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Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 50

Special Issue Editor


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Guest Editor
1. Servicio de Dermatología, Head of Hospitalization and Emergencies in Dermatology, Hospital Ramon y Cajal Madrid, Madrid, Spain
2. Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Madrid, Spain
Interests: cutaneous drug reactions; cutaneous lymphoma; dermatological emergencies; severe dermatological patient; erythroderma; cutaneous vasculitis; graft versus host disease; phototherapy; photobiology; phorpyrias
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Special Issue Information

Dear Colleagues,

Dermatology has undergone profound alterations over the last decade. Today, subspecialization is needed for the management of inflammatory and complex dermatosis, as remaining updated in all fields of dermatology is difficult. Furthermore, new target therapies are emerging along with the discovery of new paths and pathogenic mechanisms. Therefore, interaction with other medical specialties and multidisciplinary management is mandatory.

The new times in dermatology need to be open-minded and innovative in hospital practice. Coordination between researchers, diagnosis, and possible therapies undoubtedly will advance the work of physicians and benefit patients.

In this Special Issue, entitled “Dermatology: Advances in Pathophysiology and Therapies”, we aim to present this reality and a review of our experience working in coordination, adding a review of the relevant literature. We believe that it would be a very useful reference, and thus, we invite physicians working in the field of this novel concept to share their experience and submit their work for publication in the International Journal of Molecular Science. We hope to develop an amazing Special Issue capable of representing the modern era in medical dermatology.

Prof. Dr. Montserrat Fernández-Guarino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • immunodermatology
  • cutaneous lymphoma
  • cutaneous drug reaction
  • erythroderma
  • psoriasis
  • atopic dermatitis
  • eczematous reactions
  • cutaneous manifestation of systemic diseases
  • cutaneous vasculitis

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Published Papers (1 paper)

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Research

17 pages, 2400 KiB  
Article
Per- and Polyfluoroalkyl Substance-Induced Skin Barrier Disruption and the Potential Role of Calcitriol in Atopic Dermatitis
by JinKyeong Kim, SoYeon Yu, JeongHyeop Choo, HyeonYeong Lee and Seung Yong Hwang
Int. J. Mol. Sci. 2025, 26(15), 7085; https://doi.org/10.3390/ijms26157085 - 23 Jul 2025
Abstract
Environmental exposure to per- and polyfluoroalkyl substances (PFASs) has been increasingly associated with skin disorders, including atopic dermatitis (AD); however, the underlying molecular mechanisms remain unclear. This study aimed to evaluate the effects of perfluorononanoic acid (PFNA) and perfluorooctanoic acid (PFOA)—two widely detected [...] Read more.
Environmental exposure to per- and polyfluoroalkyl substances (PFASs) has been increasingly associated with skin disorders, including atopic dermatitis (AD); however, the underlying molecular mechanisms remain unclear. This study aimed to evaluate the effects of perfluorononanoic acid (PFNA) and perfluorooctanoic acid (PFOA)—two widely detected PFASs—on epidermal function and gene expression in Human Epithelial Keratinocyte, neonatal (HEKn). We assessed cell viability, morphology, and transcriptomic changes using in vitro assays and RNA-seq analysis from a neonatal cohort. PFASs induced dose-dependent cytotoxicity and downregulation of barrier-related genes. Ingenuity pathway analysis identified calcitriol as a suppressed upstream regulator. Functional validation revealed that calcitriol partially reversed the PFAS-induced suppression of antimicrobial peptide genes. These findings support the hypothesis that PFASs may contribute to AD-like skin pathology by impairing vitamin D receptor signaling and antimicrobial defense, and calcitriol demonstrates potential as a protective modulator. This study provides mechanistic insights into the impact of environmental toxicants on skin homeostasis and suggests a potential protective role for calcitriol in PFAS-induced skin barrier damage. Full article
(This article belongs to the Special Issue Dermatology: Advances in Pathophysiology and Therapies (3rd Edition))
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