Molecular Research in Hematologic Malignancies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 9
Special Issue Editors
Interests: stem cells; leukemia; biomarkers; mechanisms of multi-drug; epigenetic
Special Issues, Collections and Topics in MDPI journals
Interests: stem cell research; cell therapy; epigenetic regulation in hematologic malignancies; molecular research; non-coding RNAs; DNA methylation; non-invasive diagnosis; regenerative medicine
Special Issue Information
Dear Colleagues,
The molecular regulation of hematopoietic stem cells (HSCs), including their proliferation, self-renewal, and differentiation, plays a central role in the development and progression of hematologic malignancies. A thorough understanding of these regulatory mechanisms, alongside the identification of novel pathways and biomarkers such as mutations, differentially methylated regions, and non-coding RNAs, is crucial for enhancing diagnostic precision, prognostic assessment, and the development of targeted therapies.
The field of molecular diagnostics and therapeutics in hematopoietic malignancies is currently at a pivotal juncture. Despite significant progress, the molecular determinants that predispose specific healthy cell populations to oncogenic reprogramming and the acquisition of aberrant self-renewal capacity remain insufficiently characterized.
This Special Issue aims to highlight recent advances in the molecular regulation of normal hematopoiesis and the mechanisms that promote leukemogenesis. It also seeks to address existing gaps in the knowledge and propose future directions for innovative diagnostic and therapeutic approaches. We welcome the submission of original research articles and comprehensive reviews on the following topics:
- Molecular mechanisms regulating hematopoiesis;
- Drivers of malignant transformation;
- Non-invasive diagnostic and prognostic strategies and innovations;
- Emerging targeted therapies in hematologic malignancies.
Dr. Rachid Lahlil
Dr. Anne Aries
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- therapeutic targets
- leukemogenesis
- molecular regulation
- cancer stem cells
- epigenetics
- novel biomarkers
- non-coding RNA
- DNA methylation
- chemotherapy and genetic changes
- cancer
- hematologic malignancies
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