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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Psychedelics and Mental Disorders: From Molecular Mechanisms to Therapies Potential

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 31 Jan 2027 | 2 articles | Viewed by 11209 | Submission Open

Keywords: psychedelics; drug-induced neurotoxicity; therapeutic potential; mental disorders; neuroprotective mechanisms; adult neurogenesis

(This special issue belongs to the Section Molecular Neurobiology)

Bone Metabolism and Bone Diseases

edited by

Giacomina Brunetti

submission deadline 31 Jan 2027 | 6 articles | Viewed by 10836 | Submission Open

Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease

edited by

Consolato M. Sergi

submission deadline 31 Jan 2027 | 2 articles | Viewed by 9137 | Submission Open

Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomolecular Structure, Function and Interactions: 2nd Edition

edited by

Ivo Crnolatac

submission deadline 31 Jan 2027 | 6 articles | Viewed by 8843 | Submission Open

Keywords: biophysical chemistry; protein–protein interactions; protein–DNA interactions; protein–ligand interactions; receptor–ligand interactions; biomolecular structure and function; protein folding and stability

(This special issue belongs to the Section Biochemistry)

Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy

edited by

Mariusz Chabowski

submission deadline 31 Jan 2027 | 6 articles | Viewed by 8594 | Submission Open

Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Pathogen Interactions: 3rd Edition

edited by

Sixue Chen

submission deadline 31 Jan 2027 | 2 articles | Viewed by 8318 | Submission Open

Keywords: pathogenicity; plant immunity; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); effectors; avirulent; virulent; biotroph; necrotrophy; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Compounds in Cancer Therapy: Molecular Mechanisms and Translational Potential

edited by

Gregory Christodoulidis

submission deadline 31 Jan 2027 | 2 articles | Viewed by 8000 | Submission Open

Keywords: natural compounds; cancer research; oxidative stress

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap

edited by

Oliver Seifert

submission deadline 31 Jan 2027 | 3 articles | Viewed by 7898 | Submission Open

Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers

(This special issue belongs to the Section Molecular Biology)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases—3rd Edition

edited by

Yasemin M. Akay

submission deadline 31 Jan 2027 | 1 articles | Viewed by 7448 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Toxicology Research: Understanding and Predicting Compound-Induced Toxicity

edited by

Miriam Beatríz Virgolini

submission deadline 31 Jan 2027 | 5 articles | Viewed by 7255 | Submission Open

Keywords: toxicity; adverse-outcome pathway; metals; pesticides; drugs of abuse; pharmaceuticals

(This special issue belongs to the Section Molecular Toxicology)

Bioactive Compounds and Their Antioxidant Role: 2nd Edition

edited by Tamara Jurina

submission deadline 31 Jan 2027 | 5 articles | Viewed by 7219 | Submission Open

Keywords: bioactive compounds; antioxidants; polyphenolic compounds; nutraceuticals; phytochemicals; bioavailability; medicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications

edited by

Ariel Fernando Castro

submission deadline 31 Jan 2027 | 4 articles | Viewed by 7198 | Submission Open

Keywords: oncogenes; tumor suppressors; cancer biology; molecular mechanisms; tumor microenvironment; biomarkers; targeted cancer therapy; cancer initiation and progression

(This special issue belongs to the Section Molecular Oncology)

Immune Regulation During Pregnancy

edited by Sabrina Marie Scroggins

submission deadline 31 Jan 2027 | 5 articles | Viewed by 7150 | Submission Open

Keywords: maternal–fetal immunology; multiomics in pregnancy; in utero inflammation; therapeutics; placental biology; neurodevelopment; gestational disorders; epigenetics; microbiome

(This special issue belongs to the Section Molecular Immunology)

