The Role of Lipoprotein in Cardiovascular Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 August 2025 | Viewed by 61
Special Issue Editor
Interests: rheumatoid arthritis; cardiovascular risk; microRNAs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipoproteins play a pivotal role in the transport of lipids throughout the bloodstream, ensuring cellular homeostasis and energy supply. However, alterations in their composition, structure, and function have been closely associated with the development and progression of cardiovascular diseases, including atherosclerosis, coronary artery disease, and myocardial infarction. Beyond traditional lipid profiles, recent research has highlighted the importance of lipoprotein subtypes, particle size, and functionality as key factors influencing cardiovascular risk, with emerging evidence also pointing to the role of triglyceride-rich lipoproteins and their remnants, and lipoprotein(s) as a key contributor to residual cardiovascular risk.
At the molecular level, multiple mechanisms link lipoproteins to cardiovascular disease. Oxidized low-density lipoprotein promotes foam cell formation and chronic inflammation, while small, dense LDL particles contribute to oxidative stress and endothelial dysfunction, impairing nitric oxide bioavailability and favoring vascular injury. Lipoprotein(s) enhances thrombogenesis by interfering with fibrinolysis, whereas dysfunctional HDL loses its protective role, compromising reverse cholesterol transport and acquiring pro-inflammatory properties. These and other molecular alterations create a pro-atherogenic environment that fosters plaque progression, destabilization, and increased cardiovascular risk.
This Special Issue, entitled "The Role of Lipoprotein in Cardiovascular Disease", aims to gather cutting-edge research and comprehensive reviews that delve into the molecular mechanisms by which lipoproteins contribute to cardiovascular diseases. We invite the submission of original studies exploring the structure–function relationships of different lipoprotein classes, their metabolic pathways, and their role as diagnostic biomarkers or therapeutic targets. Special interest will be paid to investigations employing advanced molecular techniques, including lipidomics and proteomics, to characterize lipoprotein composition and functionality. Additionally, studies addressing innovative therapeutic approaches aimed at modulating lipoprotein metabolism to reduce cardiovascular risk are highly encouraged. We welcome the submission of both basic and translational research that expands our understanding of lipoproteins and their implications in cardiovascular health and disease.
Dr. Joan Carles Vallvé
Guest Editor
Manuscript Submission Information
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Keywords
- lipoprotein
- cardiovascular disease
- atherosclerosis
- lipid metabolism
- HDL
- LDL
- VLDL
- Lp(a)
- TRLs
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