Molecular Advances in Primary Colorectal Cancer and Liver Metastases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 August 2025 | Viewed by 60
Special Issue Editor
Special Issue Information
Dear Colleagues,
We are delighted to announce the new Special Issue of the International Journal of Molecular Sciences, entitled “Molecular Advances in Primary Colorectal Cancer and Liver Metastases”.
Colorectal cancer (CRC) is the third most common type of carcinoma worldwide, with more than 1.9 million cases diagnosed during 2022. CRC is ranked as the second most common cause of cancer death, leading to more than 900,000 deaths per year, according to the World Health Organization (WHO). In 2020, CRC accounted for 10% of global cancer incidence and 9.4% of cancer deaths, with the worldwide prediction of 3.2 million new CRC cases arising in 2040. Additionally, approximately 70% of patients are prone to metastatic disease or relapse, including up to 50% of synchronous or metachronous liver metastases followed by lung metastasis. Among the genes responsible for CRC Ras, EGFR (Erb-B1), Erb-B2, TGF-alfa, TGF-beta 1 are included, with EREG leading to a higher prevalence of metastasis to the lungs.
The scope of this issue will include research on metastatic CRC patients and the latest advances in screening and diagnostic measures (molecular profiling, genetic and epigenetic alterations), as well as elaboration on the therapeutic advances and management. We are particularly interested in papers that bring light to long-lasting questions, highlight important issues, and report unexpected findings to the scientific and medical world. We are particularly interested in studies with a molecular basis, as the International Journal of Molecular Sciences is a journal of molecular science; pure clinical studies will not be suitable for our journal.
This Special Issue is supervised by Dr. Alexandros Giakoustidis and assisted by Ms. Sophia Tsokkou (Aristotle University of Thessaloniki).
Dr. Alexandros E. Giakoustidis
Guest Editor
Manuscript Submission Information
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Keywords
- colorectal cancer
- metastasis
- treatment
- management
- screening
- genetic alterations
- epigenetic alterations
- genomics
- epigenomics
- methylation
- liver-directed therapy
- radiation
- immunotherapy
- peritoneal carcinomatosis
- monotherapy
- chemotherapy
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