Natural Products and Drug Delivery Systems in Dental Diseases

edited by

Rafael Scaf De Molon

submission deadline 31 Jan 2027 | 3 articles | Viewed by 7109 | Submission Open

Keywords: periodontitis; natural products; anti-inflammatory therapy; local drug delivery; gingival inflammation; regenerative periodontics; nanotechnology in dentistry; herbal medicine; antimicrobial agents; oral microbiome modulation; signaling pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Pathology and Treatment of Breast Cancer

edited by

Nabil Ismaili

submission deadline 31 Jan 2027 | 2 articles | Viewed by 7066 | Submission Open

Keywords: breast cancer; molecular pathology; precision medicine; antibody-drug conjugates (ADCs); circulating tumor DNA (ctDNA); targeted therapy; immunotherapy; treatment resistance; oligometastatic disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Regenerative Medicine Research

edited by

Rosa V. Ventrella

submission deadline 31 Jan 2027 | 4 articles | Viewed by 6958 | Submission Open

Keywords: regenerative medicine; tissue repair; wound healing; stem cells; cell differentiation; cell signalling; gene regulation; mechanotransduction; precision medicine

(This special issue belongs to the Section Molecular Biology)

Research on System Biology Methods and Tools for Integrating Omics Data

edited by Yuanyan Xiong

submission deadline 31 Jan 2027 | 4 articles | Viewed by 6954 | Submission Open

Keywords: systems biology; multi-omics integration; network analysis; computational biology; bioinformatics tools; machine learning; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI

edited by

Yuriy L. Orlov

and

Ming Chen

submission deadline 31 Jan 2027 | 3 articles | Viewed by 6848 | Submission Open

Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant–pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants

(This special issue belongs to the Section Molecular Informatics)

Steroids in Human Disease and Health

edited by

Martin Hill

submission deadline 31 Jan 2027 | 6 articles | Viewed by 6818 | Submission Open

Keywords: steroid metabolism; steroids and endocrinopathies; steroids and inflammation; corticosteroids; mineralocorticoids; neuroactive steroids; steroids and neuropsychiatric diseases; steroids and reproduction; steroidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Anticancer, Anti-Inflammatory and Antioxidant Properties of Active Substance and Natural Products

edited by Emira D’Amico

submission deadline 31 Jan 2027 | 8 articles | Viewed by 6446 | Submission Open

Keywords: anticancer activity; anti-inflammatory activity; oxidative stress; immunomodulation; drug discovery; natural products; active substance; plant extracts; phytochemicals

(This special issue belongs to the Section Molecular Biology)

Non-Coding RNAs’ Functionality—Diagnosis and Therapy in Cancer and Other Indications (2nd Edition)

edited by

Mohamed Raafat El-Gewely

submission deadline 31 Jan 2027 | 3 articles | Viewed by 6046 | Submission Open

Keywords: non-coding RNAs (ncRNAs); long non-coding RNAs (lncRNAs); MicroRNAs (miRNAs); circular RNAs (circRNAs); epigenetic and post-transcriptional regulation; epithelial–mesenchymal transition (EMT); cell proliferation and Apoptosis; biomarkers and Liquid biopsy; RNA-based therapeutics; next-generation sequencing (NGS); CRISPR/Cas9 screening; single-cell RNA sequencing (scRNA-seq); RNA interference (RNAi); cancer stem cells; early cancer diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

mRNA/miRNAs Network in Diabetes and Its Complications

edited by

Daniela Lixandru

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5867 | Submission Open

Keywords: RNA/miRNAs; exosomes; regenerative medicine; translational medicine; adipose tissue biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Retinal Diseases: 3rd Edition

edited by Minzhong Yu

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5839 | Submission Open

Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cells; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Heart Failure: From Pathogenesis to Innovative Treatments

edited by Volker Adams and

Ephraim Bernhard Winzer

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5581 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Venom and Antivenom

edited by

Vance G. Nielsen

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5533 | Submission Open

Keywords: venom; antivenom; mass spectroscopy; spectrophotometry; thromboelastography; coagulation; neuromuscular junction

(This special issue belongs to the Section Molecular Toxicology)

