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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications

edited by

Ariel Fernando Castro

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2586 | Submission Open

Keywords: oncogenes; tumor suppressors; cancer biology; molecular mechanisms; tumor microenvironment; biomarkers; targeted cancer therapy; cancer initiation and progression

(This special issue belongs to the Section Molecular Oncology)

Steroids in Human Disease and Health

edited by

Martin Hill

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2523 | Submission Open

Keywords: steroid metabolism; steroids and endocrinopathies; steroids and inflammation; corticosteroids; mineralocorticoids; neuroactive steroids; steroids and neuropsychiatric diseases; steroids and reproduction; steroidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bioinformatics of Gene Regulations and Structure–2025

edited by

Yuriy L. Orlov

Anastasia Anashkina

and

Nikolay A. Kolchanov

submission deadline 30 Nov 2025 | 4 articles | Viewed by 2399 | Submission Open

Keywords: gene expression regulation; bioinformatics and systems biology; NGS data analysis of gene expression; ncRNA networks; computer genomics of model organisms; fundamental biomedicine model; regulatory gene networks; AI tools in bioinformatics

(This special issue belongs to the Section Molecular Informatics)

Impact of Circulatory and Blood Clotting Dysfunctions in Infectious Diseases

edited by

Hsin-Hou Chang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2379 | Submission Open

Keywords: infectious diseases; circulatory dysfunction; coagulation disorders; endothelial activation; platelet aggregation; anticoagulant therapy; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Study on Organellar Genomes of Vascular Plants

edited by

Monika Szczecińska

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2292 | Submission Open

Keywords: mitochondrial DNA (mtDNA); chloroplast DNA (cpDNA); plant evolution; plant organellar genome; genomics

(This special issue belongs to the Section Molecular Plant Sciences)

The Innate Immune System in Renal Diseases

edited by

Takashi Oda

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2285 | Submission Open

Keywords: innate immune system; acquired immunity; complement system; dendritic cells; monocyte/macrophages (Mϕ); polymorphonuclear leukocytes; NK/NKT cells; innate lymphoid cells (ILCs); AKI; CKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Venom and Antivenom

edited by

Vance G. Nielsen

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2008 | Submission Open

Keywords: venom; antivenom; mass spectroscopy; spectrophotometry; thromboelastography; coagulation; neuromuscular junction

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence

edited by

Nuno Taveira

and Inês Bártolo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1917 | Submission Open

Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus– host interactions; HIV eradication strategies

(This special issue belongs to the Section Molecular Biology)

State-of-the-Art Molecular Genetics and Genomics in Poland: 3rd Edition

edited by

Ewa Fiedorowicz

and

Anna Cieślińska

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1890 | Submission Open

Keywords: RNA; DNA; DNA structure; damage; and repair; post-translational modifications; autophagy; cell cycle; gene expression; functions and therapy; mutation; nuclear organization; polymerase; nucleic acid– protein interactions; molecular clone; sequencing analysis; epigenetics; transcriptomics; genetics of aging; genetic disorders; SNP; etc

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cellular and Molecular Mechanisms of Blood–Brain Barrier (BBB) Dysfunction and Dementia

edited by Mark Slevin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1861 | Submission Open

Keywords: blood– brain barrier; Alzheimer’ s disease; endothelial dysfunction; amyloid beta; tau; neuroinflammation; oxidative stress; aging; gut– brain axis; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Micro-RNA in Gastrointestinal Cancers—from Molecules to Novel Therapies

edited by

Jacek Baj

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1830 | Submission Open

Keywords: micro-RNA; gastrointestinal cancer; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; neuroendocrine tumor; esophageal cancer; gallbladder cancer; rectal cancer

(This special issue belongs to the Section Molecular Oncology)

Enhancing Stem Cell Grafting in Tissue Regeneration and Repair

edited by

Yuanyuan Zhang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1789 | Submission Open

Keywords: stem cell therapy; tissue regeneration; graft enhancement; molecular mechanisms; engraftment; biomaterials; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Highlights in Pathophysiology of the Musculoskeletal System, 3rd Edition

edited by

Marta Anna Szychlinska

Rosario Barone

and

Giovanna Calabrese

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1718 | Submission Open

Keywords: musculoskeletal; skeletal; tendon; ligament; intervertebral; articular cartilage; osteoarthritis; rheumatoid arthritis; sarcopenia; muscle wasting; osteoporosis; bone necrosis; synovium; pain; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Climate Change Mitigation Strategies in Grapevine Molecular, Biochemical, and Physiological Performance

edited by

Sandra Pereira

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1682 | Submission Open

Keywords: grapevine growth; climate change; abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Modeling: Latest Advances and Applications, 2nd Edition

edited by

Maria Alexandra Mernea

and

Dan Florin Mihǎilescu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1575 | Submission Open

