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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Microglia in Neurological Disorders: Potential Therapeutic Targets and Underlying Mechanisms

edited by

Masashi Tanaka

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4947 | Submission Open

Keywords: cerebral amyloid angiopathy; Alzheimer's disease; amyloid-β fibril formation

(This special issue belongs to the Section Molecular Neurobiology)

Mitochondrial Biology and Reactive Oxygen Species

edited by

Wieslawa Jarmuszkiewicz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4908 | Submission Open

Keywords: mitochondrial biology; mitochondrial dysfunction; mitochondrial coenzyme Q; metabolic homeostasis; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics

edited by

Pulak R. Manna

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4874 | Submission Open

Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’ s disease; therapeutics; healthy aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Recent Advances in Soybean Molecular Breeding

edited by Dong Cao

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4813 | Submission Open

Keywords: soybean; plant architecture; adaptation; yield improvement; molecular breeding; nutritional quality traits; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Biomarkers of Central Nervous System Diseases and Disorders

edited by

David Gurwitz

and

Chiara Villa

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4766 | Submission Open

Keywords: RNA biomarkers; CNS disorders; autism spectrum disorder; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research in Hematologic Malignancies

edited by

Rachid Lahlil

and

Anne Aries

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4765 | Submission Open

Keywords: therapeutic targets; leukemogenesis; molecular regulation; cancer stem cells; epigenetics; novel biomarkers; non-coding RNA; DNA methylation; chemotherapy and genetic changes; cancer; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Iron Metabolism, Ferritin and Hepcidin Research: 3rd Edition

edited by

Edina Pandur

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4325 | Submission Open

Keywords: iron; hepcidin; ferroportin; ferritin; regulation; anemia; therapies; cell signaling; inflammation; disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cardiovascular Diseases: Aging and Other Risk Factors

edited by

Silvia Liskova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4135 | Submission Open

Keywords: aging; hypertension; endothelium; vascular smooth muscle cells; pulmonary hypertension; atherosclerosis; hyperlipidemia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunophenotyping in Autoimmune Diseases and Cancer, 4th Edition

edited by

Gabor J. Szebeni

and

Attila Balog

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3901 | Submission Open

Keywords: immunophenotyping; immune regulation; multiparameter cytometry; immuno-oncology; anti-tumor immunity; autoimmunity; cancer immunology; protein– protein interactions; structure/function relationships; sulfur amino acids

(This special issue belongs to the Section Molecular Immunology)

Exploring the Cytoskeleton and Its Regulators: From Structure to Function

edited by

Wan Lee

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3730 | Submission Open

Keywords: cytoskeleton; cytoskeleton-binding protein; cytoskeletal protein; cell signaling; mechanotransduction; cell proliferation; cell migration; cellular motility; cell differentiation; structural biology

(This special issue belongs to the Section Molecular Biology)

Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

edited by

Montserrat Fernández-Guarino

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3661 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Translational Oncology: From Molecular Basis to Therapy

edited by

Mario Cioce

and Gatti Veronica

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3392 | Submission Open

Keywords: cancer; therapy resistance; translational oncology; cancer stem cells; immunotherapy; cancer metabolism; OMICS; patient-derived-organoids; drug repositioning; TKI

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Neurological and Psychiatric Disease, 2nd Edition

edited by

Giuseppina Martella

and Maria Meringolo

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3271 | Submission Open

Keywords: Alzheimer's and Parkinson's diseases; epilepsy; migraine; essential tremors; stroke; depression; anxiety disorders; cognitive impairment

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Treatment of Retinal Diseases

edited by

Deokho Lee

and

Livio Vitiello

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3091 | Submission Open

Keywords: nutritional supplementations; high myopia; optometry; cell therapy; drug delivery; age-related macular degeneration; glaucoma; retinal degeneration; choroidal thinning; scleral remodeling; light therapy; digital healthcare; prematurity of retionopathy; carotid artery occlusion; retinal ischemia; inflammation; eye drop