Research Progress in Cellular Senescence in Health and Disease

edited by

Gabriella Teti

and Mirella Falconi

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5467 | Submission Open

Keywords: senotherapy; cellular senescence; physiological relations; pathological relations; cell biology in aging; age-related diseases; senescence in mesenchymal stroma cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MHELTHERA: Targeted Molecular Radio-Immuno-Theranostics in Cancer and Beyond—in Honor of Prof. Dr. Otmar Dieter Wiestler

edited by Michael Philipp Bachmann and Holger Stephan

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5430 | Submission Open

Keywords: molecular diagnostics; radiotherapy; immunotherapy; endoradionuclide therapy; radiodiagnostics; radio-immuno-theranostics; radionuclides; PET/SPECT imaging; nanomaterials; chelators; chimeric antigen receptors (CARs); adapter CAR T cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Primary Colorectal Cancer and Liver Metastases

edited by Alexandros E. Giakoustidis

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5386 | Submission Open

Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Lipoprotein in Cardiovascular Disease

edited by

Joan Carles Vallvé

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5272 | Submission Open

Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: From Molecular Pathology to Therapeutic Approaches, 2nd Edition

edited by

Michael Eccles

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5238 | Submission Open

Keywords: melanoma; pathology; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular and Cellular Pathophysiologic Mechanisms Underlying Ocular Diseases and Emerging Therapies (2nd Edition)

edited by

Snježana Kaštelan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 5234 | Submission Open

Keywords: eye disease; immunobiological features; molecular pathogenesis; biomarkers; clinical implications; emerging therapies; lacrimal gland; ocular tumors; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Chemotherapeutic Agents in Cancer Treatment

edited by

Eleni Stamoula

submission deadline 31 Jan 2027 | 1 articles | Viewed by 5079 | Submission Open

Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics

(This special issue belongs to the Section Molecular Pharmacology)

Cancer-Associated Stromal Cells

edited by Krisztián Németh and Balazs Mayer

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5019 | Submission Open

Keywords: cancer; microenvironment; tumor-associated stromal cells; cancer-associated fibroblast; mesenchymal stem cell; tumor-associated adipocyte; pericyte; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR T cells; immunotherapy; signal transduction; small molecules

(This special issue belongs to the Section Molecular Oncology)

Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML

edited by

Albrecht Reichle

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4980 | Submission Open

Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine, decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML

(This special issue belongs to the Section Molecular Oncology)

Extracellular Vesicles: Advances in Multi-Omics

edited by

Leo Kei Iwai

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4962 | Submission Open

Keywords: extracellular vesicles; omics; mass spectrometry; molecular targets; biomarker

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence

edited by

Nuno Taveira

and Inês Bártolo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4928 | Submission Open

Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus–host interactions; HIV eradication strategies

(This special issue belongs to the Section Molecular Biology)

The Role of Gut Microbiome Regulation in Immunity and Inflammation

edited by Lei Deng

submission deadline 31 Jan 2027 | 5 articles | Viewed by 4904 | Submission Open

Keywords: gut microbiome; adaptive immunity; IBD; inflammation; innate immunity; enteric infections; salmonella; intestine barrier; mucosal immunity

(This special issue belongs to the Section Molecular Microbiology)

Targeting Cancer Metabolism: From Mechanism to Therapies

edited by

Zisis Kozlakidis

submission deadline 31 Jan 2027 | 4 articles | Viewed by 4657 | Submission Open

Keywords: cancer metabolism; metabolic alterations; Warburg effect; metabolic reprogramming; metabolic disorder; mitochondrial dysfunction; mitochondrial dynamics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Strategies and Molecular Insights Into Wound Healing

edited by

Cheong Hoon Seo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4367 | Submission Open

