Cancer-Associated Stromal Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 15
Special Issue Editors
Interests: mesenchymal stem cells; cancer; microenvironment; tumor-associated stromal cells; cancer-associated fibroblast; mesenchymal stem cell; tumor-associated adipocyte; pericyte; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR T cells; immunotherapy; signal transduction; small molecules
Special Issues, Collections and Topics in MDPI journals
Interests: hematopoietic stem cells; mesenchymal stem cells; genodermatoses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The cancer microenvironment consists of several unique cell types including endothelial cells, various immune cells, and tumor-associated stromal cells (TASCs) which are comprised of cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), tumor-associated adipocytes (TAA) and pericytes. The role of TASCs is complex and has been linked to tumor initiation, tumor growth, angiogenesis, metastasis, and therapy resistance. In this Special Issue we invite original research articles and reviews that report on novel roles of TASCs in tumor biology including interactions with cancer cells, endothelial cells and immune cells. We welcome research that nvestigates the intersection of TASCs with extracellular matrix (ECM) remodeling, extracellular vesicles, tumor hypoxia, and metabolic crosstalk. Cutting-edge studies employing single-cell and spatial transcriptomics, proteomics, and in-silico modeling are highly encouraged. We are also seeking to publish studies that identify unique molecular pathways (cytokines, small molecules, signal transduction pathways etc) that govern TASCs interactions with other cell types and may be targeted to combat cancer growth and induce anti-cancer immunity. Research that highlights the importance of TASCs in targeted cancer-therapies, checkpoint-inhibitor-based immunotherapies and CAR-T cell therapies are especially welcomed.
Dr. Krisztián Németh
Dr. Balazs Mayer
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- microenvironment
- tumor-associated stromal cells
- cancer-associated fibroblast
- mesenchymal stem cell
- tumor-associated adipocyte
- pericyte
- cancer immunology
- angiogenesis
- metastasis
- targeted cancer therapy
- checkpoint inhibitor
- CAR T cells
- immunotherapy
- signal transduction
- small molecules
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