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Bioactive Compounds and Their Antioxidant Role: 2nd Edition
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Bioactive Compounds and Their Antioxidant Role: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 771

Special Issue Editor

Dr. Tamara Jurina

E-Mail Website
Guest Editor
Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, Croatia
Interests: near-infrared spectroscopy; chemometrics; modelling; extraction; food quality
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to announce this Special Issue, “Bioactive Compounds and Their Antioxidant Role: 2nd Edition”, of the International Journal of Molecular Sciences. Bioactive compounds are intensively evaluated due to their positive impacts on human health due to their physiological, immunological and behavioural effects. These compounds are of great importance since they are involved in the regulation of various metabolic processes in the human body, such as free radical scavenging, gene expression, enzymes, etc. Besides their primary role in traditional medicine, they play an important role in numerous food and pharmaceutical industries due to increasing consumer demand for natural, healthy, nutritious and economical products. Key parameters such as the bioaccessibility, bioavailability and bioactivity of these compounds should be taken into account in order to ensure their proper application.

This Special Issue will include papers dealing with the extraction and identification of biocompounds from different natural sources; their application in the medicine, pharmacological, cosmetic and food industries; and, in combination with antioxidants and polyphenols, their uses under oxidative stress conditions.

Dr. Tamara Jurina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • antioxidants
  • polyphenolic compounds
  • nutraceuticals
  • phytochemicals
  • bioavailability
  • medicine

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Published Papers (2 papers)

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Research

21 pages, 2108 KB  
Article
Valorization of Carménère Grape Pomace: Extraction, Microencapsulation, and Evaluation of the Bioactivity of Polyphenols in Caco-2 Cells
by Paula Valenzuela-Bustamante, Paula Cornejo, Nicolás Nolan, Alina Concepción-Alvarez, Raquel Bridi, Miguel Ángel Rincón-Cervera, Omar Porras, Adriano Costa de Camargo and M. Fernanda Arias-Santé
Int. J. Mol. Sci. 2025, 26(16), 7994; https://doi.org/10.3390/ijms26167994 - 19 Aug 2025
Viewed by 261
Abstract
Grape pomace is a major by-product of winemaking and a rich source of phenolic compounds with antioxidant potential. The Carménère variety, emblematic of Chilean viticulture, remains underutilized despite its high anthocyanin and flavanol content. This study aimed to develop a cost-effective method to [...] Read more.
Grape pomace is a major by-product of winemaking and a rich source of phenolic compounds with antioxidant potential. The Carménère variety, emblematic of Chilean viticulture, remains underutilized despite its high anthocyanin and flavanol content. This study aimed to develop a cost-effective method to recover and stabilize bioactive compounds from Carménère grape pomace. Five extracts were obtained using ethanol–water mixtures (0–100%) and characterized by HPLC-DAD and antioxidant assays (DPPH, FRAP, ORAC-FL). The 80% ethanol extract (EET-80) showed the highest antioxidant capacity (FRAP: 2909.3 ± 37.6; ORAC-FL: 1864.3 ± 157.8 µmol TE/g dw) and was selected for microencapsulation via spray drying using maltodextrin. This scalable technique protects thermosensitive compounds and enhances their applicability. The optimized 1:50 extract-to-carrier ratio achieved high encapsulation efficiency (85.7 ± 0.7%). In Caco-2 cells, the microencapsulated extract (5–250 µg/mL) showed no alteration in metabolic activity and significantly reduced intracellular ROS levels (65% inhibition at 250 µg/mL). Solvent polarity selectively influenced polyphenol recovery—50% ethanol favored catechin (581.1 µg/g) and epicatechin (1788.3 µg/g), while 80% ethanol enhanced malvidin-3-O-glucoside (118.0 µg/g). These findings support the valorization of Carménère grape pomace as a sustainable source of antioxidants and highlight the role of microencapsulation in improving extract stability and functionality. Full article
(This article belongs to the Special Issue Bioactive Compounds and Their Antioxidant Role: 2nd Edition)
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19 pages, 3393 KB  
Article
Integrated Phytochemical Profiling, UPLC-HRMS Characterization, and Bioactivity Evaluation of Zingiber officinale and Piper nigrum
by Aicha Boubker, Abdelmoula El Ouardi, Taha El Kamli, Mohammed Kaicer, Faouzi Kichou, Khaoula Errafii, Adnane El Hamidi, Rachid Ben Aakame and Aicha Sifou
Int. J. Mol. Sci. 2025, 26(16), 7782; https://doi.org/10.3390/ijms26167782 - 12 Aug 2025
Viewed by 326
Abstract
The phytochemical profiles, antioxidant capacities, mineral composition, and antibacterial activities of Zingiber officinale (Z. officinal) and Piper nigrum (P. nigrum) were explored through aqueous, ethanolic, and methanolic extractions. The extracts were analyzed for polyphenols, flavonoids, and tannins, and their [...] Read more.
The phytochemical profiles, antioxidant capacities, mineral composition, and antibacterial activities of Zingiber officinale (Z. officinal) and Piper nigrum (P. nigrum) were explored through aqueous, ethanolic, and methanolic extractions. The extracts were analyzed for polyphenols, flavonoids, and tannins, and their antioxidant potential was assessed using the DPPH assay. UPLC-HRMS identified major bioactive compounds, including 6-gingerol and shogaol in Z. officinale, and piperine and piperlonguminine in P. nigrum. Mineral analysis showed that P. nigrum was particularly rich in essential elements, including calcium (Ca), magnesium (Mg), and iron (Fe). In antibacterial testing, P. nigrum demonstrated wider zones of inhibition against E. coli, whereas Z. officinale was more active at lower concentrations, showing MICs as low as 3.91 µg/mL against Salmonella and S. aureus. PCA analysis revealed strong correlations between phenolic content and biological effects. These results underscore the potential of both spices as effective natural agents for use in food preservation and health-promoting applications. Full article
(This article belongs to the Special Issue Bioactive Compounds and Their Antioxidant Role: 2nd Edition)
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