Keywords: molecular modeling; computational chemistry; drug design; material science; biomolecular interactions; algorithmic advances; theoretical chemistry; simulation techniques; predictive modeling; interdisciplinary applications

(This special issue belongs to the Section Molecular Biophysics)

Mechanisms of Resistance to Melanoma Immunotherapy

edited by Marko B. Lens

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1556 | Submission Open

Keywords: melanoma; immune checkpoint inhibitors; PD-1

(This special issue belongs to the Section Molecular Oncology)

The Latest Development of Molecular Research in Animal Nutrition

edited by

Mohammad Moniruzzaman

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1523 | Submission Open

Keywords: animal nutrition; molecular biology; microbiome; feed efficiency; sustainable aquaculture; proteomics; metabolomics; molecular mechanisms; metabolic regulation; disease resistance

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Studies on Microbial Degradation of Emerging Pollutants Toxic to Human Health

edited by

Yang Yang

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1496 | Submission Open

Keywords: microbial degradation; emerging pollutants and organic pollutants; bacteria; fungi; enzyme

(This special issue belongs to the Section Molecular Microbiology)

Molecular Biology of Foodborne Pathogens: Pathogenesis and Control Strategies

edited by

Jaewoo Bai

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1474 | Submission Open

Keywords: foodborne pathogens; molecular pathogenesis; virulence factor; virulence genes; host– pathogen interaction; antimicrobial resistance; bioinformatics; omics technology; rapid detection and diagnostics; control strategies; food safety

(This special issue belongs to the Section Molecular Microbiology)

Structural Codes of Sphingolipids and Their Involvement in Diseases

edited by

Sandro Sonnino

and

Elena Chiricozzi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1254 | Submission Open

Keywords: sphingolipids; sphingolipid hydrophilic head; sphingolipid hydrophobic tail; sphingolipid signalling; sphingolipid diseases

(This special issue belongs to the Section Biochemistry)

Cyclic Nucleotide-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects

edited by

Jens Schlossmann

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1213 | Submission Open

Keywords: cyclic nucleotide; cNMP; cAMP; cGMP; cCMP; cUMP; cGAMP; signaling proteins; signal transduction pathways; scaffolds; nitric oxide; natriuretic peptides; adenylyl cyclases; guanylyl cyclases; kinases; phosphodiesterases; channels; (patho)physiology; pharmacology

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms Governing Lipid Metabolism in Health and Disease

edited by

Christina E. Kostara

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1175 | Submission Open

Keywords: lipidomics; lipid biomarkers; lipid metabolism; cardiovascular disease; cardiometabolic diseases; non-alcoholic fatty liver disease; diabetes; lipoproteins; NMR spectroscopy; mass spectrometry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

In Silico Approaches to Unravelling Toxicity Mechanisms in Molecular Drugs

edited by

Yoshihiro Uesawa

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1140 | Submission Open

Keywords: cheminformatics; in silico analysis; QSAR; toxicity prediction; machine learning; toxicity mechanisms; omics data integration; toxicity biomarkers; artificial intelligence; adverse event database

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research in Nanotechnology for Natural Products

edited by

Carmen Lizette Del Toro Sánchez

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1056 | Submission Open

Keywords: molecular nanotechnology; natural products; bioactive compounds; nanocarriers; targeted delivery; encapsulation; bioavailability; pharmacological applications; food applications; biomedical nanotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pathogenesis and Treatments of Head and Neck Cancer: 2nd Edition

edited by

Marko Tarle

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1026 | Submission Open

Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology

(This special issue belongs to the Section Molecular Oncology)

