Targeted Peptide Drugs for Metabolic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 40
Special Issue Editor
Interests: internal medicine; endocrinology; clinical pharmacology; obesity; metabolic diseases; hyperlipidemia; diabetes; arterial hypertension
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, we have witnessed the development of a plethora of novel peptide- and protein-based pharmacotherapies for the treatment of metabolic diseases. The crown jewels appear to be GLP-1 analogues, which are used in the treatment of obesity and type 2 diabetes, and have been shown to improve symptoms in MASLD. Furthermore, the improved availability of therapeutic options for other metabolic diseases has come under the spotlight (e.g., romosozumab for osteoporosis, the growth hormone antagonist pegvisomant, and the PTH analogue palopegteriparatide). Various novel targets and innovative compounds are on the brink of being introduced in clinical contexts.
Therefore, I am pleased to invite you, fellow researchers, to a Special Issue focused on targeted peptide drugs for metabolic diseases. Submitted manuscripts should explore advances in peptide-based interventions for key metabolic disorders, including (but not exclusively) the following:
- Obesity;
- Metabolic dysfunction-associated steatotic liver disease (MASLD);
- Liver steatosis and fibrosis;
- Atherosclerosis;
- Hyperlipidemia;
- Elevated lipoprotein(a) [Lp(a)] levels;
- Hyperuricemia;
- Type 2 diabetes mellitus;
- Osteoporosis;
- Acromegaly.
In this particular collection, major emphasis will be put on a pharmacotherapeutic approach in a variety of models, including in vitro and in vivo settings. Studies on the therapeutic modulation of metabolic pathways using precision peptide strategies would be of the utmost interest, and distinct attention will be given to emerging data on receptor targeting, lipid regulation, and inflammation resolution.
I look forward to your participation!
Dr. Lukasz Buldak
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolic disorders
- peptide drugs
- MASLD
- receptor targeting
- lipid regulation
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