Keywords: wound healing; tissue regeneration; hypertrophic scar; biomaterials; stem cell therapy; gene therapy; exosomes; burn rehabilitation; inflammation; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Strategies Targeting Solid Tumors and the Tumor Microenvironment

edited by Emanuela Berrino and

Giuseppina Catanzaro

submission deadline 31 Jan 2027 | 4 articles | Viewed by 4345 | Submission Open

Keywords: cancer; tumor microenvironment; medicinal chemistry; drug design; structure–activity relationships; nanotechnologies; antibody–drug conjugates; non-coding RNAs; epigenetic

(This special issue belongs to the Section Molecular Oncology)

Endometriosis: Current Trends and Research Developments

edited by

Sylvia Mechsner

and

Renata Voltolini Velho

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4291 | Submission Open

Keywords: endometriosis; molecular mechanisms; pathophysiology; hormonal regulation; immune response; epigenetics; inflammation; biomarkers; transcriptomics; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cell Death in Human Diseases: Mechanisms, Biomarkers and Therapeutic Opportunities

edited by

Decha Pinkaew

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4223 | Submission Open

Keywords: cell death; apoptosis; necroptosis; ferroptosis; pyroptosis; human disease; biomarkers

(This special issue belongs to the Section Molecular Biology)

Role of Mesenchymal Stem/Stromal Cells (MSCs) in Human Diseases and Their Treatment

edited by

Mirjana Jerkic

submission deadline 31 Jan 2027 | 4 articles | Viewed by 4105 | Submission Open

Keywords: mesenchymal stem/stromal cells (MSCs); MSC homing; MSC properties; immune cells; macrophages; injury; inflammation; cell therapy

(This special issue belongs to the Section Molecular Immunology)

Advances in Alzheimer’s Disease

edited by

Giulia Bivona

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4069 | Submission Open

Keywords: Alzheimer’s Disease; amyloid beta; molecular target

(This special issue belongs to the Section Molecular Neurobiology)

Current Progress in Neutrophil Extracellular Traps (NETs)

edited by

Joanna Czerwińska

submission deadline 31 Jan 2027 | 1 articles | Viewed by 4047 | Submission Open

Keywords: PAD4; NETs; autoimmune diseases; CECNs; autoantibodies

(This special issue belongs to the Section Molecular Immunology)

Metabolomics of Medicinal Plants

edited by

L. Gerardo Zepeda Vallejo

and

Elvia Becerra-Martínez

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3971 | Submission Open

Keywords: metabolomics; medicinal plants; nuclear magnetic resonance; mass spectrometry; bioinformatic; phenotyping; metabolic pathways; bioactive metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Targeted Peptide Drugs for Metabolic Diseases

edited by

Lukasz Buldak

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3949 | Submission Open

Keywords: metabolic disorders; peptide drugs; MASLD; receptor targeting; lipid regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

DNA, Chromatin and Genome Structure

edited by Myakishev-Rempel Max and

Alexandre Vetcher

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3843 | Submission Open

Keywords: DNA structure and dynamics; non-B DNA structures (G-quadruplexes, Z-DNA); DNA topology; R-loops; RNA-DNA triplexes; extrachromosomal DNA (eccDNA); chromatin conformation (Hi-C, Micro-C, 3C); chromatin compaction; TADs and chromatin loops; three-dimensional genome organization; transcription regulation; gene regulation; DNA replication; DNA repair; transposable elements; chromosomal rearrangements; epigenetics; molecular modeling of DNA; molecular modeling of DNA hydration; molecular modeling of chromatin; telomeres; centromeres; introns; noncoding DNA

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds in Cancers: Second Edition

edited by

Patrícia M. A. Silva

Hassan Bousbaa

and

Honorina Cidade

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3652 | Submission Open

Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Brain Stroke Across the Lifespan: Mechanisms, Models, Translational Advances and Impacts Beyond the Brain

edited by

Gabriele Deidda

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3630 | Submission Open

Keywords: stroke; brain; cerebral injury; post-stroke recovery; systemic physiology; models; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 2101-2150 on page 43 of 61.

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