The Molecular and Cellular Pathophysiologic Mechanisms Underlying Ocular Diseases and Emerging Therapies (2nd Edition)

edited by

Snježana Kaštelan

submission deadline 30 Nov 2025 | 1 articles | Viewed by 996 | Submission Open

Keywords: eye disease; immunobiological features; molecular pathogenesis; biomarkers; clinical implications; emerging therapies; lacrimal gland; ocular tumors; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxicology Research: Understanding and Predicting Compound-Induced Toxicity

edited by

Miriam Beatríz Virgolini

submission deadline 30 Nov 2025 | 1 articles | Viewed by 977 | Submission Open

Keywords: toxicity; adverse-outcome pathway; metals; pesticides; drugs of abuse; pharmaceuticals

(This special issue belongs to the Section Molecular Toxicology)

Trace Elements, Metal Ions, Channels and Transporters in Metabolism

edited by

Maria Maares

submission deadline 30 Nov 2025 | 1 articles | Viewed by 975 | Submission Open

Keywords: cancer; cardiac dysfunction; enzyme function; metabolism; metal ions; neurologic disorders; pathophysiology; trace elements

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Supplements and Drug-Based Strategies in Neonatal and Paediatric Health

edited by

Giulia Malaguarnera

submission deadline 30 Nov 2025 | 1 articles | Viewed by 953 | Submission Open

Keywords: neonatal pharmacology; paediatric supplements; nutraceuticals in early life; microbiota– host interactions; infectious diseases in children; neurodevelopmental disorders; drug– nutrient interactions; dosing and delivery routes; molecular paediatrics; critical analysis of paediatric interventions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Targeting Epigenetic Complexes and Alternative Protein Degradation Pathways in Medicinal Chemistry

edited by Jean Leandro Dos Santos

submission deadline 30 Nov 2025 | 1 articles | Viewed by 938 | Submission Open

Keywords: protein degradation; LYTAC; AUTAC; ATTEC; epigenetics; NuRD; HDAC; BRD; SWI/SNF; PRC2; chromatin; conjugates; lysosome; autophagy; drug discovery

(This special issue belongs to the Section Biochemistry)

Molecular View of Natural Products with Antiviral Effects

edited by

Jin-ching Lee

submission deadline 30 Nov 2025 | 1 articles | Viewed by 859 | Submission Open

Keywords: virus; phytochemicals; nutritional supplements; marine extracts; antioxidants

(This special issue belongs to the Section Molecular Microbiology)

Protein–Protein Interactions in Human Cancer

edited by

Geng Wu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 853 | Submission Open

Keywords: protein– protein interactions; protein– protein complexes; human cancer; signal transduction pathways; protein structure and function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Environmental Pollutants Exposure and Toxicity

edited by

Tzveta Georgieva

submission deadline 30 Nov 2025 | 1 articles | Viewed by 842 | Submission Open

Keywords: environmental pollutants exposure assessment; molecular methods; biomarkers; human safety; environmental safety

(This special issue belongs to the Section Molecular Toxicology)

Molecular Signaling and Cellular Mechanisms in Asthma

edited by

Kapil Sirohi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 832 | Submission Open

Keywords: asthma; endotypes; pausi-immune asthma; nonatopic asthma; steroid insensitivity; neutrophilic asthma; innate lymphoid cells; Th2 cells

(This special issue belongs to the Section Molecular Immunology)

Analyzing the Molecular Mechanisms of Plant Disease Pathogenesis and Host Disease Resistance

edited by Zhibing Wu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 830 | Submission Open

Keywords: pathogenicity mechanisms; plant– pathogen interactions; plant immunity; effector biology; resistance genes; multi-omics approaches; nanotechnology in plant protection

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms in Mitochondria-Targeted Drug Delivery System

edited by

Maria Manuel Oliveira

and

Francisco Peixoto

submission deadline 30 Nov 2025 | Viewed by 829 | Submission Open

Keywords: mitochondria; mitochondrial diseases; nanoformulations; therapeutic agents; drug release; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Canonical and Noncanonical Inflammasomes in Inflammation and Diseases

edited by

Young-Su Yi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 769 | Submission Open

Keywords: canonical; noncanonical; inflammasome; inflammation; human diseases; anti-inflammatory therapeutics

(This special issue belongs to the Section Molecular Immunology)

Advances in Fluorescent Sensors

edited by

Levente Cseri

and

Ervin Kovács

submission deadline 30 Nov 2025 | 1 articles | Viewed by 698 | Submission Open

Keywords: fluorescence probe; fluorescent nanomaterials; analyte recognition; fluorescence imaging; real-time monitoring; photoinduced electron transfer; Fö rster resonance energy transfer; genetically encoded indicators; sensor devices; fluorescence microscopy

