Molecular Mechanisms of Gastrointestinal Immunity: Balancing Homeostasis and Pathological States
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 71
Special Issue Editor
Special Issue Information
Dear Colleagues,
The gastrointestinal immune system plays a pivotal role in maintaining the delicate balance between immune tolerance and immune activation in response to food antigens, microbiota, and invading pathogens. Disruption of this balance can result in chronic inflammation, barrier dysfunction, and the onset of a wide range of gastrointestinal pathologies, including inflammatory bowel disease, colorectal cancer, and infections. Recent advances have shed light on the complex molecular pathways involved in mucosal immunity, innate and adaptive immune responses, and their crosstalk with epithelial and stromal cells.
This Special Issue aims to explore the latest research on the molecular mechanisms governing gastrointestinal immunity, with a particular focus on how these mechanisms contribute to either the preservation of gut homeostasis or the development of pathological conditions. We welcome original research articles and comprehensive reviews addressing immune regulation, signaling pathways, host–microbe interactions, and novel therapeutic strategies targeting immune dysregulation in the gut.
Prof. Dr. Mihai Danciu
Guest Editor
Manuscript Submission Information
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Keywords
- gastrointestinal immunity
- mucosal barrier function
- immune signaling pathways
- gut microbiota
- inflammatory bowel disease (IBD)
- colorectal cancer
- cytokines and chemokines
- immunopathology
- targeted immunotherapy
- biomarkers of gut inflammation
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