Translationally Controlled Tumor Protein (TCTP) in Human Health and Disease: From Bench to Bedside
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 224
Special Issue Editor
Special Issue Information
Dear Colleagues,
TCTP—also known as Translationally Controlled Tumor Protein (TCTP), Histamine Releasing Factor (HRF), and Fortilin—is a highly conserved, multifunctional protein essential for cellular homeostasis. Initially identified as a growth-associated protein, TCTP is now recognized for its critical roles in cell proliferation, survival, immune modulation, and stress response pathways. Ubiquitously expressed across tissues, it has emerged as a key player in the onset and progression of numerous human diseases, including cancer, allergic inflammation, cardiovascular disorders, and metabolic conditions.
In oncology, TCTP contributes to tumor progression, apoptosis resistance, and chemoresistance. As HRF, it modulates immune responses and is implicated in allergy and autoimmune disorders. Its interactions with major signaling networks—such as p53, Bcl-2, and others—position TCTP as a central regulatory hub in both physiological and pathological contexts.
Despite its broad biological relevance, many aspects of TCTP’s function remain incompletely understood. This Special Issue aims to highlight recent advances and stimulate further investigation into its molecular mechanisms, clinical implications, and translational potential as both a biomarker and therapeutic target.
We invite original research articles and comprehensive reviews that explore the molecular mechanisms, pathophysiological relevance, and therapeutic potential of TCTP. Topics of interest include, but are not limited to the following:
- TCTP in cancer progression, metastasis, and therapy resistance;
- Apoptosis regulation and stress response pathways;
- Roles in inflammation, allergy, and autoimmune diseases;
- Cardiovascular, metabolic, and neurodegenerative roles;
- Diagnostic and prognostic biomarker applications;
- Targeting strategies: small molecules, RNA-based therapies, and antibodies;
- Structural biology and protein interaction networks.
We look forward to your contributions to this timely and impactful issue.
Dr. Decha Pinkaew
Guest Editor
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Keywords
- TCTP
- fortilin
- histamine releasing factor
- human disease
- cancer
- inflammation and allergy
- cardiovascular
- therapeutic target
- biomarker discovery
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