and tumor suppressor genes (e.g., FLT3, NPM1, and TP53) as well as chromosomal translocations (e.g., BCR-ABL in chronic myeloid leukemia). 2. Immune Evasion Mechanisms: These involve an immunosuppressive microenvironment that protects leukemia cells from the immune response. 3. Immune Cell Dysfunction: This includes altered T cell function and impairment of Natural Killer cells. 4. Cytokine Networks: The presence of pro-inflammatory cytokines and cytokine storms can contribute to leukemia progression. 5. Changes in the Bone Marrow Microenvironment: Interactions within the niche and components of the extracellular matrix play a role in leukemia cell survival and proliferation. Various treatment approaches are being explored, including small molecule inhibitors and immunotherapy strategies such as CAR T-cell therapy and immune checkpoint inhibitors. In conclusion, the relationship between leukemic cells and the immune system is complex and involves genetic, molecular, and environmental factors. Advances in understanding these mechanisms are paving the way for new therapeutic strategies that utilize the immune system to more effectively combat leukemia. Ongoing research in these areas is essential for improving patient outcomes.
Dr. Mohammad Hojjat-Farsangi
Guest Editor
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Keywords
- leukemia
- immune system
- Genetic Mutations and Alterations
- Immune Evasion Mechanisms
- Immune Cell Dysfunction
- Cytokine Networks
- Bone Marrow Microenvironment
- immunotherapy strategies
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