Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 1
Special Issue Editor
Interests: aging and comorbidities; hormone regulation and function; endocrine physiology and pathophysiology; signal transduction pathways; steroidogenesis; hormonal alterations in aging; tumorigenesis; genetics and epigenetics; immunomodulation; neurodegenerative processes; therapeutic strategies
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Special Issue Information
Dear Colleagues,
The maintenance of bodily homeostasis is contingent on the appropriate functioning of a wide range of hormones. A hallmark of healthy physiology is the ability to sense, respond to, and control innumerable processes, in which hormones play indispensable roles. Dysregulation of hormonal stability, including sex hormones and neurosteroids, is a primary cause of human senescence, resulting in a variety of health complications and diseases. Aging is an unavoidable heterogeneous phenomenon involving the whole organism in which the structural and functional efficacies of a multitude of organs are deteriorated and results in endocrino-immuno-senescence. Disruption of age-associated hormonal equilibrium involves the hypothalamic-pituitary-gonadal axes (hypogonadism), estrogen and progesterone (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulfate (adrenopause), which profoundly affect geriatric populations worldwide. The manifestations of hormonal/steroidal deficiencies include, but are not limited to, diminished eyesight, impaired memory and cognitive function, decreased muscle mass and bone density, sexual dysfunction and depression, increased risk of cardiovascular diseases (CVDs), and skin disorders, which modulate the immune system and contribute to increased morbidity and mortality. Moreover, aging is the primary risk factor for diverse pathologic events, especially hormone-sensitive breast and other relevant malignancies, in addition to neurodegenerative diseases, exclusively the most prevalent Alzheimer’s disease. These age-dependent diseases are also impacted by immunocompromised conditions, including diabetes, obesity, and CVDs. Whereas a number of therapeutic approaches have evolved for countering a host of pathological processes during aging, preservation of hormonal balance is pivotal for sustaining several activities. Hence, the improvement of physical function and mobility and the restoration of hormone insufficiencies in continuously growing aging populations are pivotal for healthy aging and the quality of life of elderly women and men.
This Special Issue is aimed at publishing original research and review articles that address recent advances and understanding of fundamental, cellular, and molecular events involved in hormonal networks in aging, relevant diseases, and therapeutics.
Dr. Pulak R. Manna
Guest Editor
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Keywords
- hormonal imbalance and aging
- endocrinology
- physiology and pathophysiology
- steroidogenesis
- sex hormones and neurosteroids
- age-related complications and diseases
- tumorigenesis
- hormone-dependent cancers
- neurodegenrative diseases
- Alzheimer’s disease
- therapeutics
- healthy aging
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