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Diversity in Structure, Function, and Regulation of Calcium-Permeable Channels

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 20

Special Issue Editor


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Guest Editor
Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada
Interests: voltage-gated calcium channels; cardiomyocytes. cardiac arrhythmias; regulation; protein–protein interactions; posttranslational modifications; electrophysiology; patch-clamp; structural biology

Special Issue Information

Dear Colleagues,

Calcium ions (Ca2+) significantly impact cellular life in eukaryotes, from the monocellular to the pluricellular organisms. Ca2+ plays crucial roles in excitability, exocytosis, motility, and transcription. Their movements are regulated by calcium-permeable channels that serve as a pathway to control the concentration of Ca2+ on each side of the phospholipid bilayer. These integral proteins form pores that are permeable to Ca2+. Calcium-permeable channels must balance the influx of Ca2+ and the efflux of Ca2+ to maintain a free submicromolar Ca2+ concentration in the cytoplasm. They come in many forms and display a wide range in structure, function, and regulation. Part of this diversity, but not all, arises from the variety in the nature and the number of subunits. They can be stimulated by a variety of stimuli, including, but not limited to, membrane depolarization, signaling molecules (both extracellular and intracellular), and physical forces such as stretch or temperature. Dysfunctional regulation of calcium-permeable channels is associated with a flurry of pathologies.

Prof. Dr. Lucie Parent
Guest Editor

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Keywords

  • calcium-permeable channels in health and disease
  • calcium-permeable channels in calcium cycling
  • TRP channels
  • voltage-gated calcium channels
  • STIM / Orai complexes
  • intracellular IP3 calcium channels
  • intracellular RyR calcium channels
  • posttranslational calcium channel modifications
  • calcium-permeable channel inhibitors
  • calcium-permeable channel biophysics
  • calcium-permeable channel evolution

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