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Cages: Design, Synthesis, and Applications

edited by

Vicente Martí-Centelles

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2863 | Submission Open

Keywords: molecular cages; supramolecular chemistry; synthetic chemistry; self-assembly; molecular design; host– guest chemistry; biological applications

(This special issue belongs to the Section Macromolecules)

Pancreatic Disease: From Molecular Basis to Novel Therapies—2nd Edition

edited by

Agnieszka B. Bialkowska

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2580 | Submission Open

Keywords: pancreatitis; acinar-to-ductal neoplasia; early pancreatic neoplasia; fibroinflammatory disease; pancreatic cancer; diabetes Mellitus

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI

edited by

Yuriy L. Orlov

and

Ming Chen

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2458 | Submission Open

Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant– pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants

(This special issue belongs to the Section Molecular Informatics)

Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications

edited by

Ariel Fernando Castro

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2434 | Submission Open

Keywords: oncogenes; tumor suppressors; cancer biology; molecular mechanisms; tumor microenvironment; biomarkers; targeted cancer therapy; cancer initiation and progression

(This special issue belongs to the Section Molecular Oncology)

Steroids in Human Disease and Health

edited by

Martin Hill

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2318 | Submission Open

Keywords: steroid metabolism; steroids and endocrinopathies; steroids and inflammation; corticosteroids; mineralocorticoids; neuroactive steroids; steroids and neuropsychiatric diseases; steroids and reproduction; steroidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Impact of Circulatory and Blood Clotting Dysfunctions in Infectious Diseases

edited by

Hsin-Hou Chang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2311 | Submission Open

Keywords: infectious diseases; circulatory dysfunction; coagulation disorders; endothelial activation; platelet aggregation; anticoagulant therapy; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into the Developmental Origins of Health and Disease, 2nd Edition

edited by

Paramjit S. Tappia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2247 | Submission Open

Keywords: Developmental Origins of Health and Disease (DOHaD); fetal development; maternal nutrition; molecular programming; epigenetic modifications; environmental exposures; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Compounds in Immune-Inflammatory Regulation: Mechanisms and Therapeutics

edited by Dae-Hun Park, Chun-Sik Bae and

Seung-Sik Cho

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2193 | Submission Open

Keywords: natural compound; immune-inflammatory regulation; mechanism; cytokine; NF-κ B/COX-2; PGE2

(This special issue belongs to the Section Molecular Immunology)

Bioinformatics of Gene Regulations and Structure–2025

edited by

Yuriy L. Orlov

Anastasia Anashkina

and

Nikolay A. Kolchanov

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2127 | Submission Open

Keywords: gene expression regulation; bioinformatics and systems biology; NGS data analysis of gene expression; ncRNA networks; computer genomics of model organisms; fundamental biomedicine model; regulatory gene networks; AI tools in bioinformatics

(This special issue belongs to the Section Molecular Informatics)

The Innate Immune System in Renal Diseases

edited by

Takashi Oda

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1998 | Submission Open

Keywords: innate immune system; acquired immunity; complement system; dendritic cells; monocyte/macrophages (Mϕ); polymorphonuclear leukocytes; NK/NKT cells; innate lymphoid cells (ILCs); AKI; CKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Study on Organellar Genomes of Vascular Plants

edited by

Monika Szczecińska

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1992 | Submission Open

Keywords: mitochondrial DNA (mtDNA); chloroplast DNA (cpDNA); plant evolution; plant organellar genome; genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Circulating Biomarkers for the Diagnosis of Cancer

edited by Fernando Luiz Affonso Fonseca

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1980 | Submission Open

Keywords: biomarkers; circulating ; lab methods; diagnosis; screening

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Venom and Antivenom

edited by

Vance G. Nielsen

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1848 | Submission Open

Keywords: venom; antivenom; mass spectroscopy; spectrophotometry; thromboelastography; coagulation; neuromuscular junction

(This special issue belongs to the Section Molecular Toxicology)