(This special issue belongs to the Section Materials Science)

Diversity in Structure, Function, and Regulation of Calcium-Permeable Channels

edited by

Lucie Parent

submission deadline 30 Nov 2025 | Viewed by 640 | Submission Open

Keywords: calcium-permeable channels in health and disease; calcium-permeable channels in calcium cycling; TRP channels; voltage-gated calcium channels; STIM / Orai complexes; intracellular IP3 calcium channels; intracellular RyR calcium channels; posttranslational calcium channel modifications; calcium-permeable channel inhibitors; calcium-permeable channel biophysics; calcium-permeable channel evolution

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications

edited by

Lidia Magerusan

submission deadline 30 Nov 2025 | 2 articles | Viewed by 624 | Submission Open

Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety

(This special issue belongs to the Section Molecular Microbiology)

Sarcomas: From Molecular Signatures to Morphologic Patterns

edited by

Isidro Machado

submission deadline 30 Nov 2025 | 1 articles | Viewed by 620 | Submission Open

Keywords: sarcomas; histopathology; molecular pathology; FISH; gene fusion in sarcomas

(This special issue belongs to the Section Molecular Oncology)

Molecular Aspects of Viral Pathogenesis: From Infection to Host Response

edited by

Quang Duy Trinh

submission deadline 30 Nov 2025 | 1 articles | Viewed by 618 | Submission Open

Keywords: viruses; viral pathogenesis; virus– host interaction; molecular virology; immunity; viral entry; viral replication; emerging viruses; infectious diseases; inflammation

(This special issue belongs to the Section Molecular Microbiology)

Oral Potentially Malignant Disorders and Oral Cancers: From Molecular Pathology to Therapeutic Approaches

edited by

Ana Caruntu

and Nicholas Kalavrezos

submission deadline 30 Nov 2025 | 1 articles | Viewed by 606 | Submission Open

Keywords: oral cancer; oral potentially malignant disorders; molecular mechanisms in oral cancer; detection of oral cancer; pathogenic mechanisms of oral cancer; immune system; translational oral cancer; microbiota oral cancer; therapy for oral cancer

(This special issue belongs to the Section Molecular Oncology)

Macrophage Polarization and Human Inflammatory Diseases

edited by

Mary Cloud B. Ammons

submission deadline 30 Nov 2025 | Viewed by 603 | Submission Open

Keywords: macrophage polarization; inflammation; metabolic immunomodulation; epigenetics; in vitro models; in vivo models; diagnostics; therapeutics; infectious disease; metabolic disease

(This special issue belongs to the Section Molecular Pharmacology)

Research in Genetic Causes of Adult-Onset Disorders

edited by

Claudio Graziano

submission deadline 30 Nov 2025 | Viewed by 593 | Submission Open

Keywords: ADPKD; cardiomyopathy; CADASIL; amyloidosis; MODY; late-onset hearing impairment; penetrance; adult onset

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Gastrointestinal Immunity: Balancing Homeostasis and Pathological States

edited by Mihai Danciu and Gabriel Becheanu

submission deadline 30 Nov 2025 | Viewed by 530 | Submission Open

Keywords: gastrointestinal immunity; mucosal barrier function; immune signaling pathways; gut microbiota; inflammatory bowel disease (IBD); colorectal cancer; cytokines and chemokines; immunopathology; targeted immunotherapy; biomarkers of gut inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Metal Nanoparticles

edited by

Emilia Konował

submission deadline 30 Nov 2025 | 1 articles | Viewed by 514 | Submission Open

Keywords: metal nanoparticles; molecular-level mechanisms; functional nanostructures; environmental nanotechnology; nanoparticle stability; catalysis; hybrid nanomaterials; bimetallic systems; ligand– nanoparticle interactions

(This special issue belongs to the Section Molecular Nanoscience)

Progress in Prevention and Treatment of Cardiovascular Diseases and Arrhythmias

edited by

Narcis Tribulova

submission deadline 30 Nov 2025 | 1 articles | Viewed by 459 | Submission Open

Keywords: translational research; novel animal models; novel treatment targets; pleiotropic drugs; harnessing of molecular H

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxicomicrobiomics: Exploring the Interplays Between Xenobiotics, Gut Microbiota, and Health

edited by