Natural Products and Drug Delivery Systems in Dental Diseases

Dear Colleagues,

Periodontal diseases, including gingivitis and periodontitis, are among the most prevalent chronic inflammatory conditions affecting humans, with significant implications for oral and systemic health. Periodontitis, in particular, leads to the progressive destruction of the supporting structures of the teeth and is associated with systemic conditions such as diabetes, cardiovascular disease, and rheumatoid arthritis. Conventional periodontal therapies, while effective in controlling infection, often fall short in achieving complete resolution of inflammation or regeneration of periodontal tissues.

Small molecules, biologics, and natural compounds, especially those derived from medicinal plants that have the potential to modulate key signaling pathways, have emerged as promising adjuncts or alternatives in periodontal therapy due to their anti-inflammatory, antimicrobial, antioxidant, and tissue-regenerative properties. Concurrently, advancements in drug-delivery systems have enabled targeted and sustained release of therapeutic agents directly into periodontal pockets, enhancing clinical outcomes while minimizing systemic side effects.

This Special Issue invites contributions exploring the integration of natural compounds, biologics, small molecules or other adjunctive therapies, and innovative drug-delivery technologies in the management of periodontitis and related conditions. We welcome original research, systematic and narrative reviews, brief reviews, and translational studies that address new therapeutic strategies, mechanisms of action, signaling pathways, and clinical applications, with the goal of advancing personalized and effective approaches for periodontal care.

Dr. Rafael Scaf De Molon
Guest Editor

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