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Extracellular Vesicles: Advances in Multi-Omics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 October 2025 | Viewed by 458

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Laboratory of Applied Toxinology, Center of Toxins, Immune-Response and Cell Signaling LETA/CeTICS, Butantan Institute, São Paulo, Brazil
Interests: mass spectrometry-based proteomics; cancer; snake venom; scorpion venom; envenomation
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Special Issue Information

Dear Colleagues,

Extracellular vesicles (EVs) play a pivotal role in intercellular communication, determining physiological and pathological processes in diseases such as cancer, neurodegeneration, and cardiovascular disorders. Recent advances in multi-omics (proteomics, genomics, lipidomics, and metabolomics) have enhanced our understanding of EV biogenesis, cargo trafficking, and functional impact. Alongside these developments, cutting-edge isolation and characterization techniques, including high-resolution characterization by mass spectrometry, imaging, microfluidics, and AI-driven analytics, are accelerating EV research. This Special Issue of the International Journal of Molecular Sciences highlights the integration of multi-omic approaches with innovative methodologies to analyze EV-mediated signaling networks. Furthermore, we also emphasize translational potential, showcasing how EVs serve as biomarkers, therapeutic carriers, and regenerative therapy tools in clinical settings. We invite original research studies, reviews, and perspectives that connect basic science with clinical innovation, encouraging interdisciplinary collaboration. Together, we can drive progress in this dynamic field toward precision medicine and novel therapies.

Dr. Leo Kei Iwai
Guest Editor

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Keywords

  • extracellular vesicles
  • omics
  • mass spectrometry
  • molecular targets
  • biomarker

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Published Papers (1 paper)

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Review

33 pages, 4665 KiB  
Review
A Paradigm Shift in SSTI Management: The Multifunctional Role of Extracellular Vesicles
by Barathan Muttiah and Alfizah Hanafiah
Int. J. Mol. Sci. 2025, 26(13), 6481; https://doi.org/10.3390/ijms26136481 - 5 Jul 2025
Viewed by 353
Abstract
Skin and soft tissue infections (SSTIs) are becoming an urgent public health issue worldwide. The globe is facing a growing problem with drug-resistant germs, and current treatments are not quite cutting it. There is a real need for new therapies that can tackle [...] Read more.
Skin and soft tissue infections (SSTIs) are becoming an urgent public health issue worldwide. The globe is facing a growing problem with drug-resistant germs, and current treatments are not quite cutting it. There is a real need for new therapies that can tackle these challenges more effectively. This brings us to an interesting question: Can extracellular vesicles (EVs) from different sources, such as mesenchymal stem cells (MSCs), immune cells, or even plants and animals, help in treating SSTIs, especially given the rise in drug resistance? Studies have shown that MSC-derived EVs are particularly noteworthy because they carry components such as antimicrobial peptides (AMPs) that can work together to fight infections, boost the immune response, and aid in healing. These vesicles play a role in how our body interacts with infections, helping to clear bacteria, reduce inflammation, and promote tissue repair. We also see that EVs from plants and bacteria can directly fight off germs, while those from animals can support the healing process of skin. Although early studies have shown promise for EV therapies, there are still hurdles to overcome, such as ensuring consistent production and delivery. This review looks at the potential of EVs as powerful agents in managing infections and supporting healing, highlighting an exciting area of research in medicine. Full article
(This article belongs to the Special Issue Extracellular Vesicles: Advances in Multi-Omics)
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