Heart Failure: From Pathogenesis to Innovative Treatments
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 May 2026 | Viewed by 3421
Special Issue Editors
Interests: heart failure; skeletal muscle biology; endothelial function
Special Issue Information
Dear Colleagues,
Heart failure is still an epidemic disease affecting about 1% to 2% of the population worldwide. About half of the patients present with reduced left ventricular ejection fraction (LVEF). In the other half LVEF is preserved. Underlying pathogenesis and subsequently the efficacy of treatment approaches differ in these patient populations. Despite molecular and structural alterations in the myocardium, also peripheral organs like the skeletal muscle and the diaphragm exhibit molecular changes associated with muscle dysfunction and atrophy. The ultimate goal of understanding the pathology is to improve prevention strategies and treatment options for heart failure patients. In recent years, several molecular studies helped to unravel pathophysiological aspects and new treatment options for heart failure and related comorbidities.
We encourage submission of original full research papers as well as review articles dealing with novel mechanistic insights and details of molecular alterations in heart failure. We also encourage submission of manuscripts that focus on translating basic molecular knowledge to new medical applications in heart failure. Articles reporting novel technologies aimed at identifying disease biomarkers are also welcomed.
Topics include, but are not limited to, the following:
- New insights in the molecular mechanisms of heart failure, not only limited to the myocardium itself
- New molecular biomarkers and profiling of heart failure: discriminating between HFrEF and HFpEF, treatment stratification, and efficacy.
- Preclinical research that leads to novel therapies derived from molecular processes and cellular interactions, including gene therapy, nanomedicine-based therapies, and therapy based on small molecules.
- Clinical studies investigating treatment strategies for heart failure patients.
Prof. Dr. Volker Adams
Dr. Ephraim Bernhard Winzer
Guest Editors
Manuscript Submission Information
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Keywords
- heart failure
- HFrEF
- HFpEF
- comorbidities
- pathophysiology
- treatment
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