State-of-the-Art Molecular Genetics and Genomics in Poland: 3rd Edition

edited by

Ewa Fiedorowicz

and

Anna Cieślińska

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1790 | Submission Open

Keywords: RNA; DNA; DNA structure; damage; and repair; post-translational modifications; autophagy; cell cycle; gene expression; functions and therapy; mutation; nuclear organization; polymerase; nucleic acid– protein interactions; molecular clone; sequencing analysis; epigenetics; transcriptomics; genetics of aging; genetic disorders; SNP; etc

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence

edited by

Nuno Taveira

and Inês Bártolo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1776 | Submission Open

Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus– host interactions; HIV eradication strategies

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Mechanisms of Blood–Brain Barrier (BBB) Dysfunction and Dementia

edited by Mark Slevin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1769 | Submission Open

Keywords: blood– brain barrier; Alzheimer’ s disease; endothelial dysfunction; amyloid beta; tau; neuroinflammation; oxidative stress; aging; gut– brain axis; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Micro-RNA in Gastrointestinal Cancers—from Molecules to Novel Therapies

edited by

Jacek Baj

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1682 | Submission Open

Keywords: micro-RNA; gastrointestinal cancer; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; neuroendocrine tumor; esophageal cancer; gallbladder cancer; rectal cancer

(This special issue belongs to the Section Molecular Oncology)

Enhancing Stem Cell Grafting in Tissue Regeneration and Repair

edited by

Yuanyuan Zhang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1632 | Submission Open

Keywords: stem cell therapy; tissue regeneration; graft enhancement; molecular mechanisms; engraftment; biomaterials; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Highlights in Pathophysiology of the Musculoskeletal System, 3rd Edition

edited by

Marta Anna Szychlinska

Rosario Barone

and

Giovanna Calabrese

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1591 | Submission Open

Keywords: musculoskeletal; skeletal; tendon; ligament; intervertebral; articular cartilage; osteoarthritis; rheumatoid arthritis; sarcopenia; muscle wasting; osteoporosis; bone necrosis; synovium; pain; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Climate Change Mitigation Strategies in Grapevine Molecular, Biochemical, and Physiological Performance

edited by

Sandra Pereira

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1536 | Submission Open

Keywords: grapevine growth; climate change; abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Modeling: Latest Advances and Applications, 2nd Edition

edited by

Maria Alexandra Mernea

and

Dan Florin Mihǎilescu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1468 | Submission Open

Keywords: molecular modeling; computational chemistry; drug design; material science; biomolecular interactions; algorithmic advances; theoretical chemistry; simulation techniques; predictive modeling; interdisciplinary applications

(This special issue belongs to the Section Molecular Biophysics)

Mechanisms of Resistance to Melanoma Immunotherapy

edited by Marko B. Lens

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1433 | Submission Open

Keywords: melanoma; immune checkpoint inhibitors; PD-1

(This special issue belongs to the Section Molecular Oncology)

Molecular Studies on Microbial Degradation of Emerging Pollutants Toxic to Human Health

edited by

Yang Yang

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1371 | Submission Open

Keywords: microbial degradation; emerging pollutants and organic pollutants; bacteria; fungi; enzyme

(This special issue belongs to the Section Molecular Microbiology)

The Latest Development of Molecular Research in Animal Nutrition

edited by

Mohammad Moniruzzaman

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1370 | Submission Open

Keywords: animal nutrition; molecular biology; microbiome; feed efficiency; sustainable aquaculture; proteomics; metabolomics; molecular mechanisms; metabolic regulation; disease resistance

