Immune Regulation During Pregnancy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 28 August 2025 | Viewed by 31
Special Issue Editor
Interests: T cell-dendritic cell interactions; maternal-fetal immune adaptations; hypertensive disorders; neuroinflammation; microchimerism and immune programming across the lifespan; single cell spatial and multiomics; next-generation immunotherapies; autoimmunity; pathogen responses
Special Issue Information
Dear Colleagues,
Increasing evidence highlights the crucial role of inflammation in pregnancy, influencing maternal and fetal health through complex immune interactions and molecular pathways. Recent studies indicate that dysregulated inflammatory responses contribute to various pregnancy complications, including preeclampsia, preterm birth, and fetal growth restriction, with potential long-term effects on maternal and offspring health, such as cardiovascular, renal, and neurocognitive disorders. Advances in multiomic technologies, including genomics, transcriptomics, proteomics, and metabolomics, have provided new insights into the mechanisms underlying these conditions. The maternal–fetal interface, a key site of immune crosstalk, is now being explored through single-cell and spatial technologies, uncovering dynamic interactions that shape pregnancy outcomes. Moreover, epigenetic modifications and microbiome alterations have emerged as critical regulators of fetal programming, linking maternal immune status to offspring disease susceptibility. This Special Issue will focus on the molecular mechanisms behind, as well as multiomic insights into, pregnancy-induced inflammation, welcoming studies that explore inflammatory pathways, immune regulation, and precision medicine approaches aimed at mitigating pregnancy-related complications.
Dr. Sabrina Marie Scroggins
Guest Editor
Manuscript Submission Information
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Keywords
- maternal–fetal immunology
- multiomics in pregnancy
- in utero inflammation
- therapeutics
- placental biology
- neurodevelopment
- gestational disorders
- epigenetics
- microbiome
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