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Non-Coding RNAs’ Functionality—Diagnosis and Therapy in Cancer and Other Indications (2nd Edition)

edited by

Mohamed Raafat El-Gewely

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1360 | Submission Open

Keywords: non-coding RNAs (ncRNAs); long non-coding RNAs (lncRNAs); MicroRNAs (miRNAs); circular RNAs (circRNAs); epigenetic and post-transcriptional regulation; epithelial– mesenchymal transition (EMT); cell proliferation and Apoptosis; biomarkers and Liquid biopsy; RNA-based therapeutics; next-generation sequencing (NGS); CRISPR/Cas9 screening; single-cell RNA sequencing (scRNA-seq); RNA interference (RNAi); cancer stem cells; early cancer diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nutrition, Inflammation, and Chronic Kidney Disease

edited by

Denise Mafra

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1342 | Submission Open

Keywords: chronic kidney disease; inflammation; nutrients; bioactive compounds

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology of Foodborne Pathogens: Pathogenesis and Control Strategies

edited by

Jaewoo Bai

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1336 | Submission Open

Keywords: foodborne pathogens; molecular pathogenesis; virulence factor; virulence genes; host– pathogen interaction; antimicrobial resistance; bioinformatics; omics technology; rapid detection and diagnostics; control strategies; food safety

(This special issue belongs to the Section Molecular Microbiology)

Advances in Traits in Animals and Aquatic Species, and Their Improvement Technologies

edited by

Lishi Yang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1284 | Submission Open

Keywords: biotechnology; genetic breeding; stress responses; epigenetics; non-coding RNAs; gene regulation; molecular ecology; animals; aquaculture; development

(This special issue belongs to the Section Molecular Biology)

Structural Codes of Sphingolipids and Their Involvement in Diseases

edited by

Sandro Sonnino

and

Elena Chiricozzi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1199 | Submission Open

Keywords: sphingolipids; sphingolipid hydrophilic head; sphingolipid hydrophobic tail; sphingolipid signalling; sphingolipid diseases

(This special issue belongs to the Section Biochemistry)

Cyclic Nucleotide-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects

edited by

Jens Schlossmann

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1161 | Submission Open

Keywords: cyclic nucleotide; cNMP; cAMP; cGMP; cCMP; cUMP; cGAMP; signaling proteins; signal transduction pathways; scaffolds; nitric oxide; natriuretic peptides; adenylyl cyclases; guanylyl cyclases; kinases; phosphodiesterases; channels; (patho)physiology; pharmacology

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms Governing Lipid Metabolism in Health and Disease

edited by

Christina E. Kostara

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1102 | Submission Open

Keywords: lipidomics; lipid biomarkers; lipid metabolism; cardiovascular disease; cardiometabolic diseases; non-alcoholic fatty liver disease; diabetes; lipoproteins; NMR spectroscopy; mass spectrometry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

In Silico Approaches to Unravelling Toxicity Mechanisms in Molecular Drugs

edited by

Yoshihiro Uesawa

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1076 | Submission Open

Keywords: cheminformatics; in silico analysis; QSAR; toxicity prediction; machine learning; toxicity mechanisms; omics data integration; toxicity biomarkers; artificial intelligence; adverse event database

(This special issue belongs to the Section Molecular Pharmacology)

Pathogenesis and Treatments of Head and Neck Cancer: 2nd Edition

edited by

Marko Tarle

submission deadline 30 Nov 2025 | 1 articles | Viewed by 967 | Submission Open

Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathology of the Placenta in Pregnancy Complications

edited by

Zoltan Kozinszky

and

Andrea Suranyi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 966 | Submission Open

Keywords: pregnancy complications; placental histology; biomarker; trophoblast invasion; molecular diagnostics and therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Nanotechnology for Natural Products

edited by

Carmen Lizette Del Toro Sánchez

submission deadline 30 Nov 2025 | 1 articles | Viewed by 961 | Submission Open

Keywords: molecular nanotechnology; natural products; bioactive compounds; nanocarriers; targeted delivery; encapsulation; bioavailability; pharmacological applications; food applications; biomedical nanotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antibacterial Nanomaterials for Medicinal Applications

edited by

Tsung-Rong Kuo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 934 | Submission Open

Keywords: nanotechnology; antibacterial; nanomaterials; toxicity; biocompatibility; medicinal applications

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 301-350 on page 7